Mature non-Hodgkin lymphomas (NHL) in the childhood, adolescent and young adult (CAYA) population are rare and exhibit unique clinical, immunophenotypic and genetic characteristics. Application of large-scale unbiased genomic and proteomic technologies such as gene expression profiling and next generation sequencing (NGS) have led to enhanced understanding of the genetic basis for many lymphomas in adults. However, studies to investigate the pathogenetic events in CAYA population are relatively sparse. Enhanced understanding of the pathobiologic mechanisms involved in non-Hodgkin lymphomas in this unique population will allow for improved recognition of these rare lymphomas. Elucidation of the pathobiologic differences between CAYA and adult lymphomas will also lead to the design of more rational and much needed, less toxic therapies for this population. In this review, we summarize recent insights gained from the proceedings of the recent 7th International CAYA NHL Symposium held in New York City, New York October 20-23, 2022.

Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center 417 East 68th New York City NY USA

Department of Pathology University of Cambridge Lab Block Level 3 Box 231 Addenbrookes Hospital Hills Road Cambridge CB20QQ UK; CEITEC Masaryk University Brno Czech Republic

Department of Pediatrics Memorial Sloan Kettering Cancer Center 1275 York Avenue Howard 14 New York City NY USA New York City NY USA

Institute of Human Genetics Ulm University and Ulm University Medical Center Albert Einstein Allee 11 D 89081 Ulm Germany

Pediatric Hematology Oncology and Stem Cell Transplant Division University Hospital of Padova via Giustiniani 3 35128 Padova Italy

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