Key Role of Multidisciplinary Collaboration towards Global Elimination of HCV Infection
Language English Country Switzerland Media electronic
Document type Journal Article
PubMed
35409839
PubMed Central
PMC8998758
DOI
10.3390/ijerph19074158
PII: ijerph19074158
Knihovny.cz E-resources
- Keywords
- HCV, HCV infection, PWID, WHO, global HCV elimination plan, hepatitis C virus, people who inject drugs, viral hepatitis C,
- MeSH
- Antiviral Agents therapeutic use MeSH
- Hepacivirus MeSH
- Hepatitis C * diagnosis epidemiology prevention & control MeSH
- Substance Abuse, Intravenous * complications drug therapy epidemiology MeSH
- Humans MeSH
- World Health Organization MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Antiviral Agents MeSH
The elimination of HCV (hepatitis C virus) infection is, according to WHO (World Health Organization), of international interest. With new diagnostic tools and treatment possibilities, one major challenge for the elimination is to involve infected patients, especially those from socially excluded subpopulations, into HCV infection-treatment programs. The key question is how to help people who inject drugs (PWID) to engage in HCV infection-treatment programs and improve communication between PWID and hepatologists or other medical professionals involved in the treatment of chronic HCV infection. Furthermore, the medical professionals have to accept the changing spectrum of patients with chronic viral hepatitis. Without close interdisciplinary cooperation, it would be extremely difficult to achieve the WHO goal of global viral hepatitis C elimination. Here, we try to encourage our colleagues as well as addictologists and social workers to play their crucial part in the viral hepatitis C eradication process. It is extremely important for the healthcare providers to be able to communicate with addicted clients, inform PWID about the latest developments in the diagnosis and HCV infection treatment, and get them motivated to engage with specialized treatment programs.
See more in PubMed
World Health Organization . Global Hepatitis Report, 2017. World Health Organization; Geneva, Switzerland: 2017.
World Health Organization . Guidelines for the Screening Care and Treatment of Persons with Chronic Hepatitis C Infection. World Health Organization; Geneva, Switzerland: 2016.
Wiessing L., Ferri M., Grady B., Kantzanou M., Sperle I., Cullen K.J., Hatzakis A., Prins M., Vickerman P., Lazarus J., et al. Hepatitis C Virus Infection Epidemiology among People Who Inject Drugs in Europe: A Systematic Review of Data for Scaling Up Treatment and Prevention. PLoS ONE. 2014;9:e103345. doi: 10.1371/journal.pone.0103345. PubMed DOI PMC
World Health Organization . Global Health Sector Strategy on Viral Hepatitis 2016–2021: Towards Ending Viral Hepatitis. World Health Organization; Geneva, Switzerland: 2016.
World Health Organization . Combating Hepatitis B and C to Reach Elimination by 2030: Advocacy Brief. World Health Organization; Geneva, Switzerland: 2016.
Yousafzai M.T., Bajis S., Alavi M., Grebely J., Dore G.J., Hajarizadeh B. Global cascade of care for chronic hepatitis C virus infection: A systematic review and meta-analysis. J. Viral Hepat. 2021;28:1340–1354. doi: 10.1111/jvh.13574. PubMed DOI
The Polaris Observatory HCV Collaborators Global prevalence and genotype distribution of hepatitis C virus infection in 2015: A modelling study. Lancet Gastroenterol. Hepatol. 2017;2:161–176. doi: 10.1016/S2468-1253(16)30181-9. PubMed DOI
Razavi H., ElKhoury A.C., Elbasha E., Estes C., Pasini K., Poynard T., Kumar R. Chronic hepatitis C virus (HCV) disease burden and cost in the United States. Hepatology. 2013;57:2164–2170. doi: 10.1002/hep.26218. PubMed DOI PMC
Zibell J.E., Igball K., Patel R.C. Increases in hepatitis C virus infection related to injection drug use among persons aged ≤30 years—Kentucky, Tennessee, Virginia, and West Virginia, 2006–2012. MMWR Morb. Mortal Wkly Rep. 2015;64:453–458. PubMed PMC
Suryaprasad A.G., White J.Z., Xu F., Eichler B.-A., Hamilton J., Patel A., Hamdounia S.B., Church D.R., Barton K., Fisher C., et al. Emerging Epidemic of Hepatitis C Virus Infections among Young Nonurban Persons Who Inject Drugs in the United States, 2006–2012. Clin. Infect. Dis. 2014;59:1411–1419. doi: 10.1093/cid/ciu643. PubMed DOI
