AIMS: Currently, the only method used to differentiate between MIBC and NMIBC is transurethral resection of the bladder tumour (TURBT). Magnetic resonance and Vesical Imaging-Reporting and Data System (VI-RADS) would allow for discrimination between NMIBC and MIBC. We evaluate the sensitivity and specificity of VI-RADS in the diagnosis of muscle-invasive bladder cancer and discuss its value in everyday urological practice. METHODS: 64 patients with bladder cancer (BC) were enrolled into this prospective study. Multiparametric magnetic resonance imaging (mpMRI) was performed before transurethral resection of the bladder tumour (TURBT) and evaluated using the VI-RADS score. Score were compared to histopathology results. We evaluated the sensitivity, specificity, positive and negative predictive value of this system using both cut-off VI-RADS ≥ 3 and ≥ 4. RESULTS: Sensitivity of 92.3% (95%CI: 64.0; 99.8), specificity of 81.4% (95%CI: 69.1; 90.3), positive predictive value of 52.2% (95%CI: 30.6; 73.2) and negative predictive value of 98.0% (95%CI: 89.1; 99.9) was determined using cut off VI-RADS ≥ 3, while sensitivity of 76.9% (95%CI: 46.2; 95.0), specificity of 91.5% (95%CI: 81.3; 97.2), positive predictive value of 66.7% (95%CI: 38.4; 88.2), and negative predictive value of 94.7% (95%CI: 85.4; 98.9) was determined using cut-off VI-RADS ≥ 4. Based on our results, we consider the optimal cut-off point to be VI-RADS ≥ 3 with the overall prediction accuracy of 83.3% (95%CI: 72.7; 91.1). CONCLUSIONS: We acknowledge that mpMRI provides valuable information with regard to BC staging, however, despite its high overall accuracy, we do not consider the VI-RADS could replace TURBT in discrimination between non-muscle invasive and MIBC.

Department of Applied Mathematics Faculty of Electrical Engineering and Computer Science VSB Technical University Ostrava Czech Republic

Department of Deputy Director for Science and Research University Hospital Ostrava Czech Republic

Department of Imaging Methods Faculty of Medicine University of Ostrava Czech Republic

Department of Molecular and Clinical Pathology and Medical Genetics Faculty of Medicine University of Ostrava Czech Republic

Department of Pathology Faculty of Medicine in Pilzen Charles University Pilzen Czech Republic

Department of Pathology University Hospital Ostrava Czech Republic

Department of Radiology University Hospital Ostrava Czech Republic

Department of Surgical Studies Faculty of Medicine University of Ostrava Czech Republic

Department of Urology University Hospital Ostrava Czech Republic

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EAU Guidelines. Edn. presented at the EAU Annual Congress Milan 2021. ISBN 978-94-92671-13-4.

Pecoraro M, Takeuchi M, Vargas HA, Muglia VF, Cipollari S, Catalano C, Panebianco V. Overview of VI-RADS in Bladder Cancer. AJR Am J Roentgenol 2020;214(6):1259-68. doi: 10.2214/AJR.20.22763 PubMed DOI

Cumberbatch MGK, Foerster B, Catto JWF, Kamat AM, Kassouf W, Jubber I, Shariat SF, Sylvester RJ, Gontero P. Repeat Transurethral Resection in Non-muscle-invasive Bladder Cancer: A Systematic Review. Eur Urol 2018;73(6):925-33. doi: 10.1016/j.eururo.2018.02.014 PubMed DOI

Panebianco V, Narumi Y, Altun E, Bochner BH, Efstathiou JA, Hafeez S, Huddart R, Kennish S, Lerner S, Montironi R, Muglia VF, Salomon G, Thomas S, Vargas HA, Witjes JA, Takeuchi M, Barentsz J, Catto JWF. Multiparametric Magnetic Resonance Imaging for Bladder Cancer: Development of VI-RADS (Vesical Imaging-Reporting And Data System). Eur Urol 2018;74(3):294-306. doi: 10.1016/j.eururo.2018.04.029 PubMed DOI

Panebianco V, Pecoraro M, Del Giudice F, Takeuchi M, Muglia VF, Messina E, Cipollari S, Giannarini G, Catalano C, Narumi Y. VI-RADS for Bladder Cancer: Current Applications and Future Developments. J Magn Reson Imaging 2022;55(1):23-36. doi: 10.1002/jmri.27361 PubMed DOI

Séguier D, Puech P, Kool R, Dernis L, Gabert H, Kassouf W, Villers A, Marcq G. Multiparametric magnetic resonance imaging for bladder cancer: a comprehensive systematic review of the Vesical Imaging-Reporting and Data System (VI-RADS) performance and potential clinical applications. Ther Adv Urol 2021;13:17562872211039583. doi: 10.1177/17562872211039583 PubMed DOI

Woo S, Panebianco V, Narumi Y, Del Giudice F, Muglia VF, Takeuchi M, Ghafoor S, Bochner BH, Goh AC, Hricak H, Catto JWF, Vargas HA. Diagnostic Performance of Vesical Imaging Reporting and Data System for the Prediction of Muscle-invasive Bladder Cancer: A Systematic Review and Meta-analysis. Eur Urol Oncol 2020;3(3):306-15. doi: 10.1016/j.euo.2020.02.007 Erratum in: Eur Urol Oncol 2020;3(6):811. PubMed DOI

Valerio M, Zini C, Fierro D, Giura F, Colarieti A, Giuliani A, Laghi A, Catalano C, Panebianco V. 3T multiparametric MRI of the prostate: Does intravoxel incoherent motion diffusion imaging have a role in the detection and stratification of prostate cancer in the peripheral zone? Eur J Radiol 2016;85(4):790-4. doi: 10.1016/j.ejrad.2016.01.006 PubMed DOI

