Sepsis is a clinical syndrome of systemic inflammation induced by infection, now defined as life-threatening organ dysfunction caused by a dysregulated immune response to infection [...].

Department of Anesthesiology and Intensive Medicine Medical School Comenius University Heydukova 10 812 50 Bratislava Slovakia

Department of Clinical Biochemistry Haematology and Immunology Na Homolce Hospital 140 00 Prague Czech Republic

Zobrazit více v PubMed

Singer M., Deutschman C.S., Seymour C.W., Shankar-Hari M., Annane D., Bauer M., Bellomo R., Bernard G.R., Chiche J.-D., Coopersmith C.M., et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3) JAMA. 2016;315:801–810. doi: 10.1001/jama.2016.0287. PubMed DOI PMC

Ai-Obeuidallah M., Jarkovská D., Valešova L., Horák J., Jedlička J., Nalos L., Chvojka J., Švíglerová J., Kuncová J., Beneš J., et al. SOFA score, Hemodynamics and body temperature allow earlky discrimination between porcine peritonitis-induced sepsis and peritonitis-induced septic shock. J. Pers. Med. 2021;11:164. doi: 10.3390/jpm11030164. PubMed DOI PMC

Shih H.-J., Chang C.-Y., Chiang M., Le V.L., Hsu H.-J., Huang C.-J. Simultaneous Inhibition of Three Major Cytokines and Its Therapeutic Effects: A Peptide-based Novel Therapy against Endotoxemia in Mice. J. Pers. Med. 2021;11:436. doi: 10.3390/jpm11050436. PubMed DOI PMC

Valenzuela-Mendez B., Valenzuela-Sáncjhez F., Rodriguez-Gutiérrrez J.F., Bohollo-de-Austria R., Estella Á., Martínez-García P., González-García M.Á., Rello J. Plasma levels of mid-regional proadrenomedullin accurately identify H1N1 pdm09 Influenza virus patients with risk of intensive care admission and mortality in the emergency department. J. Pers Med. 2022;12:84. doi: 10.3390/jpm12010084. PubMed DOI PMC

Geven C., Kox M., Pickkers P. Adrenomedullin and Adrenomedullin-targeted therapy as treatment strategies relevant for sepsis. Front. Immunol. 2018;9:292. doi: 10.3389/fimmu.2018.00292. PubMed DOI PMC

Saeed K., Wilson D.C., Bloos F., Schuetz P., van der Does Y., Melander O., Hausfater P., Legramante J.M., Claessens Y.-E., Amin D., et al. The early identification of disease progression in patients with suspected infection presenting to the emergency department: A multicenter derivation and validation study. Crit. Care. 2019;23:23. PubMed PMC

Zazula R., Moravec M., Pehal F., Nejtek T., Protuš M., Müller M. Myristic acid serum levels and their significance for diagnosis of systemic inflammatory response, sepsis and bacteraemia. J. Pers. Med. 2021;11:306. doi: 10.3390/jpm11040306. PubMed DOI PMC

Cambiaghi A. Doctoral Dissertation. Politecnico di Milano; Milan, Italy: 2017. Metabolomics in Sepsis and Septic Shock.

Kauppi A.M., Edin A., Ziegler I., Mölling P., Sjöstedt A., Gylfe Å., Strålin K., Johansson A. Metabolites in blood for prediction of bacteremic sepsis in the emergency room. PLoS ONE. 2016;11:e0147670. doi: 10.1371/journal.pone.0147670. PubMed DOI PMC

Dragoescu A.N., Padureanu V., Stanculescu A.D., Chiuțu L.C., Florescu D.N., Gheonea I.A., Pădureanu R., Stepan A., Streba C.T., Drocaș A.I., et al. Presepsin as a Potentuial prognostic marker for sepsis according actual practice guidelines. J. Pers. Med. 2021;11:2. doi: 10.3390/jpm11010002. PubMed DOI PMC

Iglesias J., Vassalo A.V., Liesenfeld O., Levine J.S., Patel V.V., Sullivan J.B., Cavanaugh J.B., Elbaga Y., Sweeney T.E. A 33 mRNA Classifier is able to produce inflammopathic, Adaptive, and Coagulopathic Endotypes with Prognostic Significance: The outcomes of metabolic resuscitation using Ascorbic acid, thiamine, and glucocortoides in the early treatment of sepsis (ORANGES) trial. J. Pers. Med. 2021;11:9. PubMed PMC

Sweeney T.E., Azad T., Donato M., Haynes W.A., Perumal T.M., Henao R., Bermejo-Martin J.F., Almansa R., Tamayo E., Howrylak J.A., et al. Unsupervised Analysis of Transcriptomics in Bacterial Sepsis Across Multiple Datasets Reveals Three Robust Clusters. Crit. Care Med. 2018;46:915–925. doi: 10.1097/CCM.0000000000003084. PubMed DOI PMC

Virág M., Leiner T., Rottler M., Ocskay K., Molnar Z. Individualized Hemodynamic Management in Sepsis. J. Pers. Med. 2021;11:157. doi: 10.3390/jpm11020157. PubMed DOI PMC