These Special Issue IJMS were dedicated to the major complications responsible for maternal and perinatal morbidity and mortality, such as gestational hypertension (GH), preeclampsia (PE), fetal growth restriction (FGR), gestational diabetes mellitus (GDM), preterm birth, and chronic venous disease [...].

Department of Molecular Biology and Cell Pathology 3rd Faculty of Medicine Charles University 10000 Prague Czech Republic

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Gerasimova E.M., Fedotov S.A., Kachkin D.V., Vashukova E.S., Glotov A.S., Chernoff Y.O., Rubel A.A. Protein Misfolding during Pregnancy: New Approaches to Preeclampsia Diagnostics. Int. J. Mol. Sci. 2019;20:6183. doi: 10.3390/ijms20246183. PubMed DOI PMC

Ziganshina M.M., Yarotskaya E.L., Bovin N.V., Pavlovich S.V., Sukhikh G.T. Can Endothelial Glycocalyx Be a Major Morphological Substrate in Pre-Eclampsia? Int. J. Mol. Sci. 2020;21:3048. doi: 10.3390/ijms21093048. PubMed DOI PMC

Alejandro E.U., Mamerto T.P., Chung G., Villavieja A., Gaus N.L., Morgan E., Pineda-Cortel M.R.B. Gestational Diabetes Mellitus: A Harbinger of the Vicious Cycle of Diabetes. Int. J. Mol. Sci. 2020;21:5003. doi: 10.3390/ijms21145003. PubMed DOI PMC

Hromadnikova I., Kotlabova K., Dvorakova L., Krofta L. Evaluation of Vascular Endothelial Function in Young and Middle-Aged Women with Respect to a History of Pregnancy, Pregnancy-Related Complications, Classical Cardiovascular Risk Factors, and Epigenetics. Int. J. Mol. Sci. 2020;21:430. doi: 10.3390/ijms21020430. PubMed DOI PMC

Szilagyi A., Gelencser Z., Romero R., Xu Y., Kiraly P., Demeter A., Palhalmi J., Gyorffy B.A., Juhasz K., Hupuczi P., et al. Placenta-Specific Genes, Their Regulation During Villous Trophoblast Differentiation and Dysregulation in Preterm Preeclampsia. Int. J. Mol. Sci. 2020;21:628. doi: 10.3390/ijms21020628. PubMed DOI PMC

Starodubtseva N., Nizyaeva N., Baev O., Bugrova A., Gapaeva M., Muminova K., Kononikhin A., Frankevich V., Nikolaev E., Sukhikh G. SERPINA1 Peptides in Urine as A Potential Marker of Preeclampsia Severity. Int. J. Mol. Sci. 2020;21:914. doi: 10.3390/ijms21030914. PubMed DOI PMC

Hromadnikova I., Kotlabova K., Dvorakova L., Krofta L. Diabetes Mellitus and Cardiovascular Risk Assessment in Mothers with a History of Gestational Diabetes Mellitus Based on Postpartal Expression Profile of MicroRNAs Associated with Diabetes Mellitus and Cardiovascular and Cerebrovascular Diseases. Int. J. Mol. Sci. 2020;21:2437. doi: 10.3390/ijms21072437. PubMed DOI PMC

Ortega M.A., Saez M.A., Fraile-Martínez O., Asúnsolo Á., Pekarek L., Bravo C., Coca S., Sainz F., Mon M.Á., Buján J., et al. Increased Angiogenesis and Lymphangiogenesis in the Placental Villi of Women with Chronic Venous Disease during Pregnancy. Int. J. Mol. Sci. 2020;21:2487. doi: 10.3390/ijms21072487. PubMed DOI PMC

Lacroix G., Gouyer V., Gottrand F., Desseyn J.L. The Cervicovaginal Mucus Barrier. Int. J. Mol. Sci. 2020;21:8266. doi: 10.3390/ijms21218266. PubMed DOI PMC

Szczuko M., Kikut J., Komorniak N., Bilicki J., Celewicz Z., Ziętek M. The Role of Arachidonic and Linoleic Acid Derivatives in Pathological Pregnancies and the Human Reproduction Process. Int. J. Mol. Sci. 2020;21:9628. doi: 10.3390/ijms21249628. PubMed DOI PMC

Todros T., Paulesu L., Cardaropoli S., Rolfo A., Masturzo B., Ermini L., Romagnoli R., Ietta F. Role of the Macrophage Migration Inhibitory Factor in the Pathophysiology of Pre-Eclampsia. Int. J. Mol. Sci. 2021;22:1823. doi: 10.3390/ijms22041823. PubMed DOI PMC