Hajarizadeh B., Cunningham E.B., Reid H., Law M., Dore G.J., Grebely J. Direct-acting antiviral treatment for hepatitis C among people who use or inject drugs: A systematic review and meta-analysis. Lancet Gastroenterol. Hepatol. 2018;3:754–767. doi: 10.1016/S2468-1253(18)30304-2. PubMed DOI
Grebely J., Larney S., Peacock A., Colledge S., Leung J., Hickman M., Vickerman P., Blach S., Cunningham E.B., Dumchev K., et al. Global, regional, and country-level estimates of hepatitis C infection among people who have recently injected drugs. Addiction. 2019;114:150–166. doi: 10.1111/add.14393. PubMed DOI PMC
Degenhardt L., Peacock A., Colledge S., Leung J., Grebely J., Vickerman P., Stone J., Cunningham E.B., Trickey A., Dumchev K., et al. Global prevalence of injecting drug use and sociodemographic characteristics and prevalence of HIV, HBV, and HCV in people who inject drugs: A multistage systematic review. Lancet Glob. Health. 2017;5:e1192–e1207. doi: 10.1016/S2214-109X(17)30375-3. PubMed DOI PMC
Degenhardt L., Charlson F., Stanaway J., Larney S., Alexander L.T., Hickman M., Cowie B., Hall W.D., Strang J., Whiteford H., et al. Estimating the burden of disease attributable to injecting drug use as a risk factor for HIV, hepatitis C, and hepatitis B: Findings from the Global Burden of Disease Study 2013. Lancet Infect. Dis. 2016;16:1385–1398. doi: 10.1016/S1473-3099(16)30325-5. PubMed DOI
Razavi H., Robbins S., Zeuzem S., Negro F., Buti M., Duberg A.-S., Roudot-Thoraval F., Craxi A., Manns M., Marinho R.T., et al. Hepatitis C virus prevalence and level of intervention required to achieve the WHO targets for elimination in the European Union by 2030: A modelling study. Lancet Gastroenterol. Hepatol. 2017;2:325–336. doi: 10.1016/S2468-1253(17)30045-6. PubMed DOI
U.S. Food and Drug Administration In Proceedings of the Antiviral Drugs Advisory Committee Meeting; Silver Spring, MD, USA. 27–28 April 2011.
Stanaway J.D., Flaxman A.D., Naghavi M., Fitzmaurice C., Vos T., Abubakar I., Abu-Raddad L.J., Assadi R., Bhala N., Cowie B., et al. The global burden of viral hepatitis from 1990 to 2013: Findings from the Global Burden of Disease Study 2013. Lancet. 2016;388:1081–1088. doi: 10.1016/S0140-6736(16)30579-7. PubMed DOI PMC
Hickman M., De Angelis D., Vickerman P., Hutchinson S., Martin N.K. Hepatitis C virus treatment as prevention in people who inject drugs: Testing the evidence. Curr. Opin. Infect. Dis. 2015;28:576–582. doi: 10.1097/QCO.0000000000000216. PubMed DOI PMC
Zoulim F., Liang T.J., Gerbes A.L., Aghemo A., Deuffic-Burban S., Dusheiko G.M., Fried M.W., Pol S., Rockstroh J.K., A Terrault N., et al. Hepatitis C virus treatment in the real world: Optimising treatment and access to therapies. Gut. 2015;64:1824–1833. doi: 10.1136/gutjnl-2015-310421. PubMed DOI PMC
Sarrazin C. The importance of resistance to direct antiviral drugs in HCV infection in clinical practice. J. Hepatol. 2016;64:486–504. doi: 10.1016/j.jhep.2015.09.011. PubMed DOI
Ceccherini-Silberstein F., Cento V., Di Maio V.C., Perno C.F., Craxì A. Viral resistance in HCV infection. Curr. Opin. Virol. 2018;32:115–127. doi: 10.1016/j.coviro.2018.10.005. PubMed DOI
Hezode C., Reau N., Svarovskaia E.S., Doehle B.P., Shanmugam R., Dvory-Sobol H., Hedskog C., McNally J., Osinusi A., Brainard D.M., et al. Resistance analysis in patients with genotype 1–6 HCV infection treated with sofosbuvir/velpatasvir in the phase III studies. J. Hepatol. 2018;68:895–903. doi: 10.1016/j.jhep.2017.11.032. PubMed DOI
Chhatwal J., Chen Q., Ayer T., Bethea E.D., Kanwal F., Kowdley K.V., Wang X., Roberts M.S., Gordon S.C. Hepatitis C virus re-treatment in the era of direct-acting antivirals: Projections in the USA. Aliment. Pharmacol. Ther. 2018;47:1023–1031. doi: 10.1111/apt.14527. PubMed DOI PMC
Sarrazin C. Treatment failure with DAA therapy: Importance of resistance. J. Hepatol. 2021;74:1472–1482. doi: 10.1016/j.jhep.2021.03.004. PubMed DOI
Abravanel F., Métivier S., Chauveau M., Péron J.-M., Izopet J. Transmission of HCV NS5A Inhibitor–Resistant Variants Among HIV-Infected Men Who Have Sex with Men. Clin. Infect. Dis. 2016;63:1271–1272. doi: 10.1093/cid/ciw554. PubMed DOI
Centers for Disease Control and Prevention (CDC) Testing for HCV infection: An update of guidance for clinicians and laboratorians. MMWR Morb. Mortal Wkly Rep. 2013;62:362–365. PubMed PMC
Major M.E., Rehermann B., Feinstone S.M. Hepatitis C viruses. In: Fields B.N., Knipe D.M., Howley P.M., Griffin D.E., editors. Fields Virology. 4th ed. Lippincott Williams & Wilkins; Philadelphia, PA, USA: 2001. pp. 1127–1161.
