Impact of PFAS exposure on prevalence of immune-mediated diseases in adults in the Czech Republic
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
37116680
DOI
10.1016/j.envres.2023.115969
PII: S0013-9351(23)00761-2
Knihovny.cz E-resources
- Keywords
- Adult cohort, Allergy, Bayesian kernel machine regression, Eczema, Immune system, Perfluoroalkyl substances,
- MeSH
- Hypersensitivity * MeSH
- Dermatitis, Atopic * chemically induced epidemiology MeSH
- Bayes Theorem MeSH
- Child MeSH
- Eczema * MeSH
- Fluorocarbons * toxicity MeSH
- Alkanesulfonic Acids * toxicity MeSH
- Environmental Pollutants * toxicity MeSH
- Humans MeSH
- Longitudinal Studies MeSH
- Young Adult MeSH
- Prevalence MeSH
- Tandem Mass Spectrometry MeSH
- Check Tag
- Child MeSH
- Humans MeSH
- Young Adult MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Czech Republic epidemiology MeSH
- Names of Substances
- Fluorocarbons * MeSH
- Alkanesulfonic Acids * MeSH
- Environmental Pollutants * MeSH
- perfluorooctane sulfonic acid MeSH Browser
- perfluorooctanoic acid MeSH Browser
BACKGROUND: Per- and polyfluoroalkyl substances (PFASs) are emerging environmental contaminants with multiple hazardous properties including immunomodulation potency. Human exposure to PFASs has been associated with various immune-mediated diseases and outcomes. This study aimed to investigate the association between PFAS exposure and immune-mediated diseases such as allergies, eczemas, and autoimmune diseases in a population of adults in the Czech Republic. METHODS: This study included 309 adults from the Central European Longitudinal Study of Parents and Children: Young Adults (CELSPAC: YA). 12 PFASs were measured in participants' serum by HPLC-MS/MS, 3 PFASs were removed from the subsequent analyses due to low detection frequency. The associations of 9 PFASs with 9 immune-mediated diseases were assessed by logistic regression. Furthermore, Bayesian kernel machine regression (BKMR) was used to estimate the effect of the PFAS mixture on immune-mediated diseases. All analyses were adjusted for sex, age, BMI, smoking, education, and family history of immune-mediated diseases. In cases of a statistically significant interaction of PFASs and sex, stratified analyses were performed for men and women. RESULTS: Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) were negatively associated with both atopic eczema (OR per IQR increase 0.58 (95% CI 0.37-0.90) for PFOA and 0.56 (0.32-0.95) for PFOS) and contact dermatitis (0.37 (0.16-0.85) for PFOA and 0.33 (0.11-0.94) for PFOS). Perfluoroundecanoate (PFUnDA) was negatively associated with pollen, dust, and mite allergy (0.62 (0.43-0.89)). BKMR modelling showed a negative tendency in the overall effect of PFAS mixture on immune-health outcomes. Based on the stratified analysis, sex was suggested to be an effect modifier in the association of PFOS and atopic eczema. CONCLUSION: Our results contribute to the body of literature that observes the immunosuppressive effect of PFAS exposure during eczemas and allergies, both for PFASs individually and as a mixture.
Institute of Risk Assessment Sciences Utrecht University Yalelaan 2 Utrecht 3584CM Netherlands
RECETOX Faculty of Science Masaryk University Kotlarska 2 602 00 Brno Czech Republic
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