Obesity is a serious metabolic disease that significantly increases cardiovascular risks and other health complications. Sarcopenia is an independent risk factor for morbidity and mortality in patients suffering from obesity that increases the health risks and is associated with cardiac, respiratory and other diseases. Bariatric and metabolic surgery (BMS) leads to significant changes in body composition. Our pilot study showed that bariatric patients are at risk of sarcopenia after BMS. This finding resulted in a hypothesis that an exercise plan in the experimental group will lead to postural stabilization and a lower decline in muscle homotopy, further leading to a greater reduction in fat mass and a positive effect of exercise on skeletal muscle volume and strength and endocrine-metabolic function. The aim of the present study is to determine the effect of programmed aerobic and strength training on muscle function, volume, and morphology in patients after BMS. The study is a single-center, randomized clinical trial after sleeve gastrectomy focused on muscle tissue. The experimental group will perform targeted physical activity once a week for 12 months and the training plan will include anaerobic and aerobic components. Magnetic resonance imaging of skeletal muscles will be correlated with the values of densitometry examination and changes in body composition, certain blood parameters of myokines, biomechanical analysis of movement abnormalities, and behavioral and dietary counseling. This study will address the research questions about the effect of programmed training on muscle tissue and muscular functions after BMS.

Department of Cybernetics and Biomedical Engineering Faculty of Electrical Engineering and Computer Science VSB Technical University of Ostrava Ostrava Czech Republic

Department of Physiology and Pathophysiology Medical Faculty University of Ostrava Ostrava Czech Republic

Department of Physiology Medical Faculty Masaryk University Brno Czech Republic; Vascular and miniinvasive surgery center Hospital AGEL Trinec Podlesi Trinec Czech Republic

Department of surgery Center of Bariatric Medicine Hospital AGEL Ostrava Vitkovice Ostrava Czech Republic; Department of surgical disciplines Medical Faculty University of Ostrava Ostrava Czech Republic

Human Movement Diagnostic Center University of Ostrava Ostrava Czech Republic

Institute of Laboratory Medicine Medical Faculty University of Ostrava Ostrava Czech Republic

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