Complex sympathetic regulation in adolescent mitral valve prolapse
Language English Country Czech Republic Media print
Document type Journal Article
PubMed
35099250
PubMed Central
PMC8884399
DOI
10.33549/physiolres.934830
PII: 934830
Knihovny.cz E-resources
- MeSH
- Ventricular Function, Left MeSH
- Galvanic Skin Response MeSH
- Blood Pressure MeSH
- Humans MeSH
- Mitral Valve Insufficiency diagnosis physiopathology MeSH
- Adolescent MeSH
- Prognosis MeSH
- Mitral Valve Prolapse diagnosis physiopathology MeSH
- Heart diagnostic imaging innervation MeSH
- Heart Rate MeSH
- Case-Control Studies MeSH
- Sympathetic Nervous System physiopathology MeSH
- Age Factors MeSH
- Check Tag
- Humans MeSH
- Adolescent MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
Mitral valve prolapse (MVP) belongs to cardiac disorders characterized by impaired closure of mitral leaflets. We studied adolescent group of patients with MVP suffering from symptomatology that cannot be explained by mitral regurgitation alone. Several studies suggested that symptoms can be explained by autonomic, in particular sympathetic-linked dysfunction. Thus, we assessed non-invasive sympathetic indices of blood pressure and heart rate variability and electrodermal activity (EDA). Fifty-three adolescents with MVP (age: 15.1+/-0.4 years) and 43 healthy age- and gender-matched adolescents (age: 14.9+/-0.4 years) were examined. Blood pressure, heart rate and EDA were continuously recorded during 6-min rest. Evaluated parameters were: low frequency band of systolic blood pressure variability, systolic, diastolic and mean blood pressure, mean RR interval, cardiac sympathetic indices: symbolic dynamics (0V%), left ventricular ejection time (LVET), pre-ejection period (PEP), and EDA. Our findings revealed significantly higher systolic, diastolic, and mean blood pressure values, shortened mean RR interval, increased 0V%, and shortened LVET in MVP patients vs. controls (p=0.028, p<0.001, p=0.002, p<0.001, p=0.050, p<0.001; respectively). Our study revealed enhanced cardiovascular sympathetic regulation in adolescent MVP patients. We suggest that evaluation of non-invasive sympathetic parameters could represent potential biomarkers for early diagnosis of cardiovascular complications associated with MVP already at adolescent age.
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