Enantioselective Synthesis of Spiro Heterocyclic Compounds Using a Combination of Organocatalysis and Transition-Metal Catalysis
Status PubMed-not-MEDLINE Language English Country United States Media print-electronic
Document type Journal Article, Review
Grant support
22-11234S
Czech Science Foundation
UNCE/SCI/014.
Charles University Research Centre
PubMed
36703545
DOI
10.1002/tcr.202200284
Knihovny.cz E-resources
- Keywords
- Aminocatalysis, Brønsted acid, NHC, Organocatalysis, Transition metal,
- MeSH
- Heterocyclic Compounds * MeSH
- Catalysis MeSH
- Spiro Compounds * MeSH
- Stereoisomerism MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Names of Substances
- Heterocyclic Compounds * MeSH
- Spiro Compounds * MeSH
Over the last ten years, the combination of organocatalysis with transition metal (TM) catalysis has become one of the most important toolboxes used for synthesizing optically pure compounds containing chiral quaternary centers, including spiro heterocyclic molecules. The dominant method in the enantioselective synthesis of spiro heterocyclic compounds based on synergistic catalysis includes chiral aminocatalysis and NHC catalysis, as already established covalent organocatalytic strategies. Another area of organocatalysis widely combined with TM catalysis producing enantiomerically enriched spiro heterocyclic compounds is non-covalent catalysis, dominated by chiral phosphoric acids, thiourea, and squaramide derivatives. This review article aims to summarize enantioselective methods used for constructing spirocyclic heterocycles based on a combination of organocatalysis and transition metal catalysis.
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