Recently deceased professor Luboslav Stárka was a world-renowned doctor who devoted his whole life to the study and therapeutic use of steroids, and was particularly interested in vitamin D. He knew from his own experience and from deep knowledge that this vitamin, one of the oldest steroids in development, must have a number of effects in addition to the undeniably positive effects on bones. He commissioned our task force to address the issues surrounding vitamin D, leading to years of studies with robust results made possible by the use of chromatography coupled with mass spectrometry (LC-MS), a so-called gold standard of measurement that is a cornerstone of recent scientific studies. This led to a whole series of scientific publications, the aim of which was to point out the possibility of using the abilities of vitamin D and thus also the gift that nature has given us.

Institute of Endocrinology Prague Czech Republic

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Tripathi A, Ansari M, Dandekar P, Jain R. Analytical methods for 25-hydroxyvitamin D: advantages and limitations of the existing assays. J Nutr Biochem. 2022;109:109123. doi: 10.1016/j.jnutbio.2022.109123. PubMed DOI

Bičíková M, Máčová L, Hill M. Vitamin D as a possible COVID-19 prevention strategy. Int J Mol Sci. 2022;23:10532. doi: 10.3390/ijms231810532. PubMed DOI PMC

Annweiler C, Schott AM, Berrut G, Chauviré V, Le Gall D, Inzitari M, Beauchet O. Vitamin D and ageing: neurological issues. Neuropsychobiology. 2010;62:139–150. doi: 10.1159/000318570. PubMed DOI

Erasmus R, Maepa S, Machingura I, Davids S, Raghubeer S, Matsha T. Vitamin D, Vitamin D-binding proteins, and VDR polymorphisms in individuals with Hyperglycaemia. Nutrients. 2022;30:14. doi: 10.3390/nu14153147. PubMed DOI PMC

Saporito MS, Brown ER, Hartpence KC, Wilcox HM, Vaught JL, Carswell S. Chronic 1,25-dihydroxyvitamin D3-mediated induction of nerve growth factor mRNA and protein in L929 fibroblasts and in adult rat brain. Brain Res. 1994;633:189–196. doi: 10.1016/0006-8993(94)91539-3. PubMed DOI

Brattico E, Bonetti L, Ferretti G, Vuust P, Matrone C. Putting cells in motion: advantages of endogenous boosting of BDNF production. Cells. 2021;10:183. doi: 10.3390/cells10010183. PubMed DOI PMC

Rana T, Behl T, Sehgal A, Srivastava P, Bungau S. Unfolding the Role of BDNF as a biomarker for treatment of depression. J Mol Neurosci. 2021;71:2008–2021. doi: 10.1007/s12031-020-01754-x. PubMed DOI

Goltz A, Janowitz D, Hannemann A, Nauck M, Hoffmann J, Seyfart T, Völzke H, Terock J, Grabe HJ. Association of brain-derived neurotrophic factor and vitamin D with depression and obesity: a population-based study. Neuropsychobiology. 2017;76:171–181. doi: 10.1159/000489864. PubMed DOI

Bičíková M, Dušková M, Vítků J, Kalvachová B, Řípová D, Mohr P, Stárka L. Vitamin D in anxiety and affective disorders. Physiol Res. 2015;64(Suppl 2):S101–103. doi: 10.33549/physiolres.933082. PubMed DOI

Casseb GAS, Kaster MP, Rodrigues ALS. Potential role of vitamin D for the management of depression and anxiety. CNS Drugs. 2019 Jul;33:619–637. doi: 10.1007/s40263-019-00640-4. PubMed DOI

Bicikova M, Macova L, Ostatnikova D, Hanzlikova L. Vitamin D in autistic children and healthy controls. Physiol Res. 2019;68:317–320. doi: 10.33549/physiolres.933902. PubMed DOI

Kim HJ, Ji M, Song J, Moon HW, Hur M, Yun YM. Clinical utility of measurement of vitamin D-binding protein and calculation of bioavailable vitamin D in assessment of vitamin D status. Ann Lab Med. 2017;37:34–38. doi: 10.3343/alm.2017.37.1.34. PubMed DOI PMC

Yurekli UF, Tunc Z. Eur Rev Med Pharmacol Sci. 2022. Nov 26, Correlation between Vitamin D, homocysteine and brain-derived neurotrophic factor levels in patients with ischemic stroke; pp. 8004–8010. PubMed

Al-Bayyari N, Hailat R, Subih H, Alkhalidy H, Eaton A. Vitamin D(3) reduces risk of cardiovascular and liver diseases by lowering homocysteine levels: double-blinded, randomised, placebo-controlled trial. Br J Nutr. 2021;125:139–146. doi: 10.1017/S0007114520001890. PubMed DOI

