Pulmonary Complications after COVID-19
Status PubMed-not-MEDLINE Language English Country Switzerland Media electronic
Document type Journal Article
Grant support
DRO FNOL 00098892
University Hospital Olomouc
IGA_LF_2022_018
Palacký University Olomouc
AZV NU22-B-112
Czech Health Research Council
PubMed
35330108
PubMed Central
PMC8955291
DOI
10.3390/life12030357
PII: life12030357
Knihovny.cz E-resources
- Keywords
- bacterial respiratory infections, long COVID-19, pulmonary complications,
- Publication type
- Journal Article MeSH
Coronavirus disease 2019 (COVID-19) is a threat to patients not only because of its acute course, but also because of various complications occurring in the following period, that is, more than 28 days after the onset of acute infection. The present study identified a total of 121 patients hospitalized 29 or more days after the first positive result of a PCR test for SARS-CoV-2, of whom 98 patients were included in the study. Patients were divided into two groups by the time interval between the positive COVID-19 test result and hospitalization date. The time intervals were week 5-11 in an ongoing-COVID group (57.1% of patients) and 12 or more weeks in a post-COVID-group (42.9%). The most frequent reason for hospitalization was respiratory tract infection (58.2%). Pneumonia accounted for 77.2% of these cases. Other reasons for hospitalization were interstitial lung disease (22.4%), pulmonary embolism (8.2%), and sarcoidosis (6.1%). The study group was further divided according to the causes of hospitalization into subgroups with infections and other causes. In the group with infectious diseases, there was a shorter time period between PCR positivity and hospitalization and there were significantly more frequent non-respiratory complications. In the entire sample, the in-hospital mortality was 5.1%.
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Shah W., Hillman T., Playford E.D., Hishmeh L. Managing the long term effects of COVID-19: Summary of NICE, SIGN, and RCGP rapid guideline. BMJ. 2021;372:n136. doi: 10.1136/bmj.n136. PubMed DOI
Oronsky B., Larson C., Hammond T.C., Oronsky A., Kesari S., Lybeck M., Reid T.R. A Review of Persistent Post-COVID Syndrome (PPCS) Clin. Rev. Allergy Immunol. 2021;20:114. doi: 10.1007/s12016-021-08848-3. PubMed DOI PMC
Hamers L., Kox M., Pickkers P. Sepsis-induced immunoparalysis: Mechanisms, markers, and treatment options. Minerva Anestesiol. 2015;81:426–439. PubMed
Xu K., Cai H., Shen Y., Ni Q., Chen Y., Hu S., Li J., Wang H., Yu L., Huang H., et al. Management of corona virus disease-19 (COVID-19): The Zhejiang experience. Zhejiang Da Xue Xue Bao Yi Xue Ban J. Zhejiang Univ. Med. Sci. 2020;49:147–157. PubMed PMC
Shi H., Han X., Jiang N., Cao Y., Alwalid O., Gu J., Fan Y., Zheng C. Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: A descriptive study. Lancet Infect. Dis. 2020;20:425–434. doi: 10.1016/S1473-3099(20)30086-4. PubMed DOI PMC
Yong S.J. Long COVID or post-COVID-19 syndrome: Putative pathophysiology, risk factors, and treatments. Infect. Dis. 2021;53:737–754. doi: 10.1080/23744235.2021.1924397. PubMed DOI PMC
Hosey M.M., Needham D.M. Survivorship after COVID-19 ICU stay. Nat. Rev. Dis. Primers. 2020;6:60. doi: 10.1038/s41572-020-0201-1. PubMed DOI PMC
Becker R.C. COVID-19 and its sequelae: A platform for optimal patient care, discovery and training. J. Thromb. Thrombolysis. 2021;51:587–594. doi: 10.1007/s11239-021-02375-w. PubMed DOI PMC
Havervall S., Rosell A., Phillipson M., Mangsbo S.M., Nilsson P., Hober S., Thålin C. Symptoms and Functional Impairment Assessed 8 Months After Mild COVID-19 Among Health Care Workers. JAMA. 2021;325:2015–2016. doi: 10.1001/jama.2021.5612. PubMed DOI PMC
COVID 19 Long Term Health Effects. [(accessed on 7 May 2021)]; Available online: https://www.gov.uk/government/publications/covid-19-long-term-health-effects/covid-19-long-term-health-effects.
