Gender differences in the effect of a 0.11% breath alcohol concentration on forward and backward gait
Language English Country Great Britain, England Media electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
Grant support
MUNI/A/1639/2020
Specific University Research Grant provided by the Ministry of Education, Youth and Sports of the Czech Republic
PubMed
36335154
PubMed Central
PMC9637089
DOI
10.1038/s41598-022-23621-y
PII: 10.1038/s41598-022-23621-y
Knihovny.cz E-resources
- MeSH
- Gait MeSH
- Walking MeSH
- Breath Tests methods MeSH
- Ethanol MeSH
- Humans MeSH
- Alcoholic Intoxication * MeSH
- Sex Factors MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Ethanol MeSH
Alcohol contributes to a large number of diseases and health conditions related to injuries. The aim of our study was to evaluate gender differences in forward and backward gait when sober and at a breath alcohol concentration (BrAC) of 0.11%. Fifty females and fifty males participated in our study. The gait analysis was performed twice, when sober and after drinking a given amount of vodka mixed with orange juice. Under both conditions, participants were asked to walk forward and then backward on a Zebris platform. Multivariate analysis and the Mann-Whitney U test were used to compare the differences between genders when walking forward and backward. The Wilcoxon Signed Ranks test was used to compare the differences between 0.00% BrAC and 0.11% BrAC. Spearman's Rho was used to analyze the relationship between the AUDIT score, anthropometrical characteristics and the subjective score of drunkenness and gait parameters. The results show different strategies to improve stability during gait in women and men when intoxicated with alcohol. When intoxicated, males in forward gait increase their stability by increasing their foot rotation, while females increase their step width. A decrease in balance-related variables was observed in females when walking backward with a BrAC of 0.11%. Additionally, females tended to perform an increase in balance-related gait variables when subjectively feeling more drunk in both forward and backward gait. Different strategies to maintain stability during gait were observed in women and men. The results of our study show that alcohol intoxication has a greater impact on gait in females who tended to perform an increase in balance-related variables with an increase in their subjective score of drunkenness.
See more in PubMed
Arnold, Z., LaRose, D. & Agu, E. Smartphone inference of alcohol consumption levels from gait. In Proceedings—2015 IEEE International Conference on Healthcare Informatics, ICHI 2015 417–426 (Institute of Electrical and Electronics Engineers Inc., 2015).
World Health Organization. Global Status Report on Alcohol and Health 2018 (2018).
Baraona, E. et al. Gender Differences in Pharmacokinetics of Alcohol (2001). PubMed
Thomasson HS. Gender differences in alcohol metabolism physiological responses to ethanol. In: Galanter M, editor. Recent Developments in Alcoholism Volume 12 Alcoholism and Women. Kluwer Academic Publishers; 2002. pp. 163–179. PubMed
Wilsnack RW, Vogeltanz ND, Wilsnack SC, Robert HT. Gender differences in alcohol consumption and adverse drinking consequences: Cross-cultural patterns. Addiction. 2000;95:251–265. PubMed
Grant BF, Chou SP, Saha TD, Pickering RP, Kerridge BT, Ruan WJ, et al. Prevalence of 12-month alcohol use, high-risk drinking, and DSM-IV alcohol use disorder in the United States, 2001–2002 to 2012–2013: Results from the National Epidemiologic Survey on Alcohol and Related Conditions. JAMA Psychiat. 2017;74:911–923. PubMed PMC
Flores-Bonilla, A. Sex differences in the neurobiology of alcohol use disorder. Alcohol Res. Curr. Rev.40 (2020). PubMed PMC
Demura S, Uchiyama M. Influence of moderate alcohol ingestion on gait. Sport Sci. Health. 2008;4:21–26.
