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Autor
Bulanov, Nikolay 1 Crnogorac, Matija 1 Direskeneli, Haner 1 Galesic, Kresimir 1 Gazel, Ummugulsum 1 Geetha, Duvuru 1 Guillevin, Loic 1 Hrušková, Zdenka 1 Jayne, David R W 1 Kronbichler, Andreas 1 Little, Mark A 1 Makarov, Egor 1 McAdoo, Stephen P 1 Mohammad, Aladdin J 1 Moiseev, Sergey 1 Moran, Sarah 1 Novikov, Pavel 1 O'Neill, Liam 1 Pusey, Charles D 1 Rahmattulla, Chinar 1
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Pracoviště
A J Mohammad MD Department of Rheumat... 1 A Kronbichler PhD D R W Jayne MD Prof... 1 A Suvorov MD Centre for Analysis of C... 1 C Rahmattulla PhD Department of Patho... 1 D Geetha MD Division of Nephrology De... 1 E Makarov MD Faculty of Medicine Lomo... 1 H Direskeneli MD Professor U Gazel MD... 1 L Guillevin MD Professor B Terrier Ph... 1 L O'Neill MD University Hospital Galw... 1 M A Little MD Professor Trinity Healt... 1 M Crnogorac MD K Galesic MD Professor... 1 M H Zhao MD Professor Renal Division ... 1 N Bulanov MD P Novikov MD Tareev Clin... 1 P Willeit PhD Professor Clinical Epid... 1 S Moiseev MD Professor Tareev Clinic ... 1 S Moran MD Trinity Health Kidney Cent... 1 S P McAdoo PhD C D Pusey MD Professor... 1 Z Hrušková MD 5 Satrapová MD 5 Tesar ... 1
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Autor
Bulanov, Nikolay 1 Crnogorac, Matija 1 Direskeneli, Haner 1 Galesic, Kresimir 1 Gazel, Ummugulsum 1 Geetha, Duvuru 1 Guillevin, Loic 1 Hrušková, Zdenka 1 Jayne, David R W 1 Kronbichler, Andreas 1 Little, Mark A 1 Makarov, Egor 1 McAdoo, Stephen P 1 Mohammad, Aladdin J 1 Moiseev, Sergey 1 Moran, Sarah 1 Novikov, Pavel 1 O'Neill, Liam 1 Pusey, Charles D 1 Rahmattulla, Chinar 1
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Pracoviště
A J Mohammad MD Department of Rheumat... 1 A Kronbichler PhD D R W Jayne MD Prof... 1 A Suvorov MD Centre for Analysis of C... 1 C Rahmattulla PhD Department of Patho... 1 D Geetha MD Division of Nephrology De... 1 E Makarov MD Faculty of Medicine Lomo... 1 H Direskeneli MD Professor U Gazel MD... 1 L Guillevin MD Professor B Terrier Ph... 1 L O'Neill MD University Hospital Galw... 1 M A Little MD Professor Trinity Healt... 1 M Crnogorac MD K Galesic MD Professor... 1 M H Zhao MD Professor Renal Division ... 1 N Bulanov MD P Novikov MD Tareev Clin... 1 P Willeit PhD Professor Clinical Epid... 1 S Moiseev MD Professor Tareev Clinic ... 1 S Moran MD Trinity Health Kidney Cent... 1 S P McAdoo PhD C D Pusey MD Professor... 1 Z Hrušková MD 5 Satrapová MD 5 Tesar ... 1
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PubMed
36642436
DOI
10.3899/jrheum.220851
Knihovny.cz E-zdroje
OBJECTIVE: To investigate the occurrence of cardiovascular events (CVEs) in a large cohort of patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) across the European Union, China, Turkey, Russia, the United Kingdom, and the USA. METHODS: Patients with a definite diagnosis of AAV who were followed for ≥ 3 months and had sufficient documentation were included. Data on myocardial infarction (MI) and stroke were collected retrospectively from tertiary vasculitis centers. Univariate and multivariate Cox regression models were used to estimate hazard ratios (HRs) and 95% CIs. RESULTS: Over a median follow-up of 62.0 months (IQR 22.6-100.0), CVEs (mostly MIs) occurred in 245 (10.7%) of 2286 patients with AAV, with a higher frequency in China and the UK. On multivariate regression analysis, older age (55-64.9 yrs, HR 2.93, 95% CI 1.99-4.31), smoking (HR 1.98, 95% CI 1.48-2.64), Chinese origin (HR 4.24, 95% CI 3.07-5.85), and pulmonary (HR 1.50, 95% CI 1.09-2.06) and kidney (HR 3.02, 95% CI 2.08-4.37) involvement were independent variables associated with a higher occurrence of CVEs. CONCLUSION: We showed that geographic region and both traditional and disease-specific (kidney involvement in particular) factors were independently associated with CVEs. Proper assessment and management of modifiable cardiovascular (CV) risk factors are essential for prevention of CV morbidity in patients with AAV.
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