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Autor
Aljurf, Mahmoud 1 Anagnostopoulos, Achilles 1 Apperley, Jane 1 Basak, Grzegorz W 1 Blaise, Didier 1 Browne, Paul 1 Duarte, Rafael F 1 Garderet, Laurent 1 Iacobelli, Simona 1 Jantunen, Esa 1 Kobbe, Guido 1 Koenecke, Christian 1 Koster, Linda 1 Kröger, Nicolaus 1 Lenhoff, Stig 1 Ljungman, Per 1 Mayer, Jiri 1 Mikulska, Malgorzata 1 Moiseev, Ivan 1 Montoto, Silvia 1
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Pracoviště
Belfast City Hospital Belfast BT9 7AB UK 1 CHU Nantes 44000 Nantes France 1 CHU de Lille 59000 Lille France 1 Centre de Recherche Saint Antoine Sor... 1 Charité Universitätsmedizin Berlin 10... 1 Clinical Research Institute Helsinki ... 1 Comprehensive Cancer Center Departmen... 1 Department of Cellular Therapy and Al... 1 Department of Haemato Oncology St Bar... 1 Department of Hematology Hemostasis O... 1 Department of Hematology Transplantat... 1 Department of Hematology University H... 1 Department of Internal Medicine 5 Div... 1 Department of Internal Medicine Schoo... 1 Department of Medicine University of ... 1 Department of Pediatric Hematology an... 1 Department of Public Health and Prima... 1 Division of Hematology Department of ... 1 Division of Hematology SST Papa Giova... 1 Division of Infectious Diseases Depar... 1
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Autor
Aljurf, Mahmoud 1 Anagnostopoulos, Achilles 1 Apperley, Jane 1 Basak, Grzegorz W 1 Blaise, Didier 1 Browne, Paul 1 Duarte, Rafael F 1 Garderet, Laurent 1 Iacobelli, Simona 1 Jantunen, Esa 1 Kobbe, Guido 1 Koenecke, Christian 1 Koster, Linda 1 Kröger, Nicolaus 1 Lenhoff, Stig 1 Ljungman, Per 1 Mayer, Jiri 1 Mikulska, Malgorzata 1 Moiseev, Ivan 1 Montoto, Silvia 1
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Pracoviště
Belfast City Hospital Belfast BT9 7AB UK 1 CHU Nantes 44000 Nantes France 1 CHU de Lille 59000 Lille France 1 Centre de Recherche Saint Antoine Sor... 1 Charité Universitätsmedizin Berlin 10... 1 Clinical Research Institute Helsinki ... 1 Comprehensive Cancer Center Departmen... 1 Department of Cellular Therapy and Al... 1 Department of Haemato Oncology St Bar... 1 Department of Hematology Hemostasis O... 1 Department of Hematology Transplantat... 1 Department of Hematology University H... 1 Department of Internal Medicine 5 Div... 1 Department of Internal Medicine Schoo... 1 Department of Medicine University of ... 1 Department of Pediatric Hematology an... 1 Department of Public Health and Prima... 1 Division of Hematology Department of ... 1 Division of Hematology SST Papa Giova... 1 Division of Infectious Diseases Depar... 1
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- Waszczuk-Gajda, Anna
- Penack, Olaf
- Sbianchi, Giulia
- Koster, Linda
- Blaise, Didier
- Reményi, Péter
- Russell, Nigel
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Ljungman, Per
Autor Autorita ORCID Department of Cellular Therapy and Allogeneic Stem Cell Transplantation, Karolinska Comprehensive Cancer Center, Karolinska University Hospital Huddinge, 17177 Stockholm, Sweden Division of Hematology, Department of Medicine Huddinge, Karolinska Institute, 171 77 Stockholm, Sweden
- Trneny, Marek
- Mayer, Jiri
Free Medical Journals od 2012
PubMed Central od 2012
Europe PubMed Central od 2012
ProQuest Central od 2019-01-01
Open Access Digital Library od 2012-01-01
Open Access Digital Library od 2012-01-01
Health & Medicine (ProQuest) od 2019-01-01
ROAD: Directory of Open Access Scholarly Resources od 2012
PubMed
35743620
DOI
10.3390/jcm11123541
Knihovny.cz E-zdroje
BACKGROUND: The main goal of this post hoc analysis of the Collaboration to Collect Autologous Transplant Outcomes in Lymphoma and Myeloma (CALM) study was to evaluate the rate of short- and long-term infectious and non-infectious complications occurring after ASCT in patients with multiple myeloma (MM). METHODS: The analysis included all patients with MM from the CALM study who underwent ≥1 ASCT. The primary endpoint of the analysis was to determine the rate of infectious and non-infectious complications after ASCT and to compare them in three time periods: 0-100 days, 101 days-1 year, and >1 year after the first transplant. RESULTS: The analysis included a total of 3552 patients followed up for a median of 56.7 months (range 0.4-108.1). Complication rates decreased with the time from ASCT with 24.85 cases per 100 patient-years from day 0 to 100 days after the transplant, and <2.31 cases per 100 patient-years from the 101st day. At 100 days after ASC T, 45.7% of patients had complications, with infectious events being twice as frequent as non-infectious complications. Bacterial infections (6.5 cases per 100 patient-years, 95% CI: 6.1-7.0) and gastrointestinal complications (4.7 cases per 100 patient-years, 95% CI: 4.3-5.1) were the most common early events. The pattern of complications changed with time from ASCT. The presence of complications after ASCT was not associated with overall survival. CONCLUSIONS: Our data provide a solid basis for comparing ASCT-related complications to those caused by emerging treatments in multiple myeloma, such as CAR T-cell therapy and other immunotherapies.
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