AIMS: The study analysed post-acute COVID-19 symptoms and the pulmonary function test (PFT) results in patients surviving the native strain of the virus. METHODS: The study was prospective; the inclusion criteria were positive PCR test for SARS-CoV-2 and age 18-100. Exclusion criteria were active respiratory infection, known or suspicious pre-existing pulmonary disease, cardiac failure, recent or acute pulmonary embolism, anaemia, and neuromuscular diseases. The recruitment period was 1st March 2020 - 25th December 2020. The initial examination was performed 4-12 weeks after the disease onset. All subjects underwent physical examination, anamnesis, chest x-ray and PFT. RESULTS: The study involved 785 subjects (345 male) mean age 53.8 (SD 14.6). The disease severity groups were: mild (G1), moderate (G2) and severe/critical (G3). Anosmia was present in the acute disease phase in 45.2% of G1 patients, but only in 4.5% of G3 patients. Dyspnoea occurred frequently in more severe groups (40%, 51.8% and 63.7% for G1, G2 and G3 respectively), while cough and fatigue showed no relationship to disease severity. Females were more likely to experience persistent symptoms. PFT results were significantly decreased in more severe groups compared to the mild COVID-19 patients, diffusing capacity was 86.3%, 79% and 68% of predicted values in G1, G2 and G3 respectively. CONCLUSION: Anosmia during the acute phase was associated with mild disease, persisting dyspnoea was more frequent after more severe COVID-19. Females tended to have persisting symptoms in post-acute phase more frequently. PFT results showed decrease with disease severity.

Department of Respiratory Diseases and Tuberculosis University Hospital and Faculty of Medicine and Dentistry Pavol Jozef Safarik University Kosice Slovak Republic

Department of Respiratory Diseases and Tuberculosis University Hospital Brno and Faculty of Medicine and Dentistry Masaryk University Brno Czech Republic

Department of Respiratory Diseases and Tuberculosis University Hospital Olomouc and Faculty of Medicine and Dentistry Palacky University Olomouc Olomouc Czech Republic

Department of Telecommunications University of Technology Brno Czech Republic

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Coronavirus Disease 2019 (COVID-19) Treatment Guidelines. Bethesda (MD): National Institutes of Health (US); 2021. PMID: 34003615. [cited 2022 May 15] Available from: https://www.covid19treatmentguidelines.nih.gov.

Purja S, Shin H, Lee JY, Kim E. Is loss of smell an early predictor of COVID-19 severity: a systematic review and meta-analysis. Arch Pharm Res 2021;44(7):725-40. doi: 10.1007/s12272-021-01344-4 PubMed DOI

Carfì A, Bernabei R, Landi F; Gemelli Against COVID-19 Post-Acute Care Study Group. Persistent Symptoms in Patients After Acute COVID-19. JAMA 2020;324(6):603-5. doi: 10.1001/jama.2020.12603 PubMed DOI

Halpin SJ, McIvor C, Whyatt G, Adams A, Harvey O, McLean L, Walshaw C, Kemp S, Corrado J, Singh R, Collins T, O'Connor RJ, Sivan M. Post-discharge symptoms and rehabilitation needs in survivors of COVID-19 infection: A cross-sectional evaluation. J Med Virol 2021;93(2):1013-22. doi: 10.1002/jmv.26368 PubMed DOI

Wang X, Xu H, Jiang H, Wang L, Lu C, Wei X, Liu J, Xu S. Clinical features and outcomes of discharged coronavirus disease 2019 patients: a prospective cohort study. QJM 2020;113(9):657-65. doi: 10.1093/qjmed/hcaa178 PubMed DOI

Lopez-Leon, Wegman-Ostrosky T, Perelman C, Sepulveda R, Rebolledo PA, Cuapio A, Villapol S. More than 50 Long-term effects of COVID-19: a systematic review and meta-analysis. medRxiv [Preprint]. 2021 Jan 30:2021.01.27.21250617. doi: 10.1101/2021.01.27.21250617. Update in: Sci Rep 2021;11(1):16144. doi: 10.1101/2021.01.27.21250617 PubMed DOI

