Suspect and non-targeted screening of chemicals of emerging concern for human biomonitoring, environmental health studies and support to risk assessment: From promises to challenges and harmonisation issues
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
32361063
DOI
10.1016/j.envint.2020.105545
PII: S0160-4120(19)33831-0
Knihovny.cz E-zdroje
- Klíčová slova
- Biomonitoring, Chemical of emerging concern, High resolution mass spectrometry, Metabolites, Non-targeted screening, Suspect screening,
- MeSH
- biologický monitoring * MeSH
- chromatografie kapalinová MeSH
- environmentální zdraví MeSH
- látky znečišťující životní prostředí * analýza toxicita MeSH
- lidé MeSH
- monitorování životního prostředí MeSH
- vystavení vlivu životního prostředí analýza MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- látky znečišťující životní prostředí * MeSH
Large-scale suspect and non-targeted screening approaches based on high-resolution mass spectrometry (HRMS) are today available for chemical profiling and holistic characterisation of biological samples. These advanced techniques allow the simultaneous detection of a large number of chemical features, including markers of human chemical exposure. Such markers are of interest for biomonitoring, environmental health studies and support to risk assessment. Furthermore, these screening approaches have the promising capability to detect chemicals of emerging concern (CECs), document the extent of human chemical exposure, generate new research hypotheses and provide early warning support to policy. Whilst of growing importance in the environment and food safety areas, respectively, CECs remain poorly addressed in the field of human biomonitoring. This shortfall is due to several scientific and methodological reasons, including a global lack of harmonisation. In this context, the main aim of this paper is to present an overview of the basic principles, promises and challenges of suspect and non-targeted screening approaches applied to human samples as this specific field introduce major specificities compared to other fields. Focused on liquid chromatography coupled to HRMS-based data acquisition methods, this overview addresses all steps of these new analytical workflows. Beyond this general picture, the main activities carried out on this topic within the particular framework of the European Human Biomonitoring initiative (project HBM4EU, 2017-2021) are described, with an emphasis on harmonisation measures.
HERACLES Research Center on the Exposome and Health Aristotle University of Thessaloniki Greece
Institute for Risk Assessment Sciences Utrecht University Utrecht the Netherlands
Institute of Legal Medicine and Core Facility Metabolomics Medical University of Innsbruck Austria
Oniris INRAE LABERCA Nantes France
RECETOX Centre Masaryk University Brno Czech Republic
Toxicological Center University of Antwerp Belgium
UFZ Helmholtz Centre for Environmental Research Leipzig Germany
Vrije Universiteit Department Environment and Health Amsterdam the Netherlands
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