The protein-lipid complex alpha1-oleate, derived from HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells), is identified as a molecular entity with significant therapeutic potential. Structural characterization of the complex and results of a successful placebo-controlled clinical trial are presented.

2nd Faculty of Medicine Charles University Praha Prague Czech Republic

Department of Urology Motol University Hospital Prague Czech Republic

Division of Microbiology Immunology and Glycobiology Department of Laboratory Medicine Faculty of Medicine Lund University Lund Sweden

Singapore Centre for Environmental Life Sciences Engineering Nanyang Technological University Singapore Singapore

Trinity College Dublin Trinity Biomedical Sciences Institute School of Biochemistry and Immunology Dublin Ireland

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