Aflatoxins are toxic secondary metabolites produced by Aspergillus fungi. The most toxic among them is Aflatoxin B1 (AFB1) which is known to have genotoxic, immunotoxic, teratogenic, carcinogenic, and mutagenic toxic effects (amongst others). The mechanisms responsible for its toxicity include the induction of oxidative stress, cytotoxicity, and DNAdamage. Studies have found that natural anti-oxidants can reduce the damage that AFB1 inflicts on the body by alleviating oxidative stress and inhibiting the biotransformation of AFB1. Therefore, this review outlines the latest progress in research on the use of natural anti-oxidants as antidotes to aflatoxin poisoning and their detoxification mechanisms. It also considers the problems that may possibly arise from their use and their application prospects. Our aim is to provide a useful reference for the prevention and treatment of AFB1 poisoning.

Department of Chemistry Faculty of Science University of Hradec Kralove Hradec Kralove 50003 Czech Republic

Department of Chemistry Faculty of Science University of Hradec Kralove Hradec Kralove 50003 Czech Republic; Biomedical Research Center University Hospital Hradec Kralove Hradec Kralove 50003 Czech Republic

Department of Chemistry Faculty of Science University of Hradec Kralove Hradec Kralove 50003 Czech Republic; MOE Joint International Research Laboratory of Animal Health and Food Safety College of Veterinary Medicine Nanjing Agricultural University Nanjing 210095 China

Key Laboratory of Zoonosis of Liaoning Province College of Animal Science and Veterinary Medicine Shenyang Agricultural University Shenyang 110866 China

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