Optimized expression of alternative oxidase
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Comment
PubMed
35577968
PubMed Central
PMC9750857
DOI
10.1038/s41434-022-00340-7
PII: 10.1038/s41434-022-00340-7
Knihovny.cz E-resources
- MeSH
- Mitochondrial Proteins metabolism MeSH
- Oxidoreductases * biosynthesis genetics MeSH
- RNA * MeSH
- Plant Proteins genetics metabolism MeSH
- Mammals genetics metabolism MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Comment MeSH
- Names of Substances
- alternative oxidase MeSH Browser
- Mitochondrial Proteins MeSH
- Oxidoreductases * MeSH
- RNA * MeSH
- Plant Proteins MeSH
Institute of Biotechnology Czech Academy of Sciences Prague West Czech Republic
School of Pharmacy and Medical Science Griffith University Southport QLD Australia
See more in PubMed
Giordano L, Aneja MK, Sommer N, Alebrahimdehkordi N, Seraji A, Weissmann N, et al. Alternative oxidase encoded by sequence-optimized and chemically-modified RNA transfected into mammalian cells is catalytically active. Gene Ther. 2021. 10.1038/s41434-021-00235-z. PubMed PMC
Dassa EP, Dufour E, Goncalves S, Paupe V, Hakkaart GAJ, Jacobs HT, et al. Expression of the alternative oxidase complements cytochrome c oxidase deficiency in human cells. EMBO Mol Med. 2009;1:30–36. doi: 10.1002/emmm.200900001. PubMed DOI PMC
Fernandez-Ayala DJM, Sanz A, Vartiainen S, Kemppainen KK, Babusiak M, Mustalahti E, et al. Expression of the Ciona intestinalis alternative oxidase (AOX) in Drosophila complements defects in mitochondrial oxidative phosphorylation. Cell Metab. 2009;9:449–60. doi: 10.1016/j.cmet.2009.03.004. PubMed DOI
Hakkaart GA, Dassa EP, Jacobs HT, Rustin P. Allotopic expression of a mitochondrial alternative oxidase confers cyanide resistance to human cell respiration. EMBO Rep. 2006;7:341–5. doi: 10.1038/sj.embor.7400601. PubMed DOI PMC
Rajendran J, Purhonen J, Tegelberg S, Smolander OP, Mörgelin M, Rozman J, et al. Alternative oxidase-mediated respiration prevents lethal mitochondrial cardiomyopathy. EMBO Mol Med. 2019;11:e9456. doi: 10.15252/emmm.201809456. PubMed DOI PMC
Bajzikova M, Kovarova J, Coelho AR, Boukalova S, Oh S, Rohlenova K, et al. Reactivation of dihydroorotate dehydrogenase by respiration restores tumor growth of mitochondrial DNA-depleted cancer cells. Cell Metab. 2019;29:399–416. doi: 10.1016/j.cmet.2018.10.014. PubMed DOI PMC
Martinez-Reyes I, Cardona LR, Kong H, Vasan K, McElroy GS, Werner M, et al. Mitochondrial ubiquinol oxidation is necessary for tumour growth. Nature. 2020;585:288–92. doi: 10.1038/s41586-020-2475-6. PubMed DOI PMC
