Selective deficits in attentional set-shifting in mice induced by maternal immune activation with poly(I:C)
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
34838932
DOI
10.1016/j.bbr.2021.113678
PII: S0166-4328(21)00566-0
Knihovny.cz E-resources
- Keywords
- Behavioral tests, Cognitive deficit, Immunochallenge, Interneurons, Maternal immune activation, Mouse, Poly(I:C), Prenatal infection, Schizophrenia,
- MeSH
- Behavior, Animal physiology MeSH
- Executive Function physiology MeSH
- Hippocampus cytology MeSH
- Pregnancy Complications, Infectious * chemically induced immunology MeSH
- Interneurons cytology MeSH
- Cognitive Dysfunction etiology pathology physiopathology MeSH
- Disease Models, Animal MeSH
- Mice, Inbred C57BL MeSH
- Mice MeSH
- Poly I-C administration & dosage MeSH
- Attention physiology MeSH
- Stress, Psychological complications pathology physiopathology MeSH
- Schizophrenia etiology immunology pathology physiopathology MeSH
- Pregnancy MeSH
- Prenatal Exposure Delayed Effects chemically induced pathology physiopathology MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Mice MeSH
- Pregnancy MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Poly I-C MeSH
Maternal immune activation has been identified as a significant risk factor for schizophrenia. Using rodent models, past work has demonstrated various behavioral and brain impairments in offspring after immune-activating events. We applied 5 mg/kg of poly(I:C) on gestation day 9 to pregnant mouse dams, whose offspring were then stressed during puberty. We show impairments in attentional set-shifting in a T-maze, and a decreased number of parvalbumin-positive interneurons in the hippocampus as a result of peripubertal stress specifically in females.
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