Lau J.Y., Davis G.L., Prescott L.E., Maertens G., Lindsay K.L., Qian K., Mizokami M., Simmonds P. Distribution of Hepatitis C Virus Genotypes Determined by Line Probe Assay in Patients with Chronic Hepatitis C Seen at Tertiary Referral Centers in the United States. Ann. Intern. Med. 1996;124:868–876. doi: 10.7326/0003-4819-124-10-199605150-00002. PubMed DOI
Li J.-S., Tong S.-P., Vitvitski L., Trépo C. Single-step nested polymerase chain reaction for detection of different genotypes of hepatitis C virus. J. Med. Virol. 1995;45:151–155. doi: 10.1002/jmv.1890450207. PubMed DOI
Stuyver L., Rossau R., Wyseur A., Duhamel M., VanderBorght B., Van Heuverswyn H., Maertens G. Typing of hepatitis C virus isolates and characterization of new subtypes using a line probe assay. J. Gen. Virol. 1993;74:1093–1102. doi: 10.1099/0022-1317-74-6-1093. PubMed DOI
HCV Guidance HCV Guidance: Recommendations for Testing, Managing, and Treating Hepatitis C. AASLD. [(accessed on 16 March 2021)]. Available online: https://www.hcvguidelines.org/unique-populations/acute-infection.
Lim J.K., Flamm S.L., Singh S., Falck-Ytter Y.T., Gerson L., Hirano I., Nguyen G.C., Rubenstein J.H., Smalley W.E., Stollman N., et al. American Gastroenterological Association Institute Guideline on the Role of Elastography in the Evaluation of Liver Fibrosis. Gastroenterology. 2017;152:1536–1543. doi: 10.1053/j.gastro.2017.03.017. PubMed DOI
Flisiak R., Jaroszewicz J., Parfieniuk-Kowerda A. Emerging treatments for hepatitis C. Expert Opin. Emerg. Drugs. 2013;18:461–475. doi: 10.1517/14728214.2013.847089. PubMed DOI
Martinot-Peignoux M., Stern C., Maylin S., Ripault M.-P., Boyer N., LeClere L., Castelnau C., Giuily N., El Ray A., Cardoso A.-C., et al. Twelve weeks posttreatment follow-up is as relevant as 24 weeks to determine the sustained virologic response in patients with hepatitis C virus receiving pegylated interferon and ribavirin. Hepatology. 2010;51:1122–1126. doi: 10.1002/hep.23444. PubMed DOI
Maylin S., Martinot–Peignoux M., Moucari R., Boyer N., Ripault M., Cazals–Hatem D., Giuily N., Castelnau C., Cardoso A.C., Asselah T., et al. Eradication of Hepatitis C Virus in Patients Successfully Treated for Chronic Hepatitis C. Gastroenterology. 2008;135:821–829. doi: 10.1053/j.gastro.2008.05.044. PubMed DOI
Simmons B., Saleem J., Hill A., Riley R.D., Cooke G.S. Risk of Late Relapse or Reinfection with Hepatitis C Virus After Achieving a Sustained Virological Response: A Systematic Review and Meta-analysis. Clin. Infect. Dis. 2016;62:683–694. doi: 10.1093/cid/civ948. PubMed DOI PMC
Afdhal N., Everson G.T., Calleja J.L., Mccaughan G., Bosch J., Brainard D.M., McHutchison J.G., De-Oertel S., An D., Charlton M., et al. Effect of viral suppression on hepatic venous pressure gradient in hepatitis C with cirrhosis and portal hypertension. J. Viral Hepat. 2017;24:823–831. doi: 10.1111/jvh.12706. PubMed DOI
Kim R.W., Mannalithara A., Lee H., Osinusi A., Schall R.E.A., Brainard D.M. Survival benefit of direct acting antiviral therapy in patients with decompensated cirrhosis. Hepatology. 2017;66:LB27. doi: 10.1016/S0168-8278(18)30387-8. DOI
European Association for the Study of the Liver EASL Recommendations on Treatment of Hepatitis C 2018. J. Hepatol. 2018;69:461–511. doi: 10.1016/j.jhep.2018.03.026. PubMed DOI
Pawlotsky J.M., Negro F., Aghemo A., Berenguer M., Dalgard O., Dusheiko G., Marra F., Puoti M., Wedemeyer H., European Association for the Study of the Liver EASL recommendations on treatment of hepatitis C: Final update of the series. J. Hepatol. 2020;73:1170–1218. doi: 10.1016/j.jhep.2020.08.018. PubMed DOI