Characteristics of subjective cognitive decline associated with amyloid positivity
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, N.I.H., Extramural
Grant support
U01 AG024904
NIA NIH HHS - United States
CIHR - Canada
PubMed
34877782
PubMed Central
PMC9786747
DOI
10.1002/alz.12512
Knihovny.cz E-resources
- Keywords
- Alzheimer's disease, amyloid, cerebrospinal fluid, positron emission tomography, subjective cognitive decline,
- MeSH
- Amyloid MeSH
- Amyloidogenic Proteins MeSH
- Amyloidosis * MeSH
- Apolipoprotein E4 genetics MeSH
- Biomarkers MeSH
- Cognitive Dysfunction * genetics psychology MeSH
- Humans MeSH
- Brain metabolism MeSH
- Positron-Emission Tomography MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Research Support, N.I.H., Extramural MeSH
- Research Support, U.S. Gov't, Non-P.H.S. MeSH
- Names of Substances
- Amyloid MeSH
- Amyloidogenic Proteins MeSH
- Apolipoprotein E4 MeSH
- Biomarkers MeSH
INTRODUCTION: The evidence for characteristics of persons with subjective cognitive decline (SCD) associated with amyloid positivity is limited. METHODS: In 1640 persons with SCD from 20 Amyloid Biomarker Study cohort, we investigated the associations of SCD-specific characteristics (informant confirmation, domain-specific complaints, concerns, feelings of worse performance) demographics, setting, apolipoprotein E gene (APOE) ε4 carriership, and neuropsychiatric symptoms with amyloid positivity. RESULTS: Between cohorts, amyloid positivity in 70-year-olds varied from 10% to 76%. Only older age, clinical setting, and APOE ε4 carriership showed univariate associations with increased amyloid positivity. After adjusting for these, lower education was also associated with increased amyloid positivity. Only within a research setting, informant-confirmed complaints, memory complaints, attention/concentration complaints, and no depressive symptoms were associated with increased amyloid positivity. Feelings of worse performance were associated with less amyloid positivity at younger ages and more at older ages. DISCUSSION: Next to age, setting, and APOE ε4 carriership, SCD-specific characteristics may facilitate the identification of amyloid-positive individuals.
Carol DAVILA University of Medicine and Pharmacy Bucharest Romania
Centre for Studies on Prevention of Alzheimer's Disease Centre Montreal Quebec Canada
Clinical Memory Research Unit Department of Clinical Sciences Malmö Lund University Lund Sweden
CSIRO Health and Biosecurity Parkville Victoria Australia
Department of Clinical Sciences Malmö Clinical Memory Research Unit Lund University Lund Sweden
Department of Geriatric Psychiatry Psychiatric University Hospital Zürich Switzerland
Department of Molecular Imaging and Therapy Austin Health Melbourne Australia
Department of Neurobiology Care Sciences and Society Karolinska Institutet Stockholm Sweden
Department of Neurodegenerative Diseases and Psychiatry University Hospital Bonn Bonn Germany
Department of Neurology Akershus University Hospital Lorenskog Norway
Department of Psychiatry University of Cologne Cologne Germany
Department of Psychiatry University of Pittsburgh Pittsburgh USA
Functional Neuroimaging Group Department of Radiology University Hospital Bonn Bonn Germany
Helen Wills Neuroscience Institute University of California Berkeley California USA
Institut National de la Sant et de la Recherche M dicale Caen France
Institute of Clinical Medicine Neurology University of Eastern Finland Kuopio Finland
Institute of Clinical Medicine University of Oslo Oslo Norway
International Clinical Research Center St Anne's University Hospital Brno Czech Republic
Kingston The University of Rhode Island Rhode Island USA
Klinik für Psychiatrie und Psychotherapie Charité Universitätsmedizin Berlin CBF Berlin Deutschland
Neurology Department Hospital de Sant Pau Barcelona Spain
Old Age Psychiatry University Hospital of Lausanne Lausanne Switzerland
Vrije Universiteit Brussel Brussels and University of Antwerp Antwerp Belgium
See more in PubMed
Morris JC. Early‐stage and preclinical Alzheimer disease. Alzheimer Dis Assoc Disord. 2005;19:163‐165. PubMed
Vos SJ, Xiong C, Visser PJ, et al. Preclinical Alzheimer's disease and its outcome: a longitudinal cohort study. Lancet Neurol. 2013;12:957‐965. PubMed PMC
Jansen WJ, Ossenkoppele R, Knol DL, et al. Prevalence of cerebral amyloid pathology in persons without dementia: a meta‐analysis. JAMA. 2015;313:1924‐1938. PubMed PMC
Ebenau JL, Timmers T, Wesselman LMP, et al. ATN classification and clinical progression in subjective cognitive decline: the SCIENCe project. Neurology. 2020;95:e46‐e58. PubMed PMC
Mitchell AJ, Beaumont H, Ferguson D, Yadegarfar M, Stubbs B. Risk of dementia and mild cognitive impairment in older people with subjective memory complaints: meta‐analysis. Acta Psychiatr Scand. 2014;130:439‐451. PubMed
Slot RER, Sikkes SAM, Berkhof J, et al. Subjective cognitive decline and rates of incident Alzheimer's disease and non‐Alzheimer's disease dementia. Alzheimers Dement. 2019;15:465‐476. PubMed PMC
Stewart R. Subjective cognitive impairment. Curr Opin Psychiatry. 2012;25:445‐450. PubMed
