BACKGROUND: The NORMAN Association (https://www.norman-network.com/) initiated the NORMAN Suspect List Exchange (NORMAN-SLE; https://www.norman-network.com/nds/SLE/) in 2015, following the NORMAN collaborative trial on non-target screening of environmental water samples by mass spectrometry. Since then, this exchange of information on chemicals that are expected to occur in the environment, along with the accompanying expert knowledge and references, has become a valuable knowledge base for "suspect screening" lists. The NORMAN-SLE now serves as a FAIR (Findable, Accessible, Interoperable, Reusable) chemical information resource worldwide. RESULTS: The NORMAN-SLE contains 99 separate suspect list collections (as of May 2022) from over 70 contributors around the world, totalling over 100,000 unique substances. The substance classes include per- and polyfluoroalkyl substances (PFAS), pharmaceuticals, pesticides, natural toxins, high production volume substances covered under the European REACH regulation (EC: 1272/2008), priority contaminants of emerging concern (CECs) and regulatory lists from NORMAN partners. Several lists focus on transformation products (TPs) and complex features detected in the environment with various levels of provenance and structural information. Each list is available for separate download. The merged, curated collection is also available as the NORMAN Substance Database (NORMAN SusDat). Both the NORMAN-SLE and NORMAN SusDat are integrated within the NORMAN Database System (NDS). The individual NORMAN-SLE lists receive digital object identifiers (DOIs) and traceable versioning via a Zenodo community (https://zenodo.org/communities/norman-sle), with a total of > 40,000 unique views, > 50,000 unique downloads and 40 citations (May 2022). NORMAN-SLE content is progressively integrated into large open chemical databases such as PubChem (https://pubchem.ncbi.nlm.nih.gov/) and the US EPA's CompTox Chemicals Dashboard (https://comptox.epa.gov/dashboard/), enabling further access to these lists, along with the additional functionality and calculated properties these resources offer. PubChem has also integrated significant annotation content from the NORMAN-SLE, including a classification browser (https://pubchem.ncbi.nlm.nih.gov/classification/#hid=101). CONCLUSIONS: The NORMAN-SLE offers a specialized service for hosting suspect screening lists of relevance for the environmental community in an open, FAIR manner that allows integration with other major chemical resources. These efforts foster the exchange of information between scientists and regulators, supporting the paradigm shift to the "one substance, one assessment" approach. New submissions are welcome via the contacts provided on the NORMAN-SLE website (https://www.norman-network.com/nds/SLE/). SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12302-022-00680-6.

Agilent Technologies Inc 5301 Stevens Creek Blvd Santa Clara CA 95051 USA

Agriculture and Agri Food Canada Agriculture et Agroalimentaire Canada 1391 Sandford Street London ON N5V 4T3 Canada

Analytisches Forschungsinstitut Für Non Target Screening GmbH Am Mittleren Moos 48 86167 Augsburg Germany

Bavarian Environment Agency 86179 Augsburg Germany

Biosfer Teslab Reus Spain

Chemical Contamination of Marine Ecosystems Rue de l'Ile d'Yeu BP 21105 44311 Cedex 3 Nantes France

Computational Chemistry and Cheminformatics Branch United States Environmental Protection Agency 109 T W Alexander Drive Research Triangle Park NC 27711 USA

Corteva Agriscience Indianapolis IN USA

Department Environment and Health Amsterdam Institute for Life and Environment Vrije Universiteit Amsterdam The Netherlands

Department of Bioinformatics BiGCaT NUTRIM Maastricht University Maastricht The Netherlands

Department of Chemistry Center for Innovative Technology Vanderbilt Ingram Cancer Center Vanderbilt Institute of Chemical Biology Vanderbilt Institute for Integrative Biosystems Research and Education Vanderbilt University Nashville TN 37235 USA

Department of Chemistry Chemical Biological Centre Umeå University Linnaeus Väg 6 901 87 Umeå Sweden

Department of Chemistry Norwegian University of Science and Technology 7491 Trondheim Norway

Eawag Swiss Federal Institute for Aquatic Science and Technology Überlandstrasse 133 8600 Dübendorf Switzerland

Environment Agency Horizon House Deanery Road Bristol BS1 5AH UK

Environmental and Public Health Analytical Chemistry Research Institute for Pesticides and Water University Jaume 1 Castelló Spain

