Thirteenth Annual ENBDC Workshop: Methods in Mammary Gland Biology and Breast Cancer
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
36242657
PubMed Central
PMC9568960
DOI
10.1007/s10911-022-09526-6
PII: 10.1007/s10911-022-09526-6
Knihovny.cz E-zdroje
- Klíčová slova
- Breast cancer, Breast development, Ductal carcinoma in situ, In vivo live imaging, Lactation, Lobular breast cancer, Mammary gland biology, Organoids, Patient-derived xenografts, Resistance to endocrine therapy,
- MeSH
- biologie MeSH
- COVID-19 * MeSH
- lidé MeSH
- mléčné žlázy lidské * metabolismus MeSH
- mléčné žlázy zvířat metabolismus MeSH
- myši MeSH
- nádory prsu * genetika metabolismus MeSH
- pandemie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
The thirteenth annual workshop of the European Network for Breast Development and Cancer (ENBDC) Laboratories Annual Workshop took place on the 28-30 April 2022 in Weggis, Switzerland and focused on methods in mammary gland biology and breast cancer. Sixty scientists participated in the ENBDC annual workshop which had not been held in person since 2019 due to the global COVID-19 pandemic. Topics spanned the mammary gland biology field, ranging from lactation biology and embryonic development, single cell sequencing of the human breast, and stunning cutting-edge imaging of the mouse mammary gland and human breast as well as breast cancer research topics including invasive progression of the pre-invasive DCIS stage, metabolic determinants of endocrine therapy resistance, models for lobular breast cancer, and how mutational landscapes of normal breast during age and pregnancy determine cancer risk. The latest findings from participating researchers were presented through oral presentations and poster sessions and included plenty of unpublished work.
Department of Biomedicine University of Basel University Hospital Basel Basel Switzerland
Department of Pharmacology University of Cambridge Cambridge UK
Sorbonne Université Collège Doctoral F 75005 Paris France
The Breast Cancer Now Toby Robins Research Centre The Institute of Cancer Research London UK
Zobrazit více v PubMed
Charifou E, Traustadottir GA, Bentires-Alj M, Howard B, Van Keymeulen A. Twelfth Annual ENBDC Workshop: Methods in Mammary Gland Biology and Breast Cancer. J Mammary Gland Biol Neoplasia. 2021;26:221–6. doi: 10.1007/s10911-021-09498-z. PubMed DOI PMC
Casasent AK, et al. Multiclonal Invasion in Breast Tumors Identified by Topographic Single Cell Sequencing. Cell. 2018;172:205–17 e212. doi: 10.1016/j.cell.2017.12.007. PubMed DOI PMC
Allen MD, et al. Altered microenvironment promotes progression of preinvasive breast cancer: myoepithelial expression of alphavbeta6 integrin in DCIS identifies high-risk patients and predicts recurrence. Clin Cancer Res. 2014;20:344–57. doi: 10.1158/1078-0432.CCR-13-1504. PubMed DOI
B Cereser et al., Mutational landscapes of normal breast during age and pregnancy determine cancer risk. bioRxiv, (2020).
Hughes CS, Postovit LM, Lajoie GA. Matrigel: a complex protein mixture required for optimal growth of cell culture. Proteomics. 2010;10:1886–90. doi: 10.1002/pmic.200900758. PubMed DOI
Luisier R, Girgin M, Lutolf MP, Ranga A. Mammary epithelial morphogenesis in 3D combinatorial microenvironments. Sci Rep. 2020;10:21635. doi: 10.1038/s41598-020-78432-w. PubMed DOI PMC
Abdel Fattah AR, et al. Actuation enhances patterning in human neural tube organoids. Nat Commun. 2021;12:3192. doi: 10.1038/s41467-021-22952-0. PubMed DOI PMC
Abdel Fattah AR, Kolaitis N, Van Daele K, Rustandi AG, Ranga A. Local actuation of organoids by magnetic nanoparticles. bioRxiv, (2022).