Mitoma H, Manto M, Shaikh AG. Mechanisms of ethanol-induced cerebellar ataxia: Underpinnings of neuronal death in the cerebellum. Int. J. Environ. Res. Public Health. 2021;18:8678. PubMed PMC
Stolze H, Klebe S, Petersen G, Raethjen J, Wenzelburger R, Witt K, et al. Typical features of cerebellar ataxic gait. J. Neurol. Neurosurg. Psychiatry. 2002;73:310–312. PubMed PMC
Jansen EC, Thyssen HH, Brynskov J. Gait analysis after intake of increasing amounts of alcohol. Z. Rechtsmed. 1985;94:103–107. PubMed
Fritz NE, Worstell AM, Kloos AD, Siles AB, White SE, Kegelmeyer DA. Backward walking measures are sensitive to age-related changes in mobility and balance. Gait Posture. 2013;37:593–597. PubMed
Kurz MJ, Wilson TW, Arpin DJ. Stride-time variability and sensorimotor cortical activation during walking. Neuroimage. 2012;59:1602–1607. PubMed
Hoogkamer W, Meyns P, Duysens J. Steps forward in understanding backward gait: From basic circuits to rehabilitation. Exerc. Sport Sci. Rev. 2014;42:23–29. PubMed
Balasukumaran T, Gottlieb U, Springer S. Spatiotemporal gait characteristics and ankle kinematics of backward walking in people with chronic ankle instability. Sci Rep. 2020;10:11515. PubMed PMC
Modig F, Patel M, Magnusson M, Fransson PA. Study II: Mechanoreceptive sensation is of increased importance for human postural control under alcohol intoxication. Gait Posture. 2012;35:419–427. PubMed
Oie KS, Kiemel T, Jeka JJ. Multisensory fusion: Simultaneous re-weighting of vision and touch for the control of human posture. Cogn. Brain Res. 2002;14:164–176. PubMed
Cho SH, Park JM, Kwon OY. Gender differences in three dimensional gait analysis data from 98 healthy Korean adults. Clin. Biomech. 2004;19:145–152. PubMed
Laufer Y. Age- and gender-related changes in the temporal-spatial characteristics of forwards and backwards gaits. Physiother. Res. Int. 2003;8:131–142. PubMed
di Nardo F, Mengarelli A, Maranesi E, Burattini L, Fioretti S. Gender differences in the myoelectric activity of lower limb muscles in young healthy subjects during walking. Biomed. Signal Process. Control. 2015;19:14–22.
Suffoletto B, Dasgupta P, Uymatiao R, Huber J, Flickinger K, Sejdic E. A preliminary study using smartphone accelerometers to sense gait impairments due to alcohol intoxication. J. Stud. Alcohol Drugs. 2020;81:505–510. PubMed PMC
McCabe SE. Gender differences in collegiate risk factors for heavy episodic drinking. J. Stud. Alcohol. 2002;63:49–56. PubMed
Bruinvels G, Burden RJ, McGregor AJ, Ackerman KE, Dooley M, Richards T, et al. Sport, exercise and the menstrual cycle: Where is the research? Br. J. Sports Med. 2017;51:487–488. PubMed
Lundin A, Hallgren M, Balliu N, Forsell Y. The use of alcohol use disorders identification test (AUDIT) in detecting alcohol use disorder and risk drinking in the general population: Validation of AUDIT using schedules for clinical assessment in neuropsychiatry. Alcohol Clin. Exp. Res. 2015;39:158–165. PubMed
Holstein SE, Barkell GA, Young MR. Caffeine increases alcohol self-administration, an effect that is independent of dopamine D2 receptor function. Alcohol. 2021;91:61–73. PubMed
Kalina K. Základy klinické adiktologie. Grada; 2008.
Kasović M, Štefan L, Zvonař M. Domain-specific and total sedentary behavior associated with gait velocity in older adults: The mediating role of physical fitness. Int. J. Environ. Res. Public Health. 2020;17:593. PubMed PMC
Štefan L, Kasović M, Zvonar M. Gait speed as a screening tool for foot pain and the risk of falls in community-dwelling older women: A cross-sectional study. Clin. Interv. Aging. 2020;15:1569–1574. PubMed PMC
Fransson PA, Modig F, Patel M, Gomez S, Magnusson M. Oculomotor deficits caused by 0.06% and 0.10% blood alcohol concentrations and relationship to subjective perception of drunkenness. Clin. Neurophysiol. 2010;121:2134–2142. PubMed
Cohen J. Statistical Power Analysis for the Behavioral Sciences. 2. Lawrence Erlbaum Associates; 1988.
Schäfer T, Schwarz MA. The meaningfulness of effect sizes in psychological research: Differences between sub-disciplines and the impact of potential biases. Front. Psychol. 2019;10:813. PubMed PMC
Peter A, Bennett K. SPSS for the Health and Behavioural Sciences. Thomson; 2008.
Wang GJ, Volkow ND, Fowler JS, Franceschi D, Wong CT, Pappas NR, et al. Alcohol intoxication induces greater reductions in brain metabolism in male than in female subjects. Alcohol. Clin. Exp. Res. 2003;27:909–917. PubMed
Rickenbacher E, Greve DN, Azma S, Pfeuffer J, Marinkovic K. Effects of alcohol intoxication and gender on cerebral perfusion: An arterial spin labeling study. Alcohol. 2011;45:725–737. PubMed PMC
Samson MM, Crowe A, de Vreede PL, et al. Differences in gait parameters at a preferred walking speed in healthy subjects due to age, height and body weight. Aging Clin. Exp. Res. 2001;13:16–21. PubMed
de Souza SAF, Faintuch J, Valezi AC, et al. Gait cinematic analysis in morbidly obese patients. Obes. Surg. 2005;15:1238–1242. PubMed
Valencia O, Araneda O, Cárcamo M, Carpes F, Guzmán-Venegas R. Relationship between lower limb anthropometry and temporo-spatial parameters in gait of young adults. Retos. 2018;33:1–258.
