LDL-C augments whereas HDL-C prevents inflammatory innate immune memory
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
34865983
DOI
10.1016/j.molmed.2021.11.003
PII: S1471-4914(21)00300-2
Knihovny.cz E-resources
- Keywords
- atherosclerosis, cholesterol, endotoxemia, inflammation, innate immune memory, liver,
- MeSH
- Cholesterol, HDL * MeSH
- Immunologic Memory * MeSH
- Cholesterol, LDL * MeSH
- Humans MeSH
- Immunity, Innate * MeSH
- Inflammation MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Cholesterol, HDL * MeSH
- Cholesterol, LDL * MeSH
Recent studies emphasize the importance of low-density lipoprotein cholesterol (LDL-C) in altering the hematopoietic cell compartment of bone marrow and of high-density lipoprotein cholesterol (HDL-C) in inhibiting metabolic endotoxemia-induced inflammation. The data suggest that these lipoproteins may exert their inflammatory or anti-inflammatory roles by modulating innate immune memory. Targeting specific LDL-C and HDL-C subfractions could therefore potentially reduce the residual risk in hepatic and cardiometabolic disease.
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