Maternal immune activation has been identified as a significant risk factor for schizophrenia. Using rodent models, past work has demonstrated various behavioral and brain impairments in offspring after immune-activating events. We applied 5 mg/kg of poly(I:C) on gestation day 9 to pregnant mouse dams, whose offspring were then stressed during puberty. We show impairments in attentional set-shifting in a T-maze, and a decreased number of parvalbumin-positive interneurons in the hippocampus as a result of peripubertal stress specifically in females.

• MeSH
• Behavior, Animal physiology   MeSH
• Executive Function physiology   MeSH
• Hippocampus cytology   MeSH
• Pregnancy Complications, Infectious * chemically induced   immunology   MeSH
• Interneurons cytology   MeSH
• Cognitive Dysfunction etiology   pathology   physiopathology   MeSH
• Disease Models, Animal MeSH
• Mice, Inbred C57BL MeSH
• Poly I-C administration & dosage   MeSH
• Attention physiology   MeSH
• Stress, Psychological complications   pathology   physiopathology   MeSH
• Schizophrenia etiology   immunology   pathology   physiopathology   MeSH
• Pregnancy MeSH
• Prenatal Exposure Delayed Effects chemically induced   pathology   physiopathology   MeSH
• Animals MeSH
• Check Tag
• Male MeSH
• Pregnancy MeSH
• Female MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH

• MeSH
• Polysaccharides, Bacterial administration & dosage   MeSH
• Time Factors MeSH
• Endotoxins administration & dosage   MeSH
• Escherichia coli MeSH
• Interferon Inducers administration & dosage   MeSH
• Injections, Intraperitoneal MeSH
• Interferons blood   MeSH
• Lipopolysaccharides administration & dosage   MeSH
• Mice MeSH
• Poly I-C administration & dosage   MeSH
• Virus Diseases blood   mortality   prevention & control   MeSH
• Encephalomyocarditis virus MeSH
• Animals MeSH
• Check Tag
• Mice MeSH
• Female MeSH
• Animals MeSH