Tenforde M.W., Kim S.S., Lindsell C.J., Billig Rose E., Shapiro N.I., Files D.C., Gibbs K.W., Erickson H.L., Steingrub J.S., Smithline H.A., et al. Symptom Duration and Risk Factors for Delayed Return to Usual Health Among Outpatients with COVID-19 in a Multistate Health Care Systems Network—United States, March–June 2020. MMWR Morb. Mortal. Wkly. Rep. 2020;69:993–998. doi: 10.15585/mmwr.mm6930e1. PubMed DOI PMC
Carvalho-Schneider C., Laurent E., Lemaignen A., Beaufils E., Bourbao-Tournois C., Laribi S., Flament T., Ferreira-Maldent N., Bruyère F., Stefic K., et al. Follow-up of adults with noncritical COVID-19 two months after symptom onset. Clin. Microbiol. Infect. 2021;27:258–263. doi: 10.1016/j.cmi.2020.09.052. PubMed DOI PMC
Greenhalgh T., Knight M., A’Court C., Buxton M., Husain L. Management of post-acute COVID-19 in primary care. BMJ. 2020;370:m3026. doi: 10.1136/bmj.m3026. PubMed DOI
Office for National Statistics (ONS) The Prevalence of Long COVID Symptoms and COVID-19 Complications. [(accessed on 6 December 2021)]; Available online: https://www.ons.gov.uk/news/statementsandletters/theprevalenceoflongcovidsymptomsandcovid19complications.
Sonnweber T., Sahanic S., Pizzini A., Luger A., Schwabl C., Sonnweber B., Kurz K., Koppelstätter S., Haschka D., Petzer V., et al. Cardiopulmonary recovery after COVID-19: An observational prospective multicentre trial. Eur. Respir. J. 2021;57:2003481. doi: 10.1183/13993003.03481-2020. PubMed DOI PMC
Arnold D.T., Hamilton F.W., Milne A., Morley A.J., Viner J., Attwood M., Noel A., Gunning S., Hatrick J., Hamilton S., et al. Patient outcomes after hospitalisation with COVID-19 and implications for follow-up: Results from a prospective UK cohort. Thorax. 2020;76:399–401. doi: 10.1136/thoraxjnl-2020-216086. PubMed DOI PMC
Xiong Q., Xu M., Li J., Liu Y., Zhang J., Xu Y., Dong W. Clinical sequelae of COVID-19 survivors in Wuhan, China: A single-centre longitudinal study. Clin. Microbiol. Infect. 2021;27:89–95. doi: 10.1016/j.cmi.2020.09.023. PubMed DOI PMC
Petersen M.S., Kristiansen M.F., Hanusson K.D., Danielsen M.E., Steig B.Á., Gaini S., Strøm M., Weihe P. Long COVID in the Faroe Islands-a longitudinal study among non-hospitalized patients. Clin. Infect. Dis. 2020;73:e4058–e4063. doi: 10.1093/cid/ciaa1792. PubMed DOI PMC
Goërtz Y.M.J., Van Herck M., Delbressine J.M., Vaes A.W., Meys R., Machado F.V.C., Houben-Wilke S., Burtin C., Posthuma R., Franssen F.M.E., et al. Persistent symptoms 3 months after a SARS-CoV-2 infection: The post-COVID-19 syndrome? ERJ Open Res. 2020;6:e00542-2020. doi: 10.1183/23120541.00542-2020. PubMed DOI PMC
Chopra V., Flanders S.A., O’Malley M. Sixty-day outcomes among patients hospitalized with COVID-19. Ann. Intern. Med. 2020;174:576–587. doi: 10.7326/M20-5661. PubMed DOI PMC
Centers for Disease Control and Prevention Late Sequelae of COVID-19. [(accessed on 5 January 2021)]; Available online: https://www.cdc.gov/coronavirus/2019-ncov/hcp/clinical-care/late-sequelae.html.
Cirulli E.T., Schiabor Barrett K.M., Riffle S., Bolze A., Neveux I., Dabe S., Grzymski J.J., Lu J.T., Washington N.L. Long-term COVID-19 symptoms in a large unselected population. medRxiv. 2020 doi: 10.1101/2020.10.07.20208702. DOI
Carfì A., Bernabei R., Landi F., Gemelli Against COVID-19 PostAcute Care Study Group Persistent Symptoms in Patients after Acute COVID-19. JAMA. 2020;324:603–605. doi: 10.1001/jama.2020.12603. PubMed DOI PMC
European Committee on Antimicrobial Susceptibility Testing Breakpoint Tables for Interpretation of MICs and Zone Diameters. [(accessed on 6 December 2021)]. Available online: http://www.eucast.org/clinical_breakpoints.
