This review summarizes current knowledge on several novel and emerging renal entities, including eosinophilic solid and cystic renal cell carcinoma (RCC), RCC with fibromyomatous stroma, anaplastic lymphoma kinase-rearranged RCC, low-grade oncocytic renal tumor, eosinophilic vacuolated tumor, thyroidlike follicular RCC, and biphasic hyalinizing psammomatous RCC. Their clinical features, gross and microscopic morphology, immunohistochemistry, and molecular and genetic features are described. The diagnosis of most of them rests on recognizing their morphologic features using immunohistochemistry. Accurate diagnosis of these entitles will further reduce the category of "unclassifiable renal carcinomas/tumors" and will lead to better clinical management and improved patient prognostication.

Department of Pathology and Laboratory Medicine Cumming School of Medicine University of Calgary Rockyview General Hospital 7007 14 Street Calgary Alberta T2V 1P9 Canada

Department of Pathology and Laboratory Medicine Cumming School of Medicine University of Calgary Rockyview General Hospital 7007 14 Street Calgary Alberta T2V 1P9 Canada https twitter com FSiadat

Department of Pathology Charles University Prague Faculty of Medicine in Plzeň University Hospital Plzen Alej Svobody 80 304 60 Pilsen Czech Republic

Clin Lab Med. 2023 Jun;43(2):275-298. doi: 10.1016/j.cll.2023.03.003. PubMed

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