JavaScript is NOT enabled !

Please enable JavaScript.

Article

PubMed

This record comes from PubMed

Traditional and Disease-Specific Risk Factors for Cardiovascular Events in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Multinational Retrospective Study

Moiseev, Sergey
Author Moiseev, Sergey S. Moiseev, MD, Professor, Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University, and Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia
Bulanov, Nikolay
Author Bulanov, Nikolay ORCID N. Bulanov, MD, P. Novikov, MD, Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University, Moscow, Russia
Crnogorac, Matija
Author Crnogorac, Matija M. Crnogorac, MD, K. Galesic, MD, Professor, Department of Nephrology and Dialysis, Dubrava University Hospital, Zagreb, Croatia
Direskeneli, Haner
Author Direskeneli, Haner H. Direskeneli, MD, Professor, U. Gazel, MD, Department of Internal Medicine, Division of Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey
Galesic, Kresimir
Author Galesic, Kresimir M. Crnogorac, MD, K. Galesic, MD, Professor, Department of Nephrology and Dialysis, Dubrava University Hospital, Zagreb, Croatia
Gazel, Ummugulsum
Author Gazel, Ummugulsum ORCID H. Direskeneli, MD, Professor, U. Gazel, MD, Department of Internal Medicine, Division of Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey
Geetha, Duvuru
Author Geetha, Duvuru D. Geetha, MD, Division of Nephrology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
Guillevin, Loic
Author Guillevin, Loic L. Guillevin, MD, Professor, B. Terrier, PhD, Professor, Department of Internal Medicine, National Referral Center for Rare Systemic and Autoimmune Diseases, Hôpital Cochin, Paris, France
Hrušková, Zdenka
Author Hrušková, Zdenka Z. Hrušková, MD, V. Satrapová, MD, V. Tesar, MD, Professor, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
Little, Mark A
Author Little, Mark A M.A. Little, MD, Professor, Trinity Health Kidney Centre, Trinity Translational Medicine Institute, and Irish Centre for Vascular Biology, Tallaght University Hospital, Dublin, Ireland
O'Neill, Liam
Author O'Neill, Liam ORCID L. O'Neill, MD, University Hospital Galway, Dublin, Ireland
Makarov, Egor
Author Makarov, Egor E. Makarov, MD, Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia
McAdoo, Stephen P
Author McAdoo, Stephen P S.P. McAdoo, PhD, C.D. Pusey, MD, Professor, J. Silva, MD, Department of Immunology and Inflammation, Centre for Inflammatory Disease, Imperial College London, London, UK
Mohammad, Aladdin J
Author Mohammad, Aladdin J ORCID A.J. Mohammad, MD, Department of Rheumatology, Clinical Sciences-Lund, Lund University, Lund, Sweden, and Vasculitis and Lupus Clinic, Addenbrooke's Hospital, Cambridge University Hospitals, Cambridge, UK
Moran, Sarah
Author Moran, Sarah S. Moran, MD, Trinity Health Kidney Centre, Trinity Translational Medicine Institute, Dublin, Ireland
Novikov, Pavel
Author Novikov, Pavel N. Bulanov, MD, P. Novikov, MD, Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University, Moscow, Russia
Pusey, Charles D
Author Pusey, Charles D S.P. McAdoo, PhD, C.D. Pusey, MD, Professor, J. Silva, MD, Department of Immunology and Inflammation, Centre for Inflammatory Disease, Imperial College London, London, UK
Rahmattulla, Chinar
Author Rahmattulla, Chinar C. Rahmattulla, PhD, Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands
Satrapová, Veronika
Author Satrapová, Veronika Z. Hrušková, MD, V. Satrapová, MD, V. Tesar, MD, Professor, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
Silva, Joana
Author Silva, Joana S.P. McAdoo, PhD, C.D. Pusey, MD, Professor, J. Silva, MD, Department of Immunology and Inflammation, Centre for Inflammatory Disease, Imperial College London, London, UK
Suvorov, Alexander
Author Suvorov, Alexander A. Suvorov, MD, Centre for Analysis of Complex Systems, Sechenov First Moscow State Medical University, Moscow, Russia
Tesar, Vladimír
Author Tesar, Vladimír Z. Hrušková, MD, V. Satrapová, MD, V. Tesar, MD, Professor, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
Terrier, Benjamin
Author Terrier, Benjamin L. Guillevin, MD, Professor, B. Terrier, PhD, Professor, Department of Internal Medicine, National Referral Center for Rare Systemic and Autoimmune Diseases, Hôpital Cochin, Paris, France
Willeit, Peter
Author Willeit, Peter P. Willeit, PhD, Professor, Clinical Epidemiology Team, Medical University of Innsbruck, Innsbruck, Austria, and Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
Zhao, Ming-Hui
Author Zhao, Ming-Hui M.H. Zhao, MD, Professor, Renal Division, Peking University First Hospital, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China
Kronbichler, Andreas
Author Kronbichler, Andreas ORCID A. Kronbichler, PhD, D.R.W. Jayne, MD, Professor, Vasculitis and Lupus Clinic, Addenbrooke's Hospital, Cambridge University Hospitals, and Department of Medicine, University of Cambridge, Cambridge, UK. ak2283@cam.ac.uk
Jayne, David R W
Author Jayne, David R W A. Kronbichler, PhD, D.R.W. Jayne, MD, Professor, Vasculitis and Lupus Clinic, Addenbrooke's Hospital, Cambridge University Hospitals, and Department of Medicine, University of Cambridge, Cambridge, UK