Matsubara K., Matsubara Y., Uchikura Y., Sugiyama T. Pathophysiology of Preeclampsia: The Role of Exosomes. Int. J. Mol. Sci. 2021;22:2572. doi: 10.3390/ijms22052572. PubMed DOI PMC

Ornoy A., Becker M., Weinstein-Fudim L., Ergaz Z. Diabetes during Pregnancy: A Maternal Disease Complicating the Course of Pregnancy with Long-Term Deleterious Effects on the Offspring. A Clinical Review. Int. J. Mol. Sci. 2021;22:2965. doi: 10.3390/ijms22062965. PubMed DOI PMC

Pankiewicz K., Fijałkowska A., Issat T., Maciejewski T.M. Insight into the Key Points of Preeclampsia Pathophysiology: Uterine Artery Remodeling and the Role of MicroRNAs. Int. J. Mol. Sci. 2021;22:3132. doi: 10.3390/ijms22063132. PubMed DOI PMC

Ruszała M., Niebrzydowska M., Pilszyk A., Kimber-Trojnar Ż., Trojnar M., Leszczyńska-Gorzelak B. Novel Biomolecules in the Pathogenesis of Gestational Diabetes Mellitus. Int. J. Mol. Sci. 2021;22:11578. doi: 10.3390/ijms222111578. PubMed DOI PMC

Bendek M.J., Canedo-Marroquín G., Realini O., Retamal I.N., Hernández M., Hoare A., Busso D., Monteiro L.J., Illanes S.E., Chaparro A. Periodontitis and Gestational Diabetes Mellitus: A Potential Inflammatory Vicious Cycle. Int. J. Mol. Sci. 2021;22:11831. doi: 10.3390/ijms222111831. PubMed DOI PMC

Deval G., Boland S., Fournier T., Ferecatu I. On Placental Toxicology Studies and Cerium Dioxide Nanoparticles. Int. J. Mol. Sci. 2021;22:12266. doi: 10.3390/ijms222212266. PubMed DOI PMC

Kelemu T., Erlandsson L., Seifu D., Abebe M., Teklu S., Storry J.R., Hansson S.R. Association of Maternal Regulatory Single Nucleotide Polymorphic CD99 Genotype with Preeclampsia in Pregnancies Carrying Male Fetuses in Ethiopian Women. Int. J. Mol. Sci. 2020;21:5837. doi: 10.3390/ijms21165837. PubMed DOI PMC

Pasternak Y., Biron-Shental T., Ohana M., Einbinder Y., Arbib N., Benchetrit S., Zitman-Gal T. Gestational Diabetes Type 2: Variation in High-Density Lipoproteins Composition and Function. Int. J. Mol. Sci. 2020;21:6281. doi: 10.3390/ijms21176281. PubMed DOI PMC

Burzynska-Pedziwiatr I., Jankowski A., Kowalski K., Sendys P., Zieleniak A., Cypryk K., Zurawska-Klis M., Wozniak L.A., Bukowiecka-Matusiak M. Associations of Arginine with Gestational Diabetes Mellitus in a Follow-Up Study. Int. J. Mol. Sci. 2020;21:7811. doi: 10.3390/ijms21217811. PubMed DOI PMC

Keckstein S., Pritz S., Amann N., Meister S., Beyer S., Jegen M., Kuhn C., Hutter S., Knabl J., Mahner S., et al. Sex Specific Expression of Interleukin 7, 8 and 15 in Placentas of Women with Gestational Diabetes. Int. J. Mol. Sci. 2020;21:8026. doi: 10.3390/ijms21218026. PubMed DOI PMC

Hromadnikova I., Kotlabova K., Krofta L., Sirc J. Association Analysis in Children Born from Normal and Complicated Pregnancies-Cardiovascular Disease Associated microRNAs and the Incidence of Prehypertension/Hypertension, Overweight/Obesity, Valve Problems and Heart Defects. Int. J. Mol. Sci. 2020;21:8413. doi: 10.3390/ijms21218413. PubMed DOI PMC

Kedziora S.M., Kräker K., Markó L., Binder J., Sugulle M., Gauster M., Müller D.N., Dechend R., Haase N., Herse F. Kidney Injury Caused by Preeclamptic Pregnancy Recovers Postpartum in a Transgenic Rat Model. Int. J. Mol. Sci. 2021;22:3762. doi: 10.3390/ijms22073762. PubMed DOI PMC