EAU Guidelines on Non-Muscle-invasive Urothelial Carcinoma of the Bladder: Update 2016
Language English Country Switzerland Media print-electronic
Document type Journal Article
PubMed
27324428
DOI
10.1016/j.eururo.2016.05.041
PII: S0302-2838(16)30249-4
Knihovny.cz E-resources
- Keywords
- Bacillus Calmette-Guérin (BCG), Bladder cancer, Cystectomy, Diagnosis, European Association of Urology, Guidelines, Intravesical chemotherapy, Prognosis, Transurethral resection (TUR), Urothelial carcinoma,
- MeSH
- Adjuvants, Immunologic administration & dosage MeSH
- Administration, Intravesical MeSH
- BCG Vaccine administration & dosage MeSH
- Cystectomy * MeSH
- Cystoscopy * MeSH
- Muscle, Smooth pathology MeSH
- Neoplasm Invasiveness MeSH
- Carcinoma in Situ pathology therapy MeSH
- Carcinoma, Transitional Cell pathology therapy MeSH
- Humans MeSH
- Urinary Bladder pathology MeSH
- Urinary Bladder Neoplasms pathology therapy MeSH
- Antineoplastic Agents administration & dosage MeSH
- Practice Guidelines as Topic MeSH
- Societies, Medical MeSH
- Neoplasm Staging MeSH
- Urology MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Geographicals
- Europe MeSH
- Names of Substances
- Adjuvants, Immunologic MeSH
- BCG Vaccine MeSH
- Antineoplastic Agents MeSH
CONTEXT: The European Association of Urology (EAU) panel on Non-muscle-invasive Bladder Cancer (NMIBC) released an updated version of the guidelines on Non-muscle-invasive Bladder Cancer. OBJECTIVE: To present the 2016 EAU guidelines on NMIBC. EVIDENCE ACQUISITION: A broad and comprehensive scoping exercise covering all areas of the NMIBC guidelines published between April 1, 2014, and May 31, 2015, was performed. Databases covered by the search included Medline, Embase, and the Cochrane Libraries. Previous guidelines were updated, and levels of evidence and grades of recommendation were assigned. EVIDENCE SYNTHESIS: Tumours staged as TaT1 or carcinoma in situ (CIS) are grouped as NMIBC. Diagnosis depends on cystoscopy and histologic evaluation of the tissue obtained by transurethral resection of the bladder (TURB) in papillary tumours or by multiple bladder biopsies in CIS. In papillary lesions, a complete TURB is essential for the patient's prognosis. If the initial resection is incomplete, there is no muscle in the specimen, or a high-grade or T1 tumour is detected, a second TURB should be performed within 2-6 wk. The risks of both recurrence and progression may be estimated for individual patients using the European Organisation for Research and Treatment of Cancer (EORTC) scoring system and risk tables. The stratification of patients into low-, intermediate-, and high-risk groups is pivotal to recommending adjuvant treatment. For patients with a low-risk tumour and intermediate-risk patients at a lower risk of recurrence, one immediate instillation of chemotherapy is recommended. Patients with an intermediate-risk tumour should receive 1 yr of full-dose bacillus Calmette-Guérin (BCG) intravesical immunotherapy or instillations of chemotherapy for a maximum of 1 yr. In patients with high-risk tumours, full-dose intravesical BCG for 1-3 yr is indicated. In patients at highest risk of tumour progression, immediate radical cystectomy (RC) should be considered. RC is recommended in BCG-refractory tumours. The long version of the guidelines is available at the EAU Web site (www.uroweb.org/guidelines). CONCLUSIONS: These abridged EAU guidelines present updated information on the diagnosis and treatment of NMIBC for incorporation into clinical practice. PATIENT SUMMARY: The European Association of Urology has released updated guidelines on Non-muscle-invasive Bladder Cancer (NMIBC). Stratification of patients into low-, intermediate-, and high-risk groups is essential for decisions about adjuvant intravesical instillations. Risk tables can be used to estimate risks of recurrence and progression. Radical cystectomy should be considered only in case of failure of instillations or in NMIBC with the highest risk of progression.
Department of Pathology Hôpital La Pitié Salpétrière UPMC Paris France
Department of Urology Caritas St Josef Medical Centre University of Regensburg Regensburg Germany
Department of Urology Fundació Puigvert Universidad Autónoma de Barcelona Barcelona Spain
Department of Urology HELIOS Agnes Karll Krankenhaus Bad Schwartau Germany
Department of Urology Hospital Motol 2nd Faculty of Medicine Charles University Praha Czech Republic
Department of Urology Hospital Universitario Fundación Alcorcón Madrid Spain
Department of Urology Hyvinkää Hospital Hyvinkää Finland
Department of Urology Medical University of Graz Graz Austria
European Association of Urology Guidelines Office Brussels Belgium
Medical University of Vienna Vienna General Hospital Vienna Austria
References provided by Crossref.org
Clinical and molecular response to alpha1-oleate treatment in patients with bladder cancer
Bladder cancer therapy using a conformationally fluid tumoricidal peptide complex
SIU-ICUD on bladder cancer: pathology