Aiyegbusi O.L., Hughes S.E., Turner G., Rivera S.C., McMullan C., Chandan J.S., Haroon S., Price G., Davies E.H., Nirantharakumar K., et al. TLC Study Group. Symptoms, complications and management of long COVID: A review. J. R. Soc. Med. 2021;114:428–442. doi: 10.1177/01410768211032850. PubMed DOI PMC
Huang C., Huang L., Wang Y., Li X., Ren L., Gu X., Kang L., Guo L., Liu M., Zhou X., et al. 6-month consequences of COVID-19 in patients discharged from hospital: A cohort study. Lancet. 2021;397:220–232. doi: 10.1016/S0140-6736(20)32656-8. PubMed DOI PMC
Bellan M., Soddu D., Balbo P.E., Baricich A., Zeppegno P., Avanzi G.C., Baldon G., Bartolomei G., Battaglia M., Battistini S., et al. Respiratory and psychophysical sequelae among patients with COVID-19 four months after hospital discharge. JAMA Netw. Open. 2021;4:e2036142. doi: 10.1001/jamanetworkopen.2020.36142. PubMed DOI PMC
Taquet M., Geddes J.R., Husain M., Luciano S., Harrison P.J. 6-month neurological and psychiatric outcomes in 236 379 survivors of COVID-19: A retrospective cohort study using electronic health records. Lancet Psychiatry. 2021;8:416–427. doi: 10.1016/S2215-0366(21)00084-5. PubMed DOI PMC
Halpin S.J., McIvor C., Whyatt G., Adams A., Harvey O., McLean L., Walshaw C., Kemp S., Corrado J., Singh R., et al. Postdischarge symptoms and rehabilitation needs in survivors of COVID-19 infection: A cross-sectional evaluation. J. Med. Virol. 2021;93:1013–1022. doi: 10.1002/jmv.26368. PubMed DOI
Davis H.E., Assaf G.S., McCorkell L., Wei H., Low R.J., Re’em Y., Redfield S., Austin J.P., Akrami A. Characterizing long COVID in an international cohort: 7 months of symptoms and their impact. EClinicalMedicine. 2021;38:101019. doi: 10.1016/j.eclinm.2021.101019. PubMed DOI PMC
Mandal S., Barnett J., Brill S.E., Brown J.S., Denneny E.K., Hare S.S., Heightman M., Hillman T.E., Jacob J., Jarvis H.C., et al. ‘Long-COVID’: A cross-sectional study of persisting symptoms, biomarker and imaging abnormalities following hospitalisation for COVID-19. Thorax. 2021;76:396–398. doi: 10.1136/thoraxjnl-2020-215818. PubMed DOI PMC
D’Cruz R.F., Waller M.D., Perrin F., Periselneris J., Norton S., Smith L.J., Patrick T., Walder D., Heitmann A., Lee K., et al. Chest radiography is a poor predictor of respiratory symptoms and functional impairment in survivors of severe COVID-19 pneumonia. ERJ Open Res. 2021;7:e00655-2020. doi: 10.1183/23120541.00655-2020. PubMed DOI PMC
Shi S., Qin M., Shen B., Cai Y., Liu T., Yang F., Gong W., Liu X., Liang J., Zhao Q., et al. Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China. JAMA Cardiol. 2020;5:802–810. doi: 10.1001/jamacardio.2020.0950. PubMed DOI PMC
Gasecka A., Pruc M., Kukula K., Gilis-Malinowska N., Filipiak K.J., Jaguszewski M.J., Szarpak L. Post-COVID-19 heart syndrome. Cardiol. J. 2021;28:353–354. doi: 10.5603/CJ.a2021.0028. PubMed DOI PMC
Lu Y., Li X., Geng D., Mei N., Wu P.Y., Huang C.C., Jia T., Zhao Y., Wang D., Xiao A., et al. Cerebral micro-structural changes in COVID-19 patients—An MRI-based 3-month follow-up study. EClinicalMedicine. 2020;25:100484. doi: 10.1016/j.eclinm.2020.100484. PubMed DOI PMC
