Dual-chamber leadless pacing: Atrioventricular synchrony in preclinical models of normal or blocked atrioventricular conduction
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
37075958
DOI
10.1016/j.hrthm.2023.04.005
PII: S1547-5271(23)02104-5
Knihovny.cz E-zdroje
- Klíčová slova
- Atrioventricular synchrony, Aveir, Cardiac implantable electronic device, Conduction block, DDDR, Dual-chamber, Leadless pacemaker, Wireless communication, i2i,
- MeSH
- atrioventrikulární blokáda * terapie MeSH
- kardiostimulace umělá metody MeSH
- kardiostimulátor * MeSH
- lidé MeSH
- lipopolysacharidy MeSH
- ovce MeSH
- srdeční frekvence MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- lipopolysacharidy MeSH
BACKGROUND: Dual-chamber leadless pacemakers (LPs) require robust communication between distinct right atrial (RA) and right ventricular (RV) LPs to achieve atrioventricular (AV) synchrony. OBJECTIVE: The purpose of this preclinical study was to evaluate a novel, continuous implant-to-implant (i2i™) communication methodology for maintaining AV-synchronous, dual-chamber DDD(R) pacing by the 2 LPs. METHODS: RA and RV LPs were implanted and paired in 7 ovine subjects (4 with induced complete heart block). AV synchrony (% AV intervals <300 ms) and i2i communication success (% successful i2i transmissions between LPs) were evaluated acutely and chronically. During acute testing, 12-lead electrocardiographic and LP diagnostic data were collected from 5-minute recordings, in 4 postures and 2 rhythms (AP-VP and AS-VP, or AP-VS and AS-VS) per subject. Chronic i2i performance was evaluated through 23 weeks postimplant (final i2i evaluation period: week 16-23). RESULTS: Acute AV synchrony and i2i communication success across multiple postures and rhythms were median [interquartile range] 100.0% [100.0%-100.0%] and 99.9% [99.9%-99.9%], respectively. AV synchrony and i2i success rates did not differ across postures (P = .59, P = .11) or rhythms (P = 1, P = .82). During the final i2i evaluation period, the overall i2i success was 98.9% [98.1%-99.0%]. CONCLUSION: Successful AV-synchronous, dual-chamber DDD(R) leadless pacing using a novel, continuous, wireless communication modality was demonstrated across variations in posture and rhythm in a preclinical model.
Academic Medical Center Amsterdam The Netherlands
Hoag Memorial Hospital Newport Beach California
HonorHealth Research Institute Scottsdale Arizona
Huntington Hospital Pasadena California
Icahn School of Medicine at Mount Sinai New York New York; Na Homolce Hospital Prague Czech Republic
Libin Cardiovascular Institute Calgary Alberta Canada
MedStar Washington Hospital Center Washington DC
Na Homolce Hospital Prague Czech Republic
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