The European Intergroup for Childhood Non-Hodgkin Lymphoma (EICNHL) was established 25 years ago with the goal to facilitate clinical trials and research collaborations in the field both within Europe and worldwide. Since its inception, much progress has been made whereby major improvements in outcomes have been achieved. In this Review, we describe the different diagnostic entities of non-Hodgkin lymphoma in children and young adults describing key features of each entity and outlining clinical achievements made in the context of the EICNHL framework. Furthermore, we provide an overview of advances in biopathology with an emphasis on the role of biological studies and how they have shaped available treatments. Finally, for each entity, we describe future goals, upcoming clinical trials, and highlight areas of research that require our focus going forward.

Biostatistics Unit Gustave Roussy Cancer Campus Villejuif France

Bone Marrow Transplantation and Pediatric Hematology and Oncology Wroclaw Medical University Wroclaw Poland

Clinical Research Center National Hospital Organization Nagoya Medical Center Aichi Japan

Department of Paediatric Haematology Oncology and Palliative Care Cambridge University Hospitals NHS Foundation Trust Cambridge

Department of Paediatric Oncology Sahlgrenska University Hospital Gothenburg Sweden

Department of Pathological Anatomy San Bortolo Hospital Vicenza Italy

Department of Pathology Medical University of Vienna Vienna Austria

Department of Pathology The Royal Marsden Hospital London UK

Department of Pediatric and Adolescent Oncology Gustave Roussy Université Paris Saclay Villejuif France

Department of Pediatric Hematology and Oncology Charles University and University Hospital Motol Prague Czech Republic

Department of Pediatric Hematology and Oncology Justus Liebig University Giessen Giessen Germany

Department of Pediatric Hematology and Oncology University Hospital Leuven KU Leuven Leuven Belgium

Department of Pediatric Hematology and Oncology University Hospital Valencia Valencia Spain

Department of Pediatric Hematology Oncology and BMT University Hospital Muenster Münster Germany

Department of Pediatric Oncology University Hospital Le Fe Valencia Spain

Department of Pediatrics and AdolescentMedicine Li Ka Shing Faculty of Medicine The University of Hong Kong Queen Mary Hospital Hong Kong Special Administrative Region China

Division of Cellular and Molecular Pathology Department of Pathology University of Cambridge Cambridge UK; Central European Institute for Technology Masaryk University Brno Czech Republic

Division of Hemato Oncology Princess Máxima Center for Pediatric Oncology Utrecht Netherlands

Division of Hemato Oncology Princess Máxima Center for Pediatric Oncology Utrecht Netherlands; The Netherlands and Erasmus MC Sophia Children's Hospital Rotterdam Netherlands

Hannover Medical School Department of Pediatric Hematology and Oncology Hannover Germany

Institut d'Investigacions Biomèdiques August Pi i Sunyer Barcelona Spain

Institute of Pathology Hematopathology Section University of Schleswig Holstein Kiel Germany

Istituto di Ricerca Pediatrica Città della Speranza Padua Italy; Pediatric Hematology Oncology and Stem Cell Transplant Division Maternal and Child Health Department Padova University Hospital Padova Italy

Onco hematology Université Paris Cité and Necker Enfants Malades Hospital Assistance Publique Hôpitaux de Paris Paris France

Pediatric Hematology and Oncology Erasmus MC Sophia Children's Hospital Rotterdam the Netherlands

Pediatric Hematology and Oncology University Medical Centre Hamburg Eppendorf Hamburg Germany

Pediatric Hematology Oncology and Stem Cell Transplant Division Maternal and Child Health Department Padova University Hospital Padova Italy

Section of Pediatric Hematology Oncology and Stem Cell Transplantation Department of Pediatric and Adolescent Medicine RWTH Aachen University Hospital Aachen Germany

St Anna Children's Hospital Department of Paediatric Haematology and Oncology Medical University of Vienna Vienna Austria

The Newcastle upon Tyne Hospitals NHS Foundation Trust Newcastle upon Tyne UK; Wolfson Childhood Cancer Centre Translational and Clinical Research Institute Newcastle University Newcastle upon Tyne UK

Université Toulouse 3 Paul Sabatier Laboratoire d'Excellence Toulouse Cancer TOUCAN Équipe Labellisée La Ligue Contre Le Cancer Inserm Toulouse France

Wolfson Childhood Cancer Centre Translational and Clinical Research Institute Newcastle University Newcastle upon Tyne UK

Lancet Haematol. 2023 Jul;10(7):e490. doi: 10.1016/S2352-3026(23)00178-3. PubMed

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