• This record comes from PubMed

Hematological profile of untreated or ionizing radiation-exposed cyclooxygenase-2-deficient mice

. 2017 Sep 22 ; 66 (4) : 673-676. [epub] 20170412

Language English Country Czech Republic Media print-electronic

Document type Journal Article

Grant support
Z99 ES999999 Intramural NIH HHS - United States

We investigated hematopoiesis in untreated and ionizing radiation-exposed cyclooxygenase-2-deficient (COX-2 KO) mice. We performed a complex hematological analysis of 16 parameters in untreated COX-2 KO male mice or COX-2 KO male mice irradiated with the dose of 4 Gy of gamma-rays and their wildtype littermates. At baseline, hematopoiesis was increased in COX-2-deficient mice, but attenuated by irradation in COX-2-deficient mice compared to wildtype. To conclude, the anti-inflammatory action of the COX-2 genetic disruption plays a positive role in hematopoiesis under basal conditions but is detrimental following radiation exposure.

See more in PubMed

Carabba M, Paresce E, Angelini M, Galanti A, Marini MG, Cigarini P. A comparison of the local tolerability, safety and efficacy of meloxicam and piroxicam suppositories in patients with osteoarthritis: A single blind, randomized, multicentre study. Curr. Med. Res. Opin. 1995;13:343–355. PubMed

Casey-Sawicki K, Zhang M, Kim S, Zhang A, Zhang SB, Zhang ZH, Singh R, Yang SM, Swarts S, Vidyasagar S, Zhang LR, Zhang AG, Okunieff P. A basic fibroblast growth factor analog for protection and mitigation against acute radiation syndromes. Health Phys. 2014;106:704–712. PubMed

Hofer M, Pospíšil M, Dušek L, Hoferová Z, Komůrková D. Hematopoiesis in 5-fluorouracil-treated adenosine A3 receptor knock-out mice. Physiol. Res. 2015;64:255–262. PubMed

Hofer M, Pospíšil M, Dušek L, Hoferová Z, Weiterová L. A single dose of an inhibitor of cyclooxygenase 2, meloxicam, administered shortly after irradiation, increases survival of lethally irradiated mice. Radiat. Res. 2011;176:269–272. PubMed

Hofer M, Pospíšil M, Holá J, Vacek A, Štreitová D, Znojil V. Inhibition of cyclooxygenase 2 in mice increases production of G-CSF and induces radioprotection. Radiat. Res. 2008a;170:566–571. PubMed

Hofer M, Pospíšil M, Znojil V, Holá J, Vacek A, Štreitová D. Meloxicam, an inhibitor of cyclooxygenase-2, increases the level of serum G-CSF and might be usable as an auxiliary means in G-CSF therapy. Physiol. Res. 2008b;57:307–310. PubMed

Hofer M, Pospíšil M, Znojil V, Holá J, Vacek A, Weiterová L, Štreitová D, Kozubík A. Meloxicam, a cyclooxygenase-2 inhibitor, supports hematopoietic recovery in gamma-irradiated mice. Radiat. Res. 2006;166:556–560. PubMed

Morham SG, Langenbach R, Loftin CD, Tiano HF, Vouloumanos N, Jennette JC, Mahler JF, Kluckman KD, Ledford A, Lee CA, Smithies O. Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse. Cell. 1995;83:473–482. PubMed

Patrignani P, Patrono C. Cyclooxygenase inhibitors: From pharmacology to clinical read-outs. Biochim. Biophys. Acta. 2015;1851:422–432. PubMed

Schaue D, Micewicz ED, Ratikan JA, Xie MW, Cheng GH, Mcbride WH. Radiation and inflammation. Semin. Radiat. Oncol. 2015;25:4–10. PubMed PMC

Find record

Citation metrics

Loading data ...

Archiving options

Loading data ...