Stevens J.S., King K.L., Robbins-Juarez S.Y., Khairallah P., Toma K., Alvarado Verduzco H., Daniel E., Douglas D., Moses A.A., Peleg Y., et al. High rate of renal recovery in survivors of COVID-19 associated acute renal failure requiring renal replacement therapy. PLoS ONE. 2020;15:e0244131. doi: 10.1371/journal.pone.0244131. PubMed DOI PMC
Velez J.C.Q., Caza T., Larsen C.P. COVAN is the new HIVAN: The re-emergence of collapsing glomerulopathy with COVID-19. Nat. Rev. Nephrol. 2020;16:565–567. doi: 10.1038/s41581-020-0332-3. PubMed DOI PMC
Zuo T., Zhang F., Lui G., Yeoh Y.K., Li A., Zhan H., Wan Y., Chung A., Cheung C.P., Chen N., et al. Alterations in Gut Microbiota of Patients With COVID-19 During Time of Hospitalization. Gastroenterology. 2020;159:944–955.e8. doi: 10.1053/j.gastro.2020.05.048. PubMed DOI PMC
Donati Zeppa S., Agostini D., Piccoli G., Stocchi V., Sestili P. Gut Microbiota Status in COVID-19: An Unrecognized Player? Front. Cell. Infect. Microbiol. 2020;10:576551. doi: 10.3389/fcimb.2020.576551. PubMed DOI PMC
Bogdanová K., Doubravská L., Vágnerová I., Hricová K., Pudová V., Röderová M., Papajk J., Uvízl R., Langová K., Kolář M. Clostridioides difficile and Vancomycin-Resistant Enterococci in COVID-19 Patients with Severe Pneumonia. Life. 2021;11:1127. doi: 10.3390/life11111127. PubMed DOI PMC
Suwanwongse K., Shabarek N. Newly diagnosed diabetes mellitus, DKA, and COVID-19: Causality or coincidence? A report of three cases. J. Med. Virol. 2020;93:1150–1153. doi: 10.1002/jmv.26339. PubMed DOI PMC
Tee L.Y., Harjanto S., Rosario B.H. COVID-19 complicated by Hashimoto’s thyroiditis. Singap. Med. J. 2021;62:265. doi: 10.11622/smedj.2020106. PubMed DOI PMC
Mateu-Salat M., Urgell E., Chico A. SARS-CoV-2 as a trigger for autoimmune disease: Report of two cases of Graves’ disease after COVID-19. J. Endocrinol. Investig. 2020;43:1527–1528. doi: 10.1007/s40618-020-01366-7. PubMed DOI PMC
Ayoubkhani D., Khunti K., Nafilyan V., Maddox T., Humberstone B., Diamond I., Banerjee A. Post-COVID syndrome in individuals admitted to hospital with COVID-19: Retrospective cohort study. BMJ. 2021;372:n693. doi: 10.1136/bmj.n693. PubMed DOI PMC
Sudre C.H., Murray B., Varsavsky T., Graham M.S., Penfold R.S., Bowyer R.C., Pujol J.C., Klaser K., Antonelli M., Canas L.S., et al. Attributes and predictors of Long-COVID. Nat. Med. 2021;27:626–631. doi: 10.1038/s41591-021-01292-y. PubMed DOI PMC
Jacobs L.G., Gourna Paleoudis E., Lesky-Di Bari D., Nyirenda T., Friedman T., Gupta A., Rasouli L., Zetkulic M., Balani B., Ogedegbe C., et al. Persistence of symptoms and quality of life at 35 days after hospitalization for COVID-19 infection. PLoS ONE. 2020;15:e0243882. doi: 10.1371/journal.pone.0243882. PubMed DOI PMC
Stavem K., Ghanima W., Olsen M.K., Gilboe H.M., Einvik G. Persistent symptoms 1.5–6 months after COVID-19 in non-hospitalised subjects: A population-based cohort study. Thorax. 2020;76:405–407. doi: 10.1136/thoraxjnl-2020-216377. PubMed DOI PMC
Galal I., Hussein A., Amin M.T., Saad M.M., Zayan H., Abdelsayed M.Z., Moustafa M.M., Ezzat A.R., Helmy R., Abd_Elaal H.K., et al. Determinants of persistent post-COVID-19 symptoms: Value of a novel COVID-19 symptom score. Egypt. J. Bronchol. 2021;15:10. doi: 10.1186/s43168-020-00049-4. DOI