Bacci M, et al. miR-155 Drives Metabolic Reprogramming of ER + Breast Cancer Cells Following Long-Term Estrogen Deprivation and Predicts Clinical Response to Aromatase Inhibitors. Cancer Res. 2016;76:1615–26. doi: 10.1158/0008-5472.CAN-15-2038. PubMed DOI
Bacci M, Lorito N, Smiriglia A, Morandi A. Fat and Furious: Lipid Metabolism in Antitumoral Therapy Response and Resistance. Trends Cancer. 2021;7:198–213. doi: 10.1016/j.trecan.2020.10.004. PubMed DOI
Hannezo E, et al. A Unifying Theory of Branching Morphogenesis. Cell. 2017;171:242–55 e227. doi: 10.1016/j.cell.2017.08.026. PubMed DOI PMC
Hany D, Vafeiadou V, Picard D. CRISPR/Cas9 screen reveals a role of purine synthesis for estrogen receptor a activity and tamoxifen resistance of breast cancer cells. bioRxiv, (2022). PubMed PMC
Fiche M, et al. Intraductal patient-derived xenografts of estrogen receptor alpha-positive breast cancer recapitulate the histopathological spectrum and metastatic potential of human lesions. J Pathol. 2019;247:287–92. doi: 10.1002/path.5200. PubMed DOI PMC
Sflomos G, et al. Intraductal xenografts show lobular carcinoma cells rely on their own extracellular matrix and LOXL1. EMBO Mol Med. 2021;13:e13180. doi: 10.15252/emmm.202013180. PubMed DOI PMC
Annunziato S, et al. Comparative oncogenomics identifies combinations of driver genes and drug targets in BRCA1-mutated breast cancer. Nat Commun. 2019;10:397. doi: 10.1038/s41467-019-08301-2. PubMed DOI PMC
Mourao L, Ciwinska M, van Rheenen J, Scheele C. Longitudinal Intravital Microscopy using a Mammary Imaging Window with Replaceable Lid. JoVE, e63326 (2022). PubMed
D Zimmerli et al., MYC promotes immune-suppression in TNBC via inhibition of IFN signaling. bioRxiv, (2021).
Stevenson AJ, et al. Multiscale imaging of basal cell dynamics in the functionally mature mammary gland. Proc Natl Acad Sci U S A. 2020;117:26822–32. doi: 10.1073/pnas.2016905117. PubMed DOI PMC
Dos Santos CO, Dolzhenko E, Hodges E, Smith AD, Hannon GJ. An epigenetic memory of pregnancy in the mouse mammary gland. Cell Rep. 2015;11:1102–9. doi: 10.1016/j.celrep.2015.04.015. PubMed DOI PMC
Hanin G, Ferguson-Smith AC. The evolution of genomic imprinting: Epigenetic control of mammary gland development and postnatal resource control. Wiley Interdiscip Rev Syst Biol Med. 2020;12:e1476. doi: 10.1002/wsbm.1476. PubMed DOI
Sumbal J, Chiche A, Charifou E, Koledova Z, Li H. Primary Mammary Organoid Model of Lactation and Involution. Front Cell Dev Biol. 2020;8:68. doi: 10.3389/fcell.2020.00068. PubMed DOI PMC
Rodriguez-Fernandez L, et al. Isoform-specific function of calpains in cell adhesion disruption: studies in postlactational mammary gland and breast cancer. Biochem J. 2016;473:2893–909. doi: 10.1042/BCJ20160198. PubMed DOI
Rodriguez-Fernandez L, Company S, Zaragoza R, Vina JR, Garcia-Trevijano ER. Cleavage and activation of LIM kinase 1 as a novel mechanism for calpain 2-mediated regulation of nuclear dynamics. Sci Rep. 2021;11:16339. doi: 10.1038/s41598-021-95797-8. PubMed DOI PMC