Institute of Molecular Genetics of the Czech Academy of Sciences Prague Czech Republic

University Hospital Münster Münster Germany

Zobrazit více v PubMed

Farias Amorim C, Novais FO, Nguyen BT, Nascimento MT, Lago J, Lago AS, et al. Localized skin inflammation during cutaneous leishmaniasis drives a chronic, systemic IFN-gamma signature. PLoS Negl Trop Dis. 2021;15(4):e0009321. doi: 10.1371/journal.pntd.0009321 ; PubMed Central PMCID: PMC8043375. PubMed DOI PMC

Meunier E, Broz P. Interferon-inducible GTPases in cell autonomous and innate immunity. Cell Microbiol. 2016;18(2):168–80. doi: 10.1111/cmi.12546 . PubMed DOI

Rafeld HL, Kolanus W, van Driel IR, Hartland EL. Interferon-induced GTPases orchestrate host cell-autonomous defence against bacterial pathogens. Biochem Soc Trans. 2021;49(3):1287–97. doi: 10.1042/BST20200900 ; PubMed Central PMCID: PMC8286824. PubMed DOI PMC

Tretina K, Park ES, Maminska A, MacMicking JD. Interferon-induced guanylate-binding proteins: Guardians of host defense in health and disease. J Exp Med. 2019;216(3):482–500. doi: 10.1084/jem.20182031 ; PubMed Central PMCID: PMC6400534. PubMed DOI PMC

Man SM, Place DE, Kuriakose T, Kanneganti TD. Interferon-inducible guanylate-binding proteins at the interface of cell-autonomous immunity and inflammasome activation. J Leukoc Biol. 2017;101(1):143–50. doi: 10.1189/jlb.4MR0516-223R ; PubMed Central PMCID: PMC6608036. PubMed DOI PMC

Krayem I, Lipoldova M. Role of host genetics and cytokines in PubMed DOI

MacMicking JD. Interferon-inducible effector mechanisms in cell-autonomous immunity. Nat Rev Immunol. 2012;12(5):367–82. doi: 10.1038/nri3210 ; PubMed Central PMCID: PMC4150610. PubMed DOI PMC

Bogdan C. Macrophages as host, effector and immunoregulatory cells in leishmaniasis: Impact of tissue micro-environment and metabolism. Cytokine X. 2020;2(4):100041. doi: 10.1016/j.cytox.2020.100041 ; PubMed Central PMCID: PMC7885870. PubMed DOI PMC

Canonne-Hergaux F, Gruenheid S, Govoni G, Gros P. The Nramp1 protein and its role in resistance to infection and macrophage function. Proc Assoc Am Physicians. 1999;111(4):283–9. doi: 10.1046/j.1525-1381.1999.99236.x . PubMed DOI

Frank B, Marcu A, de Oliveira Almeida Petersen AL, Weber H, Stigloher C, Mottram JC, et al. Autophagic digestion of PubMed DOI PMC

Haldar AK, Nigam U, Yamamoto M, Coers J, Goyal N. Guanylate binding proteins restrict PubMed DOI PMC

Jayakumar A, Donovan MJ, Tripathi V, Ramalho-Ortigao M, McDowell MA. PubMed DOI PMC

Novais FO, Carvalho LP, Passos S, Roos DS, Carvalho EM, Scott P, et al. Genomic profiling of human PubMed DOI PMC

Sohrabi Y, Volkova V, Kobets T, Havelkova H, Krayem I, Slapnickova M, et al. Genetic regulation of guanylate-binding proteins 2b and 5 during leishmaniasis in mice. Front Immunol. 2018;9:130. doi: 10.3389/fimmu.2018.00130 ; PubMed Central PMCID: PMC5808352. PubMed DOI PMC

Harrington V, Gurung P. Reconciling protective and pathogenic roles of the NLRP3 inflammasome in leishmaniasis. Immunol Rev. 2020;297(1):53–66. doi: 10.1111/imr.12886 ; PubMed Central PMCID: PMC7643606. PubMed DOI PMC

Non-additive strong gene interactions cause striking differences in organ pathology and cytokine response in Leishmaniasis

Functionally distinct regions of the locus Leishmania major response 15 control IgE or IFNγ level in addition to skin lesions