Early life stages are vulnerable to environmental hazards and present important windows of opportunity for lifelong disease prevention. This makes early life a relevant starting point for exposome studies. The Advancing Tools for Human Early Lifecourse Exposome Research and Translation (ATHLETE) project aims to develop a toolbox of exposome tools and a Europe-wide exposome cohort that will be used to systematically quantify the effects of a wide range of community- and individual-level environmental risk factors on mental, cardiometabolic, and respiratory health outcomes and associated biological pathways, longitudinally from early pregnancy through to adolescence. Exposome tool and data development include as follows: (1) a findable, accessible, interoperable, reusable (FAIR) data infrastructure for early life exposome cohort data, including 16 prospective birth cohorts in 11 European countries; (2) targeted and nontargeted approaches to measure a wide range of environmental exposures (urban, chemical, physical, behavioral, social); (3) advanced statistical and toxicological strategies to analyze complex multidimensional exposome data; (4) estimation of associations between the exposome and early organ development, health trajectories, and biological (metagenomic, metabolomic, epigenetic, aging, and stress) pathways; (5) intervention strategies to improve early life urban and chemical exposomes, co-produced with local communities; and (6) child health impacts and associated costs related to the exposome. Data, tools, and results will be assembled in an openly accessible toolbox, which will provide great opportunities for researchers, policymakers, and other stakeholders, beyond the duration of the project. ATHLETE's results will help to better understand and prevent health damage from environmental exposures and their mixtures from the earliest parts of the life course onward.

BCNatal Barcelona Center for Maternal Fetal and Neonatal Medicine Hospital Sant Joan de Déu Barcelona Spain

Bettair Cities SL Barcelona Spain

Biodonostia Research Health Institute Donostia San Sebastian Spain

Bradford Institute for Health Research Bradford Teaching Hospitals NHS Foundation Trust Bradford United Kingdom

Brunel University London College of Health Medicine and Life Sciences Uxbridge United Kingdom

Cancer Epidemiology Unit Department of Medical Sciences University of Turin Turin Italy

Centre for Environmental Sciences Hasselt University Hasselt Belgium

Centre for Health and Environment Leuven University Leuven Belgium

CHU de Rennes University Rennes Inserm EHESP Irset UMR_S 1085 Rennes France

Department of Biosciences Nottingham Trent University Nottingham United Kingdom

Department of Child and Adolescence Psychiatry Erasmus MC University Medical Center Rotterdam The Netherlands

Department of Environmental Health Norwegian Institute of Public Health Oslo Norway

Department of Environmental Sciences Vytautas Magnus University Kaunas Lithuania

Department of Pediatrics Erasmus University Medical Center Rotterdam The Netherlands

Department of Preventive Medicine Keck School of Medicine University of Southern California Los Angeles California

Department of Public Health Policy and Systems University of Liverpool Liverpool United Kingdom

Department of Public Health University of Copenhagen Copenhagen Denmark

Department of Social Medicine School of Medicine University of Crete Heraklion Crete Greece

Department of Surgery and Cancer and Department of Metabolism Digestion and Reproduction Imperial College London London United Kingdom

Epidemiology and Environmental Health Joint Research Unit FISABIO Universitat Jaume 1 Universitat de València València Spain

Faculty of Nursing and Chiropody Universitat de València Valencia Spain

French Agency for Food Environmental and Occupational Health and Safety Risk Assessment Department Maisons Alfort France

Health and Environment Alliance Brussels Belgium

Institut de Recerca Sant Joan de Déu Barcelona Spain

ISGlobal Barcelona Spain

Maternal and Child Health and Development Network 2 Madrid Spain

National Institute for Public Health and the Environment Bilthoven The Netherlands

Population Health Sciences Institute Newcastle University Newcastle United Kingdom

RECETOX Centre Faculty of Science Masaryk University Brno Czech Republic

Spanish Consortium for Research on Epidemiology and Public Health Madrid Spain

The Generation R Study Group Erasmus University Medical Center Rotterdam The Netherlands

Universitat Pompeu Fabra Barcelona Spain

University Grenoble Alpes CNRS INRAE Grenoble INP GAEL Grenoble France

University Grenoble Alpes Inserm CNRS IAB Joint Research Center Team of Environmental Epidemiology Applied to Development and Respiratory Health Grenoble France

University of Basque Country UPV EHU Basque Country Bilbao Spain

University of Groningen University Medical Center Groningen Department of Genetics Groningen The Netherlands

University of Groningen University Medical Center Groningen Genomics Coordination Center Groningen The Netherlands

University Paris Saclay CNRS CentraleSupélec Laboratoire des Signaux et Systèmes Gif sur Yvette France

University Rennes Inserm EHESP Irset UMR_S 1085 Rennes France

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