Toxicity to bronchial cells and endocrine disruptive potentials of indoor air and dust extracts and their association with multiple chemical classes
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
34879546
DOI
10.1016/j.jhazmat.2021.127306
PII: S0304-3894(21)02274-3
Knihovny.cz E-zdroje
- Klíčová slova
- Bioassay, Dust, Endocrine disruption, Indoor air, Mixture,
- MeSH
- látky znečišťující životní prostředí * MeSH
- lidé MeSH
- polycyklické aromatické uhlovodíky * analýza MeSH
- prach analýza MeSH
- znečištění vzduchu ve vnitřním prostředí * analýza MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- látky znečišťující životní prostředí * MeSH
- polycyklické aromatické uhlovodíky * MeSH
- prach MeSH
Pollution of indoor environment, where people spend much of their time, comprises complex mixtures of compounds with vastly understudied hazard potential. This study examined several important specific toxic effects and pollutant levels (177 compounds) of indoor samples (air gas phase, PM10 and dust) from different microenvironments after two extractions with focus on their gas/particle/dust distribution and polarity. The endocrine disruptive (ED) potential was assessed by human cell-based in vitro bioassays addressing anti-/estrogenicity, anti-/androgenicity, aryl hydrocarbon, thyroid and peroxisome proliferator-activated receptor-mediated activities. Potential toxicity to respiratory tract tissue was assessed using human bronchial cell line. The toxicological analyses pointed out the relevance of both inhalation and ingestion exposure, with significant effects detected after exposure to extracts from all three studied matrices with distinct gas/particle distribution patterns. Chemical analyses document the high complexity of indoor pollutant mixtures with greatest levels of phthalates, their emerging alternatives, and PAHs in dust. Despite the detection of up to 108 chemicals, effects were explained only to low extent. This emphasizes data gaps regarding ED potencies of many detected abundant indoor contaminants, but also potential presence of other unidentified ED compounds. The omnipresent ED potentials in indoor environment rise concern regarding associated human health risk.
RECETOX Faculty of Science Masaryk University Kamenice 753 5 pavilion A29 625 00 Brno Czech Republic
UFZ Helmholtz Centre for Environmental Research UFZ Cell Toxicology 04318 Leipzig Germany
Citace poskytuje Crossref.org