Cares-Marambio K, Montenegro-Jiménez Y, Torres-Castro R, Vera-Uribe R, Torralba Y, Alsina-Restoy X, Vasconcello-Castillo L, Vilaró J. Prevalence of potential respiratory symptoms in survivors of hospital admission after coronavirus disease 2019 (COVID-19): a systematic review and meta-analysis. Chronic Respir Dis 2021;18:14799731211002240. doi: 10.1177/14799731211002240 PubMed DOI

Fernández-de-Las-Peñas C, Guijarro C, Plaza-Canteli S, Hernández-Barrera V, Torres-Macho J. Prevalence of Post-COVID-19 Cough One Year After SARS-CoV-2 Infection: A Multicenter Study. Lung 2021;199(3):249-53. doi: 10.1007/s00408-021-00450-w PubMed DOI

Moreno-Pérez O, Merino E, Leon-Ramirez JM, Andres M, Ramos JM, Arenas-Jiménez J, Asensio S, Sanchez R, Ruiz-Torregrosa P, Galan I, Scholz A, Amo A, González-delaAleja P, Boix V, Gil J; COVID19-ALC research group. Post-acute COVID-19 syndrome. Incidence and risk factors: A Mediterranean cohort study. J Infect 2021;82(3):378-83. doi: 10.1016/j.jinf.2021.01.004 PubMed DOI

Torres-Castro R, Vasconcello-Castillo L, Alsina-Restoy X, Solis-Navarro L, Burgos F, Puppo H, Vilaró J. Respiratory function in patients post-infection by COVID-19: a systematic review and meta-analysis. Pulmonology 2021;27(4):328-37.doi: 10.1016/j.pulmoe.2020.10.013 PubMed DOI

Huang Y, Tan C, Wu J, Chen M, Wang Z, Luo L, Zhou X, Liu X, Huang X, Yuan S, Chen C, Gao F, Huang J, Shan H, Liu J. Impact of coronavirus disease 2019 on pulmonary function in early convalescence phase. Respir Res 2020;21(1):163. doi: 10.1186/s12931-020-01429-6 PubMed DOI

Frija-Masson J, Debray MP, Gilbert M, Lescure FX, Travert F, Borie R, Khalil A, Crestani B, d'Ortho MP, Bancal C. Functional characteristics of patients with SARS-CoV-2 pneumonia at 30 days post-infection. Eur Respir J 2020;56(2):2001754. doi: 10.1183/13993003.01754-2020 PubMed DOI

Zhao Y, Yang C, An X, Xiong Y, Shang Y, He J, Qiu Y, Zhang N, Huang L, Jia J, Xu Q, Zhang L, Zhao J, Pei G, Luo H, Wang J, Li Q, Gao Y, Xu A. Follow-up study on COVID-19 survivors one year after discharge from hospital. Int J Infect Dis 2021;112:173-182. doi: 10.1016/j.ijid.2021.09.017 PubMed DOI

Graham BL, Steenbruggen I, Miller MR, Barjaktarevic IZ, Cooper BG, Hall GL, Hallstrand TS, Kaminsky DA, McCarthy K, McCormack MC, Oropez CE, Rosenfeld M, Stanojevic S, Swanney MP, Thompson BR. Standardization of Spirometry 2019 Update. An Official American Thoracic Society and European Respiratory Society Technical Statement. Am J Respir Crit Care Med 2019;200(8):70-88. doi: 10.1164/rccm.201908-1590ST PubMed DOI

Dalpiaz G, Cancellieri A. Alveolar Pattern. In: Dalpiaz, G., Cancellieri, A. (eds) Atlas of Diffuse Lung Diseases. Springer, Cham. 2017. https://doi.org/10.1007/978-3-319-42752-2_9. DOI

Stanojevic S, Kaminsky DA, Miller M, Thompson B, Aliverti A, Barjaktarevic I, Cooper BG, Culver B, Derom E, Hall GL, Hallstrand TS, Leuppi JD, MacIntyre N, McCormack M, Rosenfeld M, Swenson ER. ERS/ATS technical standard on interpretive strategies for routine lung function tests. Eur Respir J 2021:2101499. doi: 10.1183/13993003.01499-2021 PubMed DOI

Genzor S, Sova M, Mizera J, Jakubec P. COVID-19 related olfactory impairment - diagnostics, significance, and treatment. Cesk Slov Neurol N 2021;84(4):347-52. doi: 10.48095/cccsnn2021347 DOI

