Civilization factors are responsible for the increasing of human exposure to mycobacteria from environment, water, and food during the last few decades. Urbanization, lifestyle changes and new technologies in the animal and plant industry are involved in frequent contact of people with mycobacteria. Type 1 diabetes is a multifactorial polygenic disease; its origin is conditioned by the mutual interaction of genetic and other factors. The environmental factors and certain pathogenetic pathways are shared by some immune mediated chronic inflammatory and autoimmune diseases, which are associated with triggers originating mainly from Mycobacterium avium subspecies paratuberculosis, an intestinal pathogen which persists in the environment. Type 1 diabetes and some other chronic inflammatory diseases thus pose the global health problem which could be mitigated by measures aimed to decrease the human exposure to this neglected zoonotic mycobacterium.

AOU Sassari UC Microbiologia e Virologia 07100 Sassari Italy

Dipartimento di Scienze Biomediche Sezione di Microbiologia Sperimentale e Clinica Università degli Studi di Sassari 07100 Sassari Italy

Faculty of Pharmacy Masaryk University 612 00 Brno Czech Republic

Institute for Research and Education 621 00 Brno Czech Republic

Orlova Department Karvina Raj Hospital 734 01 Karvina Czech Republic

Veterinary Research Institute 612 00 Brno Czech Republic

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