A case of congenital multiple epiphyseal dysplasia from the Late Migration Period graveyard in Drnholec (Czech Republic)
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu kazuistiky, práce podpořená grantem, časopisecké články
PubMed
36455429
DOI
10.1016/j.ijpp.2022.11.003
PII: S1879-9817(22)00058-4
Knihovny.cz E-zdroje
- Klíčová slova
- Congenital defects, Disproporcional growth, Langobards, Skeletal dysplasia, Tooth cementum annulation (TCA),
- MeSH
- achondroplazie * MeSH
- dospělí MeSH
- hřbitovy MeSH
- lidé středního věku MeSH
- lidé MeSH
- osteochondrodysplazie * MeSH
- Perthesova nemoc * MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Česká republika MeSH
OBJECTIVE: To contribute to differential diagnosis of multiple epiphyseal dysplasia (MED) in archeological and clinical contexts. MATERIALS: A skeleton of a 30- to 45-year-old male (grave no. 806) from the Late Migration Period graveyard in Drnholec-Pod sýpkou (Czech Republic), radio-carbon dated to AD 492-530. METHODS: Morphological and metric analyses. RESULTS: Significant pathological changes were noted on ossa coxae and proximal ends of the femora, which appear similar to changes associated with Legg-Calvé-Perthes disease. X-ray examination made it possible to rule out pseudoachondroplasia, rickets and metabolic bone diseases. CONCLUSIONS: The finding was evaluated as a probable case of congenital multiple epiphyseal dysplasia. SIGNIFICANCE: This case will contribute to the construction of estimates of the occurrence of this disease in historical populations and can be instructive for diagnostics in current medical practice. LIMITATIONS: The final diagnosis is limited by the lack of genetic analysis. SUGGESTION FOR THE FUTURE RESEARCH: Further clarification leading to diagnosis will benefit from genetic analysis and evaluation of skeletal remains throughout Europe.
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