Wang Y., Dong C., Hu Y., Li C., Ren Q., Zhang X., Shi H., Zhou M. Temporal changes of CT findings in patients with COVID-19 pneumonia: A longitudinal study. Radiology. 2020;296:E55–E64. doi: 10.1148/radiol.2020200843. PubMed DOI PMC
Wu X., Liu X., Zhou Y., Yu H., Li R., Zhan Q., Ni F., Fang S., Lu Y., Ding X., et al. 3-month, 6-month, 9-month, and 12-month respiratory outcomes in patients following COVID-19-related hospitalisation: A prospective study. Lancet Respir. Med. 2021;9:747–754. doi: 10.1016/S2213-2600(21)00174-0. PubMed DOI PMC
Torres-Castro R., Vasconcello-Castillo L., Alsina-Restoy X., Solis-Navarro L., Burgos F., Puppo H., Vilaró J. Respiratory function in patients post-infection by COVID-19: A systematic review and meta-analysis. Pulmonology. 2021;27:328–337. doi: 10.1016/j.pulmoe.2020.10.013. PubMed DOI PMC
Lerum T.V., Aaløkken T.M., Brønstad E., Aarli B., Ikdahl E., Lund K., Durheim M.T., Rodriguez J.R., Meltzer C., Tonby K., et al. Dyspnoea, lung function and CT findings three months after hospital admission for COVID-19. Eur. Respir. J. 2020;57:2003448. doi: 10.1183/13993003.03448-2020. PubMed DOI PMC
Zhao Y.M., Shang Y.M., Song W.B., Li Q.Q., Xie H., Xu Q.F., Jia J.L., Li L.M., Mao H.L., Zhou X.M., et al. Follow-up study of the pulmonary function and related physiological characteristics of COVID-19 survivors three months after recovery. EClinicalMedicine. 2020;25:100463. doi: 10.1016/j.eclinm.2020.100463. PubMed DOI PMC
Van den Borst B., Peters J.B., Brink M., Schoon Y., Bleeker-Rovers C.P., Schers H., van Hees H., van Helvoort H., van den Boogaard M., van der Hoeven H., et al. Comprehensive health assessment three months after recovery from acute COVID-19. Clin. Infect. Dis. 2021;73:e1089. doi: 10.1093/cid/ciaa1750. PubMed DOI PMC
Moreno-Pérez O., Merino E., Leon-Ramirez J.M., Andres M., Ramos J.M., Arenas-Jiménez J., Asensio S., Sanchez R., Ruiz-Torregrosa P., Galan I., et al. Post-acute COVID-19 syndrome. Incidence and risk factors: A Mediterranean cohort study. J. Infect. 2021;82:378–383. doi: 10.1016/j.jinf.2021.01.004. PubMed DOI PMC
Tabatabaei S.M.H., Rajebi H., Moghaddas F., Ghasemiadl M., Talari H. Chest CT in COVID-19 pneumonia: What are the findings in mid-term follow-up? Emerg. Radiol. 2020;27:711–719. doi: 10.1007/s10140-020-01869-z. PubMed DOI PMC
Shah A.S., Wong A.W., Hague C.J., Murphy D.T., Johnston J.C., Ryerson C.J., Carlsten C. A prospective study of 12-week respiratory outcomes in COVID-19-related hospitalisations. Thorax. 2020;76:402–404. doi: 10.1136/thoraxjnl-2020-216308. PubMed DOI
Korompoki E., Gavriatopoulou M., Hicklen R.S., Ntanasis-Stathopoulos I., Kastritis E., Fotiou D., Stamatelopoulos K., Terpos E., Kotanidou A., Hagberg C.A. Epidemiology and organ specific sequelae of post-acute COVID19: A narrative review. J. Infect. 2021;83:1–16. doi: 10.1016/j.jinf.2021.05.004. PubMed DOI PMC
Zoumot Z., Bonilla M.F., Wahla A.S., Shafiq I. Pulmonary cavitation: An under-recognized late complication of severe COVID-19 lung disease. BMC Pulm. Med. 2021;21:24. doi: 10.1186/s12890-020-01379-1. PubMed DOI PMC
Ramzi Z.S. Hospital readmissions and post-discharge all-cause mortality in COVID-19 recovered patients: A systematic review and meta-analysis. Am. J. Emerg. Med. 2021;51:267–279. doi: 10.1016/j.ajem.2021.10.059. PubMed DOI PMC