Recommendations abstracted from the American Geriatrics Society Consensus Statement on vitamin D for prevention of falls their consequences. J Am Geriatr Soc. 2014;62:147–152. doi: 10.1111/jgs.12631. PubMed DOI

Mikola T, Marx W, Lane MM, Hockey M, Loughman A, Rajapolvi S, Rocks T, O'Neil A, Mischoulon D, Valkonen-Korhonen M, Lehto SM, Ruusunen A. The effect of vitamin D supplementation on depressive symptoms in adults: A systematic review and meta-analysis of randomized controlled trials. Crit Rev Food Sci Nutr. 2022;11:1–18. doi: 10.1080/10408398.2022.2096560. PubMed DOI

Bicikova M, Macova L, Kolatorova L, Hill M, Novotny J, Jandova D, Starka L. Physiological changes after spa treatment - a focus on endocrinology. Physiol Res. 2018;67(Suppl 3):S525–S530. doi: 10.33549/physiolres.934016. PubMed DOI

Kafle S, Basnet AK, Karki K, Thapa Magar M, Shrestha S, Yadav RS. Association of vitamin D deficiency with pulmonary tuberculosis: a systematic review and meta-analysis. Cureus. 2021;13:e17883. doi: 10.7759/cureus.17883. PubMed DOI PMC

Ismailova A, White JH. Vitamin D, infections and immunity. Rev Endocr Metab Disord. 2022;23:265–277. doi: 10.1007/s11154-021-09679-5. PubMed DOI PMC

Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik SR, Ochoa MT, Schauber J, Wu K, Meinken C, Kamen DL, Wagner M, Bals R, Steinmeyer A, Zügel U, Gallo RL, Eisenberg D, Hewison M, Hollis BW, Adams JS, Bloom BR, Modlin RL. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science. 2006;311:1770–1773. doi: 10.1126/science.1123933. PubMed DOI

Papagni R, Pellegrino C, Di Gennaro F, Patti G, Ricciardi A, Novara R, Cotugno S, Musso M, Guido G, Ronga L, Stolfa S, Bavaro DF, Romanelli F, Totaro V, Lattanzio R, De Iaco G, Palmieri F, Saracino A, Gualano G. Impact of vitamin D in prophylaxis and treatment in tuberculosis patients. Int J Mol Sci. 2022;23 doi: 10.3390/ijms23073860. PubMed DOI PMC

Grant WB, Lahore H, McDonnell SL, Baggerly CA, French CB, Aliano JL, Bhattoa HP. Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths. Nutrients. 2020:12. doi: 10.3390/nu12040988. PubMed DOI PMC

Hosseini B, El Abd A, Ducharme FM. Effects of vitamin D supplementation on COVID-19 Related outcomes: a systematic review and meta-analysis. Nutrients. 2022;14:2134. doi: 10.3390/nu14102134. PubMed DOI PMC

Pal R, Banerjee M, Bhadada SK, Shetty AJ, Singh B, Vyas A. Vitamin D supplementation and clinical outcomes in COVID-19: a systematic review and meta-analysis. J Endocrinol Invest. 2022;45:53–68. doi: 10.1007/s40618-021-01614-4. PubMed DOI PMC

Hadizadeh F. Supplementation with vitamin D in the COVID-19 pandemic? Nutr Rev. 2021;79:200–208. doi: 10.1093/nutrit/nuaa081. PubMed DOI PMC

Villa JKD, Diaz MAN, Pizziolo VR, Martino HSD. Effect of vitamin K in bone metabolism and vascular calcification: A review of mechanisms of action and evidences. Crit Rev Food Sci Nutr. 2017;57:3959–3970. doi: 10.1080/10408398.2016.1211616. PubMed DOI

Palermo A, Tuccinardi D, D'Onofrio L, Watanabe M, Maggi D, Maurizi AR, Greto V, Buzzetti R, Napoli N, Pozzilli P, Manfrini S. Vitamin K and osteoporosis: Myth or reality? Metabolism. 2017;70:57–71. doi: 10.1016/j.metabol.2017.01.032. PubMed DOI

Ellis JL, Karl JP, Oliverio AM, Fu X, Soares JW, Wolfe BE, Hernandez CJ, Mason JB, Booth SL. Dietary vitamin K is remodeled by gut microbiota and influences community composition. Gut Microbes. 2021;13:1–16. doi: 10.1080/19490976.2021.1887721. PubMed DOI PMC

Huang SH, Fang ST, Chen YC. Molecular mechanism of vitamin K2 protection against amyloid-β-induced cytotoxicity. Biomolecules. 2021;11:423. doi: 10.3390/biom11030423. PubMed DOI PMC