The Journal of rheumatology. 2023 Sep ; 50 (9) : 1145-1151. [epub] 20230115

J Rheumatol
ISSN 1499-2752 | 0315-162X
Source

Language English Country Canada Media print-electronic

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link https://www.medvik.cz/link/pmid36642436

PubMed 36642436
DOI 10.3899/jrheum.220851
PII: jrheum.220851
Knihovny.cz E-resources

Keywords
ANCA-associated vasculitis, cardiovascular events, myocardial infarction, risk factors, stroke,
MeSH
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis * MeSH
Kidney MeSH
Humans MeSH
Antibodies, Antineutrophil Cytoplasmic * MeSH
Retrospective Studies MeSH
Risk Factors MeSH
Check Tag
Humans MeSH
Publication type
Journal Article MeSH
Research Support, Non-U.S. Gov't MeSH
Names of Substances
Antibodies, Antineutrophil Cytoplasmic * MeSH

OBJECTIVE: To investigate the occurrence of cardiovascular events (CVEs) in a large cohort of patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) across the European Union, China, Turkey, Russia, the United Kingdom, and the USA. METHODS: Patients with a definite diagnosis of AAV who were followed for ≥ 3 months and had sufficient documentation were included. Data on myocardial infarction (MI) and stroke were collected retrospectively from tertiary vasculitis centers. Univariate and multivariate Cox regression models were used to estimate hazard ratios (HRs) and 95% CIs. RESULTS: Over a median follow-up of 62.0 months (IQR 22.6-100.0), CVEs (mostly MIs) occurred in 245 (10.7%) of 2286 patients with AAV, with a higher frequency in China and the UK. On multivariate regression analysis, older age (55-64.9 yrs, HR 2.93, 95% CI 1.99-4.31), smoking (HR 1.98, 95% CI 1.48-2.64), Chinese origin (HR 4.24, 95% CI 3.07-5.85), and pulmonary (HR 1.50, 95% CI 1.09-2.06) and kidney (HR 3.02, 95% CI 2.08-4.37) involvement were independent variables associated with a higher occurrence of CVEs. CONCLUSION: We showed that geographic region and both traditional and disease-specific (kidney involvement in particular) factors were independently associated with CVEs. Proper assessment and management of modifiable cardiovascular (CV) risk factors are essential for prevention of CV morbidity in patients with AAV.

A J Mohammad MD Department of Rheumatology Clinical Sciences Lund Lund University Lund Sweden and Vasculitis and Lupus Clinic Addenbrooke's Hospital Cambridge University Hospitals Cambridge UK

A Kronbichler PhD D R W Jayne MD Professor Vasculitis and Lupus Clinic Addenbrooke's Hospital Cambridge University Hospitals and Department of Medicine University of Cambridge Cambridge UK

A Suvorov MD Centre for Analysis of Complex Systems Sechenov 1st Moscow State Medical University Moscow Russia

C Rahmattulla PhD Department of Pathology Leiden University Medical Center Leiden the Netherlands

D Geetha MD Division of Nephrology Department of Medicine Johns Hopkins University Baltimore Maryland USA

E Makarov MD Faculty of Medicine Lomonosov Moscow State University Moscow Russia

H Direskeneli MD Professor U Gazel MD Department of Internal Medicine Division of Rheumatology Marmara University School of Medicine Istanbul Turkey

L Guillevin MD Professor B Terrier PhD Professor Department of Internal Medicine National Referral Center for Rare Systemic and Autoimmune Diseases Hôpital Cochin Paris France

L O'Neill MD University Hospital Galway Dublin Ireland

M A Little MD Professor Trinity Health Kidney Centre Trinity Translational Medicine Institute and Irish Centre for Vascular Biology Tallaght University Hospital Dublin Ireland

M Crnogorac MD K Galesic MD Professor Department of Nephrology and Dialysis Dubrava University Hospital Zagreb Croatia

M H Zhao MD Professor Renal Division Peking University 1st Hospital Key Laboratory of Renal Disease Ministry of Health of China Key Laboratory of CKD Prevention and Treatment Ministry of Education of China Beijing China