Atalla E., Kalligeros M., Giampaolo G., Mylona E.K., Shehadeh F., Mylonakis E. Readmissions among patients with COVID-19. Int. J. Clin. Pract. 2021;75:e13700. doi: 10.1111/ijcp.13700. PubMed DOI
Lavery A.M., Preston L.E., Ko J.Y., Chevinsky J.R., DeSisto C.L., Pennington A.F., Kompaniyets L., Datta S.D., Click E.S., Golden T., et al. Characteristics of Hospitalized COVID-19 Patients Discharged and Experiencing Same-Hospital Readmission—United States, March–August 2020. MMWR Morb. Mortal. Wkly. Rep. 2020;69:1695–1699. doi: 10.15585/mmwr.mm6945e2. PubMed DOI PMC
Parra L.M., Cantero M., Morrás I., Vallejo A., Diego I., Jiménez-Tejero E., Múñez E., Asensio Á., Fermández-Cruz A., Ramos-Martinez A., et al. Hospital Readmissions of Discharged Patients with COVID-19. Int. J. Gen. Med. 2020;13:1359–1366. doi: 10.2147/IJGM.S275775. PubMed DOI PMC
Ramos-Martínez A., Parra-Ramírez L.M., Morrás I., Carnevali M., Jiménez-Ibañez L., Rubio-Rivas M., Arnalich F., Beato J.L., Monge D., Asín U., et al. Frequency, risk factors, and outcomes of hospital readmissions of COVID-19 patients. Sci. Rep. 2021;11:13733. doi: 10.1038/s41598-021-93076-0. PubMed DOI PMC
Kirkegaard C., Falcó-Roget A., Sánchez-Montalvá A., Valls Á., Clofent D., Campos-Varela I., García-García S., Leguízamo L.M., Sellarès-Nadal J., Eremiev S., et al. Incidence and risk factors for early readmission after hospitalization for SARS-CoV-2 infection: Results from a retrospective cohort study. Infection. 2021;2:1. doi: 10.1007/s15010-021-01662-1. PubMed DOI PMC
Yeo I., Baek S., Kim J., Elshakh H., Voronina A., Lou M.S., Vapnik J., Kaler R., Dai X., Goldbarg S. Assessment of thirty-day readmission rate, timing, causes and predictors after hospitalization with COVID-19. J. Intern. Med. 2021;290:157–165. doi: 10.1111/joim.13241. PubMed DOI PMC
Donnelly J., Qing Wang X., Iwashyna T. Readmission and Death After Initial Hospital Discharge Among Patients with COVID-19 in a Large Multihospital System. JAMA. 2021;325:304–306. doi: 10.1001/jama.2020.21465. PubMed DOI PMC
Clark J.R., Batra A., Shlobin N.A., Hoffman S.C., Orban Z.S., Koralnik I.J., Liotta E.M. Acute-care hospital reencounters in COVID-19 patients. GeroScience. 2021;43:2041–2053. doi: 10.1007/s11357-021-00378-2. PubMed DOI PMC
Günster C., Busse R., Spoden M., Rombey T., Schillinger G., Hoffmann W., Weber-Carstens S., Schuppert A., Karagiannidis C. 6-month mortality and readmissions of hospitalized COVID-19 patients: A nationwide cohort study of 8679 patients in Germany. PLoS ONE. 2021;16:e0255427. doi: 10.1371/journal.pone.0255427. PubMed DOI PMC
Romero-Duarte Á., Rivera-Izquierdo M., Guerrero-Fernández de Alba I., Pérez-Contreras M., Fernández-Martínez N.F., Ruiz-Montero R., Serrano-Ortiz Á., González-Serna R.O., Salcedo-Leal I., Jiménez-Mejías E., et al. Sequelae, persistent symptomatology and outcomes after COVID-19 hospitalization: The ANCOHVID multicentre 6-month follow-up study. BMC Med. 2021;19:129. doi: 10.1186/s12916-021-02003-7. PubMed DOI PMC
Guarin G., Lo K.B., Bhargav R., Salacup G., Wattoo A., Coignet J.G., DeJoy R., Azmaiparashvili Z., Patarroyo-Aponte G., Eiger G., et al. Factors associated with hospital readmissions among patients with COVID-19: A single-center experience. J. Med. Virol. 2021;93:5582–5587. doi: 10.1002/jmv.27104. PubMed DOI PMC