Mahil SK, Dand N, Mason KJ, Yiu ZZN, Tsakok T, Meynell F, Smith CH; PsoProtect study group. Factors associated with adverse COVID-19 outcomes in patients with psoriasis-insights from a global registry-based study. J Allergy Clin Immunol 2021;147(1):60-71. doi: 10.1016/j.jaci.2020.10.007 PubMed DOI

González J, Benítez ID, Carmona P, Santisteve S, Monge A, Moncusí-Moix A, Gort-Paniello C, Pinilla L, Carratalá A, Zuil M, Ferrer R, Ceccato A, Fernández L, Motos A, Riera J, Menéndez R, Garcia-Gasulla D, Peñuelas O, Bermejo-Martin JF, Labarca G, Caballero J, Torres G, de Gonzalo-Calvo D, Torres A, Barbé F; CIBERESUCICOVID Project (COV20/00110, ISCIII). Pulmonary Function and Radiologic Features in Survivors of Critical COVID-19: A 3-Month Prospective Cohort Chest 2021;160(1):187-98. doi: 10.1016/j.chest.2021.02.062 PubMed DOI

Huang C, Huang L, Wang Y, Li X, Ren L, Gu X, Kang L, Guo L, Liu M, Zhou X, Luo J, Huang Z, Tu S, Zhao Y, Chen L, Xu D, Li Y, Li C, Peng L, Li Y, Xie W, Cui D, Shang L, Fan G, Xu J, Wang G, Wang Y, Zhong J, Wang C, Wang J, Zhang D, Cao B. 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. Lancet 2021;397(10270):220-32. doi: 10.1016/S0140-6736(20)32656-8 PubMed DOI

Tirelli U, Franzini M, Valdenassi L, Pisconti S, Taibi R, Torrisi C, Pandolfi S, Chirumbolo S. Fatigue in post-acute sequelae of SARS-CoV2 (PASC) treated with oxygen-ozone autohemotherapy - preliminary results on 100 patients. Eur Rev Med Pharmacol Sci 2021;25(18):5871-75. doi: 10.26355/eurrev_202109_26809 PubMed DOI

Banić M, Janković Makek M, Samaržija M, Muršić D, Boras Z, Trkeš V, Baričević D, Koršić M, Basara L, Jalušić Glunčić T, Vukić Dugac A. Risk factors and severity of functional impairment in long COVID: a single-center experience in Croatia. Croat Med J 2022;63(1):27-35. doi: 10.3325/cmj.2022.27 PubMed DOI

Sudre CH, Murray B, Varsavsky T, Graham MS, Penfold RS, Bowyer RC, Pujol JC, Klaser K, Antonelli M, Canas LS, Molteni E, Modat M, Jorge Cardoso M, May A, Ganesh S, Davies R, Nguyen LH, Drew DA, Astley CM, Joshi AD, Merino J, Tsereteli N, Fall T, Gomez MF, Duncan EL, Menni C, Williams FMK, Franks PW, Chan AT, Wolf J, Ourselin S, Spector T, Steves CJ. Attributes and predictors of long COVID. Nat Med 2021;27(4):626-31. doi: 10.1038/s41591-021-01292-y PubMed DOI

Taquet M, Dercon Q, Luciano S, Geddes JR, Husain M, Harrison PJ. Incidence, co-occurrence, and evolution of long-COVID features: A 6-month retrospective cohort study of 273,618 survivors of COVID-19. Kretzschmar MEE, editor. PLOS Med 2021;18(9):e1003773. doi: 10.1371/journal.pmed.1003773 PubMed DOI

Skala M, Svoboda M, Kopecky M, Kocova E, Hyrsl M, Homolac M, Chrobok V, Bostik P, Fajfr M, Prasil P, Plisek S, Sleha R, Koblizek V. Heterogeneity of post-COVID impairment: interim analysis of a prospective study from Czechia. Virol J 2021;18(1):73. doi: 10.1186/s12985-021-01546-8 PubMed DOI

Long-Term Follow-Up of Patients Needing Extracorporeal Membrane Oxygenation Following a Critical Course of COVID-19

Post-COVID Syndrome and Cardiorespiratory Fitness-26-Month Experience of Single Center