Non-target analysis (NTA) employing high-resolution mass spectrometry is a commonly applied approach for the detection of novel chemicals of emerging concern in complex environmental samples. NTA typically results in large and information-rich datasets that require computer aided (ideally automated) strategies for their processing and interpretation. Such strategies do however raise the challenge of reproducibility between and within different processing workflows. An effective strategy to mitigate such problems is the implementation of inter-laboratory studies (ILS) with the aim to evaluate different workflows and agree on harmonized/standardized quality control procedures. Here we present the data generated during such an ILS. This study was organized through the Norman Network and included 21 participants from 11 countries. A set of samples based on the passive sampling of drinking water pre and post treatment was shipped to all the participating laboratories for analysis, using one pre-defined method and one locally (i.e. in-house) developed method. The data generated represents a valuable resource (i.e. benchmark) for future developments of algorithms and workflows for NTA experiments.

Aarhus University Department of Environmental Science Environmental Metabolomics Lab Frederiksborgvej 399 4000 Roskilde Denmark

BRGM F 45060 Orleans France

Colorado State University Soil and Crop Sciences Department Plant Sciences C117 Fort Collins CO 80523 United States

Consiglio Nazionale delle Ricerche Istituto di Ricerca Sulle Acque Via De Blasio 5 70132 Bari Italy

Department of Aquatic Sciences and Assessment Swedish University of Agricultural Sciences SE 75007 Uppsala Sweden

Department of Chemistry University of Natural Resources and Life Sciences BOKU Vienna Muthgasse 18 1190 Vienna Austria

Department of Environment and Health Faculty of Science Amsterdam Institute of Molecular and Life Sciences Vrije Universiteit Amsterdam De Boelelaan 1085 1081 Amsterdam HV The Netherlands

Eawag Swiss Federal Institute of Aquatic Science and Technology 8600 Duebendorf Switzerland

Environmental and Public Health Analytical Chemistry Research Institute for Pesticides and Water University Jaume 1 Avda Vincent Sos Baynat s n 12071 Castelló de la Plana Castellón Spain

Eurolab Srl Via Monsignore Rodolfi 22 IT 36022 Cassola 6 Italy

Flemish Institute for Technological Research Unit Separation and Conversion Technology Boeretang 200 2400 Mol Belgium

INRAE UR RiverLy F 69625 Villeurbanne France

Institut Català de Recerca de l'Aigua Catalan Institute for Water Research Edifici H2O Parc Científic i Tecnològic Universitat de Girona Carrer Emili Grahit 101 E 17003 Girona Spain

Instituto di Ricerca Sulle Acque Consiglio Nazionale delle Ricerche Via Mulino 19 IT 20861 Brugherio MB Italy

Man Technology Environment Research Centre School of Science and Technology Örebro University Fakultetsgatan 1 701 82 Örebro Sweden

Masaryk University Faculty of Science RECETOX Kamenice 753 5 625 00 Brno Czech Republic

Ministry of Infrastructure and Water Management Rijkswaterstaat Zuiderwagenplein 2 8224 Lelystad AD Netherlands

National and Kapodistrian University of Athens Athens Greece

Norwegian Institute for Water Research Gaustadalléen 21 0349 Oslo Norway

OSU EFLUVE Univ Paris Est Creteil CNRS F 94010 Creteil France

Plentzia Marine Station Department of Analytical Chemistry University of the Basque Country Areatza Pasealekua 48620 Plentzia Basque Country Spain

Queensland Alliance for Environmental Health Sciences The University of Queensland 202 Cornwall Street QLD 4102 Woolloongabba Australia

Univ Lyon CNRS Université Claude Bernard Lyon 1 Institut des Sciences Analytiques UMR 5280 5 rue de la Doua F 69100 Villeurbanne France

Univ Paris Est Creteil Ecole des Ponts LEESU F 94010 Creteil France

University of South Bohemia in České Budějovice Faculty of Fisheries and Protection of Waters South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses Zátiší 728 2 CZ 389 25 Vodňany Czech Republic

Van 't Hoff Institute for Molecular Sciences University of Amsterdam Science Park 904 1098 XH Amsterdam The Netherlands

Vitens N 5 Oude Veerweg 1 Zwolle 8001 BE The Netherlands

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The NORMAN Suspect List Exchange (NORMAN-SLE): facilitating European and worldwide collaboration on suspect screening in high resolution mass spectrometry