Zhou F., Yu T., Du R., Fan G., Liu Y., Liu Z., Xiang J., Wang Y., Song B., Gu X., et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study. Lancet. 2020;395:1054–1062. doi: 10.1016/S0140-6736(20)30566-3. PubMed DOI PMC
Ambardar S.R., Hightower S.L., Huprikar N.A., Chung K.K., Singhal A., Collen J.F. Post-COVID-19 Pulmonary Fibrosis: Novel Sequelae of the Current Pandemic. J. Clin. Med. 2021;10:2452. doi: 10.3390/jcm10112452. PubMed DOI PMC
Huang W., Wu Q., Chen Z., Xiong Z., Wang K., Tian J., Zhang S. The potential indicators for pulmonary fibrosis in survivors of severe COVID-19. J. Infect. 2021;82:e5–e7. doi: 10.1016/j.jinf.2020.09.027. PubMed DOI PMC
Yu M., Liu Y., Xu D., Zhang R., Lan L., Xu H. Prediction of the development of pulmonary fibrosis using serial thin-section CT and clinical features in patients discharged after treatment for COVID-19 pneumonia. Korean J. Radiol. 2020;21:746–755. doi: 10.3348/kjr.2020.0215. PubMed DOI PMC
Hu Z.J., Xu J., Yin J.M., Li L., Hou W., Zhang L.L., Zhou Z., Yu Y.Z., Li H.J., Feng Y.M., et al. Lower circulating interferon-gamma is a risk factor for lung fibrosis in COVID-19 patients. Front. Immunol. 2020;11:585647. doi: 10.3389/fimmu.2020.585647. PubMed DOI PMC
Huang C., Wang Y., Li X., Ren L., Zhao J., Hu Y., Zhang L., Fan G., Xu J., Gu X., et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395:497–506. doi: 10.1016/S0140-6736(20)30183-5. PubMed DOI PMC
Halpin D.M.G., Singh D., Hadfield R.M. Inhaled corticosteroids and COVID-19: A systematic review and clinical perspective. Eur. Respir. J. 2020;55:2001009. doi: 10.1183/13993003.01009-2020. PubMed DOI PMC
Sokolowska M., Lukasik Z.M., Agache I., Akdis C.A., Akdis D., Akdis M., Barcik W., Brough H.A., Eiwegger T., Eljaszewicz A., et al. Immunology of COVID-19: Mechanisms, clinical outcome, diagnostics, and perspectives-A report of the European Academy of Allergy and Clinical Immunology (EAACI) Allergy. 2020;75:2445–2476. doi: 10.1111/all.14462. PubMed DOI PMC
Zeng Q.L., Li G.M., Ji F., Ma S.H., Zhang G.F., Xu J.H., Lin W.B., Xu G.H., Zhang G.Q., Li G.T., et al. Clinical course and treatment efficacy of COVID-19 near Hubei Province, China: A multicentre, retrospective study. Transbound. Emerg. Dis. 2020;67:2971–2982. doi: 10.1111/tbed.13674. PubMed DOI PMC
Ye Z., Zhang Y., Wang Y., Huang Z., Song B. Chest CT manifestations of new coronavirus disease 2019 (COVID-19): A pictoral review. Eur. Radiol. 2020;30:4381–4389. doi: 10.1007/s00330-020-06801-0. PubMed DOI PMC
Vadukul P., Sharma D., Vincent P. Massive pulmonary embolism following recovery from COVID-19 infection: Inflammation, thrombosis and the role of extended thromboprophylaxis. BMJ Case Rep. 2020;13:e238168. doi: 10.1136/bcr-2020-238168. PubMed DOI PMC
Taha M., Nguyen P., Sharma A., Taha M., Samavati L. Forty-One-Year-Old Man with Pulmonary Embolism 5 Months After COVID-19. Clin. Med. Insights Circ. Respir. Pulm. Med. 2021;15:1179548420986659. doi: 10.1177/1179548420986659. PubMed DOI PMC
Vechi H.T., Maia L.R., Alves M.D.M. Late acute pulmonary embolism after mild Coronavirus Disease 2019 (COVID-19): A case series. Rev. Inst. Med. Trop. Sao Paulo. 2020;62:e63. doi: 10.1590/s1678-9946202062063. PubMed DOI PMC