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Longitudinal Structural Brain Changes in Bipolar Disorder: A Multicenter Neuroimaging Study of 1232 Individuals by the ENIGMA Bipolar Disorder Working Group

Biological psychiatry. 2022 Mar 15 ; 91 (6) : 582-592. [epub] 20210916

Biol Psychiatry
ISSN 1873-2402 | 0006-3223
Source

Language English Country United States Media print-electronic

Document type Journal Article, Multicenter Study, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't

Persistent link https://www.medvik.cz/link/pmid34809987

PubMed 34809987
DOI 10.1016/j.biopsych.2021.09.008
PII: S0006-3223(21)01597-3
Knihovny.cz E-resources

Keywords
Bipolar disorder, ENIGMA, Longitudinal study, Neuroimaging, Neuroprogression, Psychiatry,
MeSH
Bipolar Disorder * pathology MeSH
Adult MeSH
Middle Aged MeSH
Humans MeSH
Magnetic Resonance Imaging MeSH
Mania MeSH
Young Adult MeSH
Brain diagnostic imaging pathology MeSH
Multicenter Studies as Topic MeSH
Neuroimaging MeSH
Cerebral Cortical Thinning MeSH
Check Tag
Adult MeSH
Middle Aged MeSH
Humans MeSH
Young Adult MeSH
Male MeSH
Female MeSH
Publication type
Journal Article MeSH
Multicenter Study MeSH
Research Support, Non-U.S. Gov't MeSH
Research Support, N.I.H., Extramural MeSH

BACKGROUND: Bipolar disorder (BD) is associated with cortical and subcortical structural brain abnormalities. It is unclear whether such alterations progressively change over time, and how this is related to the number of mood episodes. To address this question, we analyzed a large and diverse international sample with longitudinal magnetic resonance imaging (MRI) and clinical data to examine structural brain changes over time in BD. METHODS: Longitudinal structural MRI and clinical data from the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) BD Working Group, including 307 patients with BD and 925 healthy control subjects, were collected from 14 sites worldwide. Male and female participants, aged 40 ± 17 years, underwent MRI at 2 time points. Cortical thickness, surface area, and subcortical volumes were estimated using FreeSurfer. Annualized change rates for each imaging phenotype were compared between patients with BD and healthy control subjects. Within patients, we related brain change rates to the number of mood episodes between time points and tested for effects of demographic and clinical variables. RESULTS: Compared with healthy control subjects, patients with BD showed faster enlargement of ventricular volumes and slower thinning of the fusiform and parahippocampal cortex (0.18

Center for Psychiatric Research Department of Clinical Neuroscience Karolinska Institutet and Stockholm Health Care Services Stockholm County Council Stockholm Sweden; Early Psychosis Interventions and Clinical detection lab Department of Psychosis Studies Institute of Psychiatry Psychology and Neuroscience King's College London London United Kingdom; Centro de Investigación Biomédica en Red de Salud Mental Barcelona Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer Barcelona Spain; Institute for Translational Psychiatry University of Münster Münster Germany

Centre for Neuroimaging and Cognitive Genomics Clinical Neuroimaging Laboratory NCBES Galway Neuroscience Centre College of Medicine Nursing and Health Sciences National University of Ireland Galway Ireland

Centro de Investigación Biomédica en Red de Salud Mental Barcelona Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer Barcelona Spain; Barcelona Bipolar Disorders and Depressive Unit Hospital Clínic Institute of Neurosciences Barcelona Spain; University of Barcelona Barcelona Spain

Clinic for Radiology University of Münster Münster Germany

Department of Clinical Neuroscience Centre for Psychiatric Research Karolinska Institutet Stockholm Sweden; Norwegian Centre for Mental Disorders Research Division of Mental Health and Addiction Oslo University Hospital Oslo Norway; KG Jebsen Centre for Neurodevelopmental Disorders Institute of Clinical Medicine University of Oslo Oslo Norway; Department of Psychiatric Research Diakonhjemmet Hospital Oslo Norway

Department of Clinical Neuroscience Osher Center Karolinska Institutet Stockholm Sweden

Department of Clinical Neuroscience Osher Center Karolinska Institutet Stockholm Sweden; Karolinska University Hospital Department of Neuroradiology Stockholm Sweden

Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden; Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology Sahlgrenska Academy University of Gothenburg Gothenburg Sweden

Department of Neurology Oslo University Hospital Oslo Norway; Department of Psychiatry and Addiction Section for C L Psychiatry and Psychosomatics Oslo University Hospital Oslo Norway

Department of Psychiatry and Psychotherapy Philipps University Marburg Marburg Germany; Center for Mind Brain and Behavior University of Marburg and Justus Liebig University of Giessen Giessen Germany

Department of Psychiatry Dalhousie University Halifax Nova Scotia

Department of Psychiatry Dalhousie University Halifax Nova Scotia; National Institute of Mental Health Klecany Czech Republic