INTRODUCTION: The aim of this study was to evaluate the accuracy and reliability of the Magseed magnetic marker in breast cancer surgery. METHODS: Thirty-nine patients with 41 implanted Magseeds undergoing surgical treatment in 3 surgical oncology departments were included in the retrospective trial to study pilot use of the Magseed magnetic marker in the Czech Republic for localisation of breast tumours or pathological axillary nodes in breast cancer patients. RESULTS: Thirty-four breast cancer and 7 pathological lymph node localisations were performed by Magseed implantation. No placement failures, or perioperative detection failures of Magseeds were observed (0/41, 0.0%), but one case of Magseed migration was present (1/41, 2.4%). All magnetic seeds were successfully retrieved (41/41, 100.0%). Negative margins were achieved in 29 of 34 (85.3%) breast tumour localisations by Magseed. CONCLUSION: Magseed is a reliable marker for breast tumour and pathological axillary node localisation in breast cancer patients. Magseed is comparable to conventional localisation methods in terms of oncosurgical radicality and safety.

Department of Surgery Silesian Hospital in Opava Opava Czechia

Department of Surgery University Hospital Ostrava Ostrava Czechia

Department of Surgical Oncology Faculty of Medicine Masaryk University Brno Czechia

Department of Surgical Oncology Masaryk Memorial Cancer Institute Brno Czechia

Department of Surgical Studies Faculty of Medicine University of Ostrava Ostrava Czechia

Oncogynecology Centre The Institute for the Care of Mother and Child Prague Czechia

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Wyld L, Markopoulos C, Leidenius M, Senkus-Konefka E, editors. Springer International Publishing; 2018. Breast Cancer Management for Surgeons: A Euro¬pean Multidisciplinary Textbook.

Dauway EL, Saunders R, Friedland J. Innovative diagnostics for breast cancer new frontiers for the new millennium using radioactive seed localization. Surgical forum: 85th annual American college of surgeons clinic congress. Chicago, IL: American College of Surgeons. 1999;Vol. 50

Cheang E, Ha R, Thornton CM, Mango VL. Innovations in image-guided preoperative breast lesion localization. Br J Radiol. 2018 May;91((1085)):20170740. PubMed PMC

Hayes MK. Update on preoperative breast localization. Radiol Clin North Am. 2017 May;55((3)):591–603. PubMed

Jeffries DO, Dossett LA, Jorns JM. Localization for breast surgery: the next generation. Arch Pathol Lab Med. 2017 Oct;141((10)):1324–9. PubMed

Harvey JR, Lim Y, Murphy J, Howe M, Morris J, Goyal A, et al. Safety and feasibility of breast lesion localization using magnetic seeds (Magseed): a multi-centre, open-label cohort study. Breast Cancer Res Treat. 2018 Jun;169((3)):531–6. PubMed PMC

Žatecký J, Kubala O, Jelínek P, et al. Magnetic marker localisation in breast cancer surgery. Arch Med Sci. 2020;••• PubMed PMC

National Comprehensive Cancer Network Breast Cancer (Version 3. 2020). https://www.nccn.org/professionals/physician_gls/pdf/breast_blocks.pdf.

Caudle AS, Yang WT, Krishnamurthy S, Mittendorf EA, Black DM, Gilcrease MZ, et al. Improved axillary evaluation following neoadjuvant therapy for patients with node-positive breast cancer using selective evaluation of clipped nodes: implementation of targeted axillary dissection. J Clin Oncol. 2016 Apr;34((10)):1072–8. PubMed PMC

Greenwood HI, Wong JM, Mukhtar RA, Alvarado MD, Price ER. Feasibility of Magnetic Seeds for Preoperative Localization of Axillary Lymph Nodes in Breast Cancer Treatment. AJR Am J Roentgenol. 2019 Oct;213((4)):953–7. PubMed

Hartmann S, Reimer T, Gerber B, Stubert J, Stengel B, Stachs A. Wire localization of clip-marked axillary lymph nodes in breast cancer patients treated with primary systemic therapy. Eur J Surg Oncol. 2018 Sep;44((9)):1307–11. PubMed