Amariglio RE, Becker JA, Carmasin J, et al. Subjective cognitive complaints and amyloid burden in cognitively normal older individuals. Neuropsychologia. 2012;50:2880‐2886. PubMed PMC
Perrotin A, Mormino EC, Madison CM, Hayenga AO, Jagust WJ. Subjective cognition and amyloid deposition imaging: a Pittsburgh Compound B positron emission tomography study in normal elderly individuals. Arch Neurol. 2012;69:223‐229. PubMed PMC
Buckley RF, Sikkes S, Villemagne VL, et al. Using subjective cognitive decline to identify high global amyloid in community‐based samples: a cross‐cohort study. Alzheimers Dement (Amst). 2019;11:670‐678. PubMed PMC
Mielke MM, Wiste HJ, Weigand SD, et al. Indicators of amyloid burden in a population‐based study of cognitively normal elderly. Neurology. 2012;79:1570‐1577. PubMed PMC
Chetelat G, Villemagne VL, Bourgeat P, et al. Relationship between atrophy and beta‐amyloid deposition in Alzheimer disease. Ann Neurol. 2010;67:317‐324. PubMed
Jessen F, Amariglio RE, van Boxtel M, et al. A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease. Alzheimers Dement. 2014;10:844‐852. PubMed PMC
Jessen F, Amariglio RE, Buckley RF, et al. The characterisation of subjective cognitive decline. Lancet Neurol. 2020;19:271‐278. PubMed PMC
Risacher SL, Kim S, Nho K, et al. APOE effect on Alzheimer's disease biomarkers in older adults with significant memory concern. Alzheimers Dement. 2015;11:1417‐1429. PubMed PMC
Buckley RF, Mormino EC, Amariglio RE, et al. Sex, amyloid, and APOE epsilon4 and risk of cognitive decline in preclinical Alzheimer's disease: findings from three well‐characterized cohorts. Alzheimers Dement. 2018;14:1193‐1203. PubMed PMC
Jorm AF, Butterworth P, Anstey KJ, et al. Memory complaints in a community sample aged 60‐64 years: associations with cognitive functioning, psychiatric symptoms, medical conditions, APOE genotype, hippocampus and amygdala volumes, and white‐matter hyperintensities. Psychol Med. 2004;34:1495‐1506. PubMed
Perrotin A, La Joie R, de La Sayette V, et al. Subjective cognitive decline in cognitively normal elders from the community or from a memory clinic: differential affective and imaging correlates. Alzheimers Dement. 2017;13:550‐560. PubMed
Slot RER, Verfaillie SCJ, Overbeek JM, et al. Subjective Cognitive Impairment Cohort (SCIENCe): study design and first results. Alzheimers Res Ther. 2018;10:76. PubMed PMC
Miebach L, Wolfsgruber S, Polcher A, et al. Which features of subjective cognitive decline are related to amyloid pathology? Findings from the DELCODE study. Alzheimers Res Ther. 2019;11:66. PubMed PMC
Ossenkoppele R, Jansen WJ, Rabinovici GD, et al. Prevalence of amyloid PET positivity in dementia syndromes: a meta‐analysis. JAMA. 2015;313:1939‐1949. PubMed PMC
Hubbard AE, Ahern J, Fleischer NL, et al. To GEE or not to GEE: comparing population average and mixed models for estimating the associations between neighborhood risk factors and health. Epidemiology. 2010;21:467‐474. PubMed
Jansen WJ, Ossenkoppele R, Tijms BM, et al. Association of cerebral amyloid‐beta aggregation with cognitive functioning in persons without dementia. JAMA Psychiatry. 2018;75:84‐95. PubMed PMC
Evans DA, Hebert LE, Beckett LA, et al. Education and other measures of socioeconomic status and risk of incident Alzheimer disease in a defined population of older persons. Arch Neurol. 1997;54:1399‐1405. PubMed
Stern Y. Cognitive reserve and Alzheimer disease. Alzheimer Dis Assoc Disord. 2006;20:S69‐S74. PubMed
Shokouhi S, Conley AC, Baker SL, et al. The relationship between domain‐specific subjective cognitive decline and Alzheimer's pathology in normal elderly adults. Neurobiol Aging. 2019;81:22‐29. PubMed PMC
Valech N, Mollica MA, Olives J, et al. Informants' perception of subjective cognitive decline helps to discriminate preclinical Alzheimer's disease from normal aging. J Alzheimers Dis. 2015;48(1):S87‐S98. PubMed
Verfaillie SCJ, Timmers T, Slot RER, et al. Amyloid‐beta load is related to worries, but not to severity of cognitive complaints in individuals with subjective cognitive decline: the SCIENCe Project. Front Aging Neurosci. 2019;11:7. PubMed PMC
Rosenberg PB, Mielke MM, Appleby BS, Oh ES, Geda YE, Lyketsos CG. The association of neuropsychiatric symptoms in MCI with incident dementia and Alzheimer disease. Am J Geriatr Psychiatry. 2013;21:685‐695. PubMed PMC
Espenes R, Kirsebom BE, Eriksson C, et al. Amyloid plaques and symptoms of depression links to medical help‐seeking due to subjective cognitive decline. J Alzheimers Dis. 2020;75:879‐890. PubMed PMC
McWhirter L, Ritchie C, Stone J, Carson A. Functional cognitive disorders: a systematic review. Lancet Psychiatry. 2020;7:191‐207. PubMed
Jonker C, Geerlings MI, Schmand B. Are memory complaints predictive for dementia? A review of clinical and population‐based studies. Int J Geriatr Psychiatry. 2000;15:983‐991. PubMed
Rabin LA, Smart CM, Crane PK, et al. Subjective Cognitive decline in older adults: an overview of self‐report measures used across 19 international research studies. J Alzheimers Dis. 2015;48(1):S63‐S86. PubMed PMC
Wolfsgruber S, Kleineidam L, Wagner M, et al. Differential risk of incident Alzheimer's disease dementia in stable versus unstable patterns of subjective cognitive decline. J Alzheimers Dis. 2016;54:1135‐1146. PubMed
