Hematological profile of untreated or ionizing radiation-exposed cyclooxygenase-2-deficient mice
Language English Country Czech Republic Media print-electronic
Document type Journal Article
Grant support
Z99 ES999999
Intramural NIH HHS - United States
PubMed
28406698
PubMed Central
PMC6057777
DOI
10.33549/physiolres.933568
PII: 933568
Knihovny.cz E-resources
- MeSH
- Cyclooxygenase 2 deficiency radiation effects MeSH
- Hematopoiesis physiology radiation effects MeSH
- Radiation, Ionizing * MeSH
- Mice, 129 Strain MeSH
- Mice, Knockout MeSH
- Mice MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Cyclooxygenase 2 MeSH
- Ptgs2 protein, mouse MeSH Browser
We investigated hematopoiesis in untreated and ionizing radiation-exposed cyclooxygenase-2-deficient (COX-2 KO) mice. We performed a complex hematological analysis of 16 parameters in untreated COX-2 KO male mice or COX-2 KO male mice irradiated with the dose of 4 Gy of gamma-rays and their wildtype littermates. At baseline, hematopoiesis was increased in COX-2-deficient mice, but attenuated by irradation in COX-2-deficient mice compared to wildtype. To conclude, the anti-inflammatory action of the COX-2 genetic disruption plays a positive role in hematopoiesis under basal conditions but is detrimental following radiation exposure.
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