Schulleri KH, Johannsen L, Michel Y, et al. Sex differences in the association of postural control with indirect measures of body representations. Sci. Rep. 2022;12:4556. PubMed PMC
Fessler DMT, Haley KJ, Lal RD. Sexual dimorphism in foot length proportionate to stature. Ann. Hum. Biol. 2005;32(1):44–59. PubMed
Davoren MP, Demant J, Shiely F, et al. Alcohol consumption among university students in Ireland and the United Kingdom from 2002 to 2014: A systematic review. BMC Public Health. 2016;16:173. PubMed PMC
Turrisi R, Larimer ME, Mallett KA, Kilmer JR, Ray AE, Mastroleo NR, et al. A randomized clinical trial evaluating a combined alcohol intervention for high-risk college students. J. Stud. Alcohol Drugs. 2009;70:555–567. PubMed PMC
Beenstock J, Adams J, White M. The association between time perspective and alcohol consumption in university students: Cross-sectional study. Eur. J. Pub. Health. 2011;21:438–443. PubMed
Davoren MP, Shiely F, Byrne M, et al. Hazardous alcohol consumption among university students in Ireland: A cross-sectional study. BMJ Open. 2015;5:e006045. PubMed PMC
Sullivan EV, Rosenbloom MJ, Lim KO, Pfefferbaum A. Longitudinal changes in cognition, gait, and balance in abstinent and relapsed alcoholic men: Relationships to changes in brain structure. Neuropsychology. 2000;14(2):178–188. PubMed
Sullivan EV, Rose J, Pfefferbaum A. Mechanisms of postural control in alcoholic men and women: Biomechanical analysis of musculoskeletal coordination during quiet standing. Alcohol Clin. Exp. Res. 2010;34:528–537. PubMed PMC
Fein G, Smith S, Greenstein D. Gait and balance in treatment-naïve active alcoholics with and without a lifetime drug codependence. Alcohol Clin. Exp. Res. 2012;36:1550–1562. PubMed PMC
El Ansari W, Stock C, Mills C. Is alcohol consumption associated with poor academic achievement in university students? Int. J. Prev. Med. 2013;4(10):1175–1188. PubMed PMC
Bruijn SM, van Dieën JH. Control of human gait stability through foot placement. J. R. Soc. Interface. 2018;15:20170816. PubMed PMC
Stolze H, Kuhtz-Buschbeck JP, Mondwurf C, Boczek-Funcke A, Jöhnk K, Deuschl G, et al. Gait analysis during treadmill and overground locomotion in children and adults. Electroencephalogr. Clin. Neurophysiol./Electromyogr. Motor Control. 1997;105:490–497. PubMed
Shibasaki H, Fukuyama H, Hanakawa T. Neural control mechanisms for normal versus Parkinsonian gait. Prog. Brain Res. 2004;143:199–205. PubMed
Choi J, Bastian A. Adaptation reveals independent control networks for human walking. Nat. Neurosci. 2007;10:1055–1062. PubMed
Fritz NE, Worstell AM, Kloos AD, Siles AB, White SE, Kegelmeyer DA. Backward walking measures are sensitive to age-related changes in mobility and balance. Gait Posture. 2013;37:593–597. PubMed
Hackney ME, Earhart GM. Backward walking in Parkinson's disease. Mov. Disord. 2009;24:218–223. PubMed PMC
Gimunová M, Bozděch M, Skotáková A, Grün V, Válková H. Comparison of forward and backward gait in males with and without intellectual disabilities. J. Intellect. Disabil. Res. 2021;65:922–929. PubMed
Hackney ME, Earhart GM. The effects of a secondary task on forward and backward walking in Parkinson's disease. Neurorehabil. Neural Repair. 2010;24(1):97–106. PubMed PMC
Taylor B, Irving HM, Kanteres F, Room R, Borges G, Cherpitel C, Greenfield T, Rehm J. The more you drink, the harder you fall: A systematic review and meta-analysis of how acute alcohol consumption and injury or collision risk increase together. Drug Alcohol Depend. 2010;110:108–116. PubMed PMC
Hebenstreit F, Leibold A, Krinner S, Welsch G, Lochmann M, Eskofier BM. Effect of walking speed on gait sub phase durations. Hum. Mov. Sci. 2015;43:118–124. PubMed
Summerside EM, Kram R, Ahmed AA. Contributions of metabolic and temporal costs to human gait selection. J. R. Soc. Interface. 2018;15:20180197. PubMed PMC
Choi JES, Vaswani PA, Shadmehr R. Vigor of movements and the cost of time in decision making. J. Neurosci. 2014;34:1212–1223. PubMed PMC
Miller MA, Weafer J, Fillmore MT. Gender differences in alcohol impairment of simulated driving performance and driving-related skills. Alcohol Alcohol. 2009;44:586–593. PubMed PMC
Modig F, Patel M, Magnusson M, Fransson PA. Study I: Effects of 0.06% and 0.10% blood alcohol concentration on human postural control. Gait Posture. 2012;35:410–418. PubMed