Environmental Institute Okružná 784 42 972 41 Koš Slovak Republic

Faculty of Chemical and Food Technology Institute of Information Engineering Automation and Mathematics Slovak University of Technology in Bratislava Radlinského 9 812 37 Bratislava Slovak Republic

Food Packaging Forum Foundation Staffelstrasse 10 8045 Zurich Switzerland

Fraunhofer Institute for Molecular Biology and Applied Ecology Schmallenberg Germany

German Environment Agency Wörlitzer Platz 1 Dessau Roßlau Germany

Hope College Holland MI 49422 USA

INERIS National Institute for Environment and Industrial Risks Verneuil en Halatte France

Institute for Biodiversity and Ecosystem Dynamics University of Amsterdam Amsterdam The Netherlands

Institute for Risk Assessment Sciences Utrecht University Utrecht The Netherlands

Institute of Biogeochemistry and Pollutant Dynamics ETH Zurich 8092 Zurich Switzerland

Institute of Ecology Evolution and Diversity Goethe University Frankfurt Am Main Germany

Institute of Environmental Assessment and Water Research Severo Ochoa Excellence Center Barcelona Spain

Institute of Food Safety and Health College of Public Health National Taiwan University 17 Xuzhou Rd Zhongzheng Dist Taipei Taiwan

Institute of Health Research Pere Virgili Tarragona Spain

Institute of Legal Medicine and Core Facility Metabolomics Medical University of Innsbruck Muellerstrasse 44 Innsbruck Austria

Laboratory for Operation Control and Research Zweckverband Landeswasserversorgung Am Spitzigen Berg 1 89129 Langenau Germany

Laboratory of Analytical Chemistry Department of Chemistry National and Kapodistrian University of Athens Panepistimiopolis Zografou 15771 Athens Greece

Leidos Research Triangle Park NC USA

Luxembourg Centre for Systems Biomedicine University of Luxembourg 6 Avenue du Swing 4367 Belvaux Luxembourg

Mass Spec Interpretation Services 3612 Hemlock Park Drive Kingsport TN 37663 USA

National Center for Biotechnology Information National Library of Medicine National Institutes of Health 8600 Rockville Pike Bethesda MD 20894 USA

NILU Norwegian Institute for Air Research Kjeller Norway

Norwegian Geotechnical Institute Ullevål Stadion P O Box 3930 0806 Oslo Norway

Nutrition and Metabolism Branch International Agency for Research On Cancer 150 Cours Albert Thomas 69372 Lyon Cedex 08 France

Oniris INRAE LABERCA 44307 Nantes France

Queensland Alliance for Environmental Health Sciences The University of Queensland Woolloongabba QLD 4102 Australia

RECETOX Faculty of Science Masaryk University Kotlářská 2 Brno Czech Republic

Science for Life Laboratory Department of Environmental Science Stockholm University 10691 Stockholm Sweden

Section for Environmental Chemistry and Physics Plant and Environmental Sciences University of Copenhagen Thorvaldsensvej 40 1871 Frederiksberg C Denmark

State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco Environmental Sciences Chinese Academy of Sciences No 18 Shuangqing Road Haidian District Beijing 100086 China

Swedish Chemicals Agency P O Box 2 172 13 Sundbyberg Sweden

Swedish University of Agricultural Sciences Uppsala Sweden

Technologies for Water Management and Treatment Research Group Department of Civil Engineering University of Granada Campus de Fuentenueva S N 18071 Granada Spain

Technology and Society Laboratory Empa Swiss Federal Laboratories for Materials Science and Technology Lerchenfeldstrasse 5 9014 St Gallen Switzerland

Thermo Fisher Scientific Dornierstrasse 4 82110 Germering Germany

Toxicological Centre University of Antwerp Antwerp Belgium

UFZ Helmholtz Centre for Environmental Research Leipzig Germany

University of Alberta Edmonton AB T6G 2G3 Canada

University of California Berkeley CA USA

University Rovira i Virgili Tarragona Spain

Van't Hoff Institute for Molecular Sciences University of Amsterdam P O Box 94157 Amsterdam 1090 GD The Netherlands

Water Research Institute Nábr Arm Gen L Svobodu 5 81249 Bratislava Slovak Republic

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