Kim EY, Byon WS, Lee KH, Yun JS, Park YL, Park CH, et al. Feasibility of Preoperative Axillary Lymph Node Marking with a Clip in Breast Cancer Patients Before Neoadjuvant Chemotherapy: A Preliminary Study. World J Surg. 2018 Feb;42((2)):582–9. PubMed

Woods RW, Camp MS, Durr NJ, Harvey SC. A Review of Options for Localization of Axillary Lymph Nodes in the Treatment of Invasive Breast Cancer. Acad Radiol. 2019 Jun;26((6)):805–19. PubMed

Khallaf E, Wessam R, Abdoon M. Targeted axillary dissection of carbon-tattooed metastatic lymph nodes in combination with post-neo-adjuvant sentinel lymph node biopsy using 1% methylene blue in breast cancer patients. Breast J. 2020 May;26((5)):1061–3. PubMed

Price ER, Khoury AL, Esserman LJ, Joe BN, Alvarado MD. Initial Clinical Experience With an Inducible Magnetic Seed System for Preoperative Breast Lesion Localization. AJR Am J Roentgenol. 2018 Apr;210((4)):913–7. PubMed

Hersi AF, Eriksson S, Ramos J, Abdsaleh S, Wärnberg F, Karakatsanis A. A combined, totally magnetic technique with a magnetic marker for non-palpable tumour localization and superparamagnetic iron oxide nanoparticles for sentinel lymph node detection in breast cancer surgery. Eur J Surg Oncol. 2019 Apr;45((4)):544–9. PubMed

Pohlodek K, Foltín M, Mečiarová I, Ondriaš F. Simultaneous use of magnetic method in localization of impalpable breast cancer and sentinel lymph nodes detection: initial experience. Nanomedicine (Lond) 2018 Dec;13((24)):3075–81. PubMed

Lamb LR, Bahl M, Specht MC, D'Alessandro HA, Lehman CD. Evaluation of a Nonradioactive Magnetic Marker Wireless Localization Program. AJR Am J Roentgenol. 2018 Oct;211((4)):940–5. PubMed

Thekkinkattil D, Kaushik M, Hoosein MM, Al-Attar M, Pilgrim S, Gvaramadze A, et al. A prospective, single-arm, multicentre clinical evaluation of a new localisation technique using non-radioactive Magseeds for surgery of clinically occult breast lesions. Clin Radiol. 2019 Dec;74((12)):974.e7–11. PubMed

Green M, Vidya R. Techniques Used to Localize Occult Breast Lesions: an Update. Clin Breast Cancer. 2018 Jun;18((3)):e281–3. PubMed

Corsi F, Sorrentino L, Bossi D, Sartani A, Foschi D. Preoperative localization and surgical margins in conservative breast surgery. Int J Surg Oncol. 2013;2013:793819. PubMed PMC

Zacharioudakis K, Down S, Bholah Z, Lee S, Khan T, Maxwell AJ, et al. Is the future magnetic? Magseed localisation for non palpable breast cancer. A multi-centre non randomised control study. Eur J Surg Oncol. 2019 Nov;45((11)):2016–21. PubMed

McGhan LJ, McKeever SC, Pockaj BA, Wasif N, Giurescu ME, Walton HA, et al. Radioactive seed localization for nonpalpable breast lesions: review of 1,000 consecutive procedures at a single institution. Ann Surg Oncol. 2011 Oct;18((11)):3096–101. PubMed

Chacko SM, Marshall HN. Implementation of Preoperative Magnetic Seed Localization for Breast and Axillary Lesions: An Alternative to Wires and Radioactive Seeds. J Radiol Nurs. 2018 Sep;37((3)):154–7.

Lee C, Bhatt A, Felmlee JP, Trester P, Lanners D, Paulsen A, et al. How to Safely Perform Magnetic Resonance Imaging-guided Radioactive Seed Localizations in the Breast. JCIS. Scientific Scholar; 2020 Apr 9;10:19. PubMed PMC

Greenwood HI, Dodelzon K, Katzen JT. Impact of Advancing Technology on Diagnosis and Treatment of Breast Cancer. Surg Clin North Am. 2018 Aug;98((4)):703–24. PubMed

Ideal marker for targeted axillary dissection (IMTAD): a prospective multicentre trial