Complications of Autologous Stem Cell Transplantation in Multiple Myeloma: Results from the CALM Study
Status PubMed-not-MEDLINE Jazyk angličtina Země Švýcarsko Médium electronic
Typ dokumentu časopisecké články
PubMed
35743620
PubMed Central
PMC9225651
DOI
10.3390/jcm11123541
PII: jcm11123541
Knihovny.cz E-zdroje
- Klíčová slova
- autologous stem cell transplantation in multiple myeloma, complications, multiple myeloma,
- Publikační typ
- časopisecké články MeSH
Background: The main goal of this post hoc analysis of the Collaboration to Collect Autologous Transplant Outcomes in Lymphoma and Myeloma (CALM) study was to evaluate the rate of short- and long-term infectious and non-infectious complications occurring after ASCT in patients with multiple myeloma (MM). Methods: The analysis included all patients with MM from the CALM study who underwent ≥1 ASCT. The primary endpoint of the analysis was to determine the rate of infectious and non-infectious complications after ASCT and to compare them in three time periods: 0−100 days, 101 days−1 year, and >1 year after the first transplant. Results: The analysis included a total of 3552 patients followed up for a median of 56.7 months (range 0.4−108.1). Complication rates decreased with the time from ASCT with 24.85 cases per 100 patient-years from day 0 to 100 days after the transplant, and <2.31 cases per 100 patient-years from the 101st day. At 100 days after ASC T, 45.7% of patients had complications, with infectious events being twice as frequent as non-infectious complications. Bacterial infections (6.5 cases per 100 patient-years, 95% CI: 6.1−7.0) and gastrointestinal complications (4.7 cases per 100 patient-years, 95% CI: 4.3−5.1) were the most common early events. The pattern of complications changed with time from ASCT. The presence of complications after ASCT was not associated with overall survival. Conclusions: Our data provide a solid basis for comparing ASCT-related complications to those caused by emerging treatments in multiple myeloma, such as CAR T-cell therapy and other immunotherapies.
Belfast City Hospital Belfast BT9 7AB UK
Centre de Recherche Saint Antoine Sorbonne Université INSERM UMR_S 938 75013 Paris France
Charité Universitätsmedizin Berlin 10771 Berlin Germany
CHU de Lille 59000 Lille France
CHU Nantes 44000 Nantes France
Dél Pesti Centrumkórház 1097 Budapest Hungary
Department of Haemato Oncology St Bartholomew's Hospital Barts Health NHS Trust London EC1A 7BE UK
Department of Hematology University Hospitals Leuven 3000 Leuven Belgium
Department of Internal Medicine School of Medicine University of Zagreb 10000 Zagreb Croatia
Department of Pediatric Hematology and Oncology Collegium Medicum UMK 85 067 Bydgoszcz Poland
Division of Hematology Department of Medicine Huddinge Karolinska Institute 171 77 Stockholm Sweden
Division of Hematology SST Papa Giovanni XXIII 24127 Bergamo Italy
Division of Infectious Diseases Department of Health Sciences University of Genoa 16121 Genoa Italy
Division of Infectious Diseases IRC CS Ospedale Policlinico San Martino 16132 Genoa Italy
EBMT Data Office Leiden 2333 AA Leiden The Netherlands
George Papanicolaou General Hospital 57010 Thessaloniki Greece
Heinrich Heine Universitaet 40225 Duesseldorf Germany
Hope Directorate D08 NHY1 Dublin Ireland
Hôpital St Louis 75010 Paris France
Hospital Santa Creu i Sant Pau 08001 Barcelona Spain
Imperial College London SW7 2BX UK
Institut Paoli Calmettes 13009 Marseille France
Nottingham University Nottingham NG7 2QL UK
Radboud University Medical Centre Department of Hematology 6525 GA Nijmegen The Netherlands
Skanes University Hospital 23262 Lund Sweden
Tor Vergata University 00133 Rome Italy
University Hospital 12808 Prague Czech Republic
University Hospital Brno 62500 Brno Czech Republic
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