Paner GP, Montironi R, Amin MB. Challenges in Pathologic Staging of Bladder Cancer: Proposals for Fresh Approaches of Assessing Pathologic Stage in Light of Recent Studies and Observations Pertaining to Bladder Histoanatomic Variances. Adv Anat Pathol 2017;24(3):113-27. doi: 10.1097/PAP.0000000000000152 PubMed DOI

Verma S, Rajesh A, Prasad SR, Gaitonde K, Lall CG, Mouraviev V, Aeron G, Bracken RB, Sandrasegaran K. Urinary bladder cancer: role of MR imaging. Radiographics 2012;32(2):371-87. doi: 10.1148/rg.322115125 PubMed DOI

Erkoc M, Otunctemur A, Bozkurt M, Can O, Atalay HA, Besiroglu H, Danis E, Degirmentepe RB. The efficacy and reliability of VI-RADS in determining candidates for repeated transurethral resection in patients with high-risk non-muscle invasive bladder cancer. Int J Clin Pract 2021;75(9):e14584. doi: 10.1111/ijcp.14584 PubMed DOI

Akcay A, Yagci AB, Celen S, Ozlulerden Y, Turk NS, Ufuk F. VI-RADS score and tumor contact length in MRI: A potential method for the detection of muscle invasion in bladder cancer. Clin Imaging 2021;77:25-36. doi: 10.1016/j.clinimag.2021.02.026 PubMed DOI

Liu S, Xu F, Xu T, Yan Y, Yao X, Tang G. Evaluation of Vesical Imaging-Reporting and Data System (VI-RADS) scoring system in predicting muscle invasion of bladder cancer. Transl Androl Urol 2020;9(2):445-51. doi: 10.21037/tau.2020.02.16 PubMed DOI

Marchioni M, Primiceri G, Delli Pizzi A, Basilico R, Berardinelli F, Mincuzzi E, Castellucci R, Sessa B, Di Nicola M, Schips L. Could Bladder Multiparametric MRI Be Introduced in Routine Clinical Practice? Role of the New VI-RADS Score: Results From a Prospective Study. Clin Genitourin Cancer 2020;18(5):409-15.e1. doi: 10.1016/j.clgc.2020.03.002 PubMed DOI

Hong SB, Lee NK, Kim S, Son IW, Ha HK, Ku JY, Kim KH, Park WY. Vesical Imaging-Reporting and Data System for Multiparametric MRI to Predict the Presence of Muscle Invasion for Bladder Cancer. J Magn Reson Imaging 2020;52(4):1249-56. doi: 10.1002/jmri.27141 PubMed DOI

Gmeiner J, Garstka N, Helbich TH, Shariat SF, Baltzer PA. Vesical Imaging Reporting and Data System (VI-RADS): Are the individual MRI sequences equivalent in diagnostic performance of high grade NMIBC and MIBC? Eur J Radiol 2021;142:109829. doi: 10.1016/j.ejrad.2021.109829 PubMed DOI

Luo C, Huang B, Wu Y, Chen J, Chen L. Use of Vesical Imaging-Reporting and Data System (VI-RADS) for detecting the muscle invasion of bladder cancer: a diagnostic meta-analysis. Eur Radiol 2020;30(8):4606-14. doi: 10.1007/s00330-020-06802-z PubMed DOI

Sakamoto K, Ito M, Ikuta S, Nakanishi Y, Kataoka M, Takemura K, Suzuki H, Tobisu K, Kamai T, Koga F. Detection of Muscle-Invasive Bladder Cancer on Biparametric MRI Using Vesical Imaging-Reporting and Data System and Apparent Diffusion Coefficient Values (VI-RADS/ADC) Bladder Cancer 2020;6(2):161-9. doi: 10.3233/BLC-190267 DOI

Mariappan P, Lavin V, Phua CQ, Khan SAA, Donat R, Smith G. Predicting Grade and Stage at Cystoscopy in Newly Presenting Bladder Cancers-a Prospective Double-Blind Clinical Study. Urology 2017;109:134-9. doi: 10.1016/j.urology.2017.08.007 PubMed DOI

Barchetti G, Simone G, Ceravolo I, Salvo V, Campa R, Del Giudice F, Berardinis ED, Buccilli D, Catalano C, Gallucci M, Catto JWF, Panebianco V. Multiparametric MRI of the bladder: inter-observer agreement and accuracy with the Vesical Imaging-Reporting and Data System (VI-RADS) at a single reference center. Eur Radiol 2019;29(10):5498-5506. doi: 10.1007/s00330-019-06117-8 PubMed DOI

Del Giudice F, Barchetti G, De Berardinis E, Pecoraro M, Salvo V, Simone G, Sciarra A, Leonardo C, Gallucci M, Catalano C, Catto JWF, Panebianco V Prospective Assessment of Vesical Imaging Reporting and Data System (VI-RADS) and Its Clinical Impact on the Management of High-risk Non-muscle-invasive Bladder Cancer Patients Candidate for Repeated Transurethral Resection. Eur Urol 2020;77(1):101-9. doi: 10.1016/j.eururo.2019.09.029 PubMed DOI

Diana P, Lughezzani G, Saita A, Uleri A, Frego N, Contieri R, Buffi N, Balzarini L, D'Orazio F, Piergiuseppe C, Elefante MG, Lazzeri M, Guazzoni G, Casale P, Hurle R. Head-to-Head Comparison Between High-Resolution Microultrasound Imaging and Multiparametric MRI in Detecting and Local Staging of Bladder Cancer: The BUS-MISS Protocol. Bladder Cancer 2022;8(2):119-27. doi: 10.3233/BLC-211611 DOI