Microbe-mediated intestinal NOD2 stimulation improves linear growth of undernourished infant mice
Language English Country United States Media print-electronic
Document type Journal Article
- MeSH
- Acetylmuramyl-Alanyl-Isoglutamine pharmacology therapeutic use MeSH
- Cell Wall chemistry MeSH
- Epithelial Cells microbiology physiology MeSH
- Germ-Free Life MeSH
- Insulin-Like Growth Factor I metabolism MeSH
- Insulin metabolism MeSH
- Lactobacillaceae * physiology MeSH
- Mice MeSH
- Malnutrition * physiopathology therapy MeSH
- Growth Disorders physiopathology therapy MeSH
- Growth * drug effects physiology MeSH
- Nod2 Signaling Adaptor Protein * metabolism MeSH
- Intestines * microbiology physiology MeSH
- Gastrointestinal Microbiome * physiology MeSH
- Intestinal Mucosa microbiology physiology MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Acetylmuramyl-Alanyl-Isoglutamine MeSH
- Insulin-Like Growth Factor I MeSH
- Insulin MeSH
- mifamurtide MeSH Browser
- Nod2 protein, mouse MeSH Browser
- Nod2 Signaling Adaptor Protein * MeSH
The intestinal microbiota is known to influence postnatal growth. We previously found that a strain of Lactiplantibacillus plantarum (strain LpWJL) buffers the adverse effects of chronic undernutrition on the growth of juvenile germ-free mice. Here, we report that LpWJL sustains the postnatal growth of malnourished conventional animals and supports both insulin-like growth factor-1 (IGF-1) and insulin production and activity. We have identified cell walls isolated from LpWJL, as well as muramyl dipeptide and mifamurtide, as sufficient cues to stimulate animal growth despite undernutrition. Further, we found that NOD2 is necessary in intestinal epithelial cells for LpWJL-mediated IGF-1 production and for postnatal growth promotion in malnourished conventional animals. These findings indicate that, coupled with renutrition, bacteria cell walls or purified NOD2 ligands have the potential to alleviate stunting.
CarMeN Laboratory INSERM INRAE Université Claude Bernard Lyon 1 69310 Pierre Bénite France
Genomics Core Facility European Molecular Biology Laboratory 69117 Heidelberg Germany
Université Paris Saclay INRAE AgroParisTech Micalis Institute 78350 Jouy en Josas France
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