The development of the exposome concept has been one of the hallmarks of environmental and health research for the last decade. The exposome encompasses the life course environmental exposures including lifestyle factors from the prenatal period onwards. It has inspired many research programs and is expected to influence environmental and health research, practices, and policies. Yet, the links bridging toxicology and the exposome concept have not been well developed. In this review, we describe how the exposome framework can interface with and influence the field of toxicology, as well as how the field of toxicology can help advance the exposome field by providing the needed mechanistic understanding of the exposome impacts on health. Indeed, exposome-informed toxicology is expected to emphasize several orientations including (1) developing approaches integrating multiple stressors, in particular chemical mixtures, as well as the interaction of chemicals with other stressors, (2) using mechanistic frameworks such as the adverse outcome pathways to link the different stressors with toxicity outcomes, (3) characterizing the mechanistic basis of long-term effects by distinguishing different patterns of exposures and further exploring the environment-DNA interface through genetic and epigenetic studies, and (4) improving the links between environmental and human health, in particular through a stronger connection between alterations in our ecosystems and human toxicology. The exposome concept provides the linkage between the complex environment and contemporary mechanistic toxicology. What toxicology can bring to exposome characterization is a needed framework for mechanistic understanding and regulatory outcomes in risk assessment.

Center for Interdisciplinary Research and Innovation HERACLES Research Center on the Exposome and Health Aristotle University of Thessaloniki Thessaloniki 57001 Greece

Department of Environmental Health Sciences Mailman School of Public Health Columbia University New York New York USA

Enve 10 Thessaloniki 55133 Greece

Faculty of Sports Studies Masaryk University Brno 62500 Czech Republic

Inserm UMR S 1124 Université de Paris T3S Paris F 75006 France

RECETOX Faculty of Science Masaryk University Brno 60200 Czech Republic

Service de Biochimie métabolomique et protéomique Hôpital Necker enfants malades AP HP Paris France

Zobrazit více v PubMed

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Adopting Mechanistic Molecular Biology Approaches in Exposome Research for Causal Understanding

Application of AOPs to assist regulatory assessment of chemical risks - Case studies, needs and recommendations

Merging the exposome into an integrated framework for "omics" sciences