WHAT IS THIS SUMMARY ABOUT?: Patient registries contain anonymous data from people who share the same medical condition. The MSBase registry contains information from over 80,000 people living with multiple sclerosis (MS) across 41 countries. Using information from the MSBase registry, the GLIMPSE (Generating Learnings In MultiPle SclErosis) study looked at real-life outcomes in 3475 people living with MS who were treated with cladribine tablets (Mavenclad®) compared with other oral treatments. WHAT WERE THE RESULTS?: Results showed that people treated with cladribine tablets stayed on treatment for longer than other treatments given by mouth. They also had fewer relapses (also called flare ups of symptoms) than people who received a different oral treatment for their MS. WHAT DO THE RESULTS MEAN?: The results provide evidence that, compared with other oral treatments for MS, cladribine tablets are an effective medicine for people living with MS.

Academic MS Center Zuyderland Department of Neurology Zuyderland Medical Center Sittard Geleen The Netherlands

American University of Beirut Medical Center Beirut Lebanon

Amiri Hospital Sharq Kuwait

Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino Avellino Italy

Bakirkoy Education and Research Hospital for Psychiatric and Neurological Diseases Istanbul Turkey

Center of Neuroimmunology Service of Neurology Hospital Clinic de Barcelona Barcelona Spain

Cliniques Universitaires Saint Luc UCLouvain Brussels Belgium

CORe Department of Medicine University of Melbourne Melbourne Australia

Department of Medical and Surgical Sciences and Advanced Technologies GF Ingrassia Catania Italy

Department of Neurology 19 Mayis University Samsun Turkey

Department of Neurology and Center of Clinical Neuroscience 1st Faculty of Medicine Charles University Prague and General University Hospital Prague Czech Republic

Department of Neurology Austin Health Melbourne Australia

Department of Neurology Galdakao Usansolo University Hospital Osakidetza Basque Health Service Biocruces Bizkaia Health Research Institute Galdakao Spain

Department of Neurology John Hunter Hospital Hunter New England Health Newcastle Australia

Department of Neuroscience Central Clinical School Monash University Melbourne Australia

Division of Neurology St Michael's Hospital University of Toronto Toronto Canada

Dokuz Eylul University Izmir Turkey

EMD Serono Research and Development Institute Inc Billerica MA USA an affiliate of Merck KGaA

Koc University School of Medicine and Koc University Research Center for Translational Medicine Istanbul Turkey

Liverpool Hospital Sydney Australia

MS Centre Department of Neurology Royal Melbourne Hospital Melbourne Australia

MSBase Foundation Melbourne Australia

Multiple Sclerosis Centre Neurology Departments of Head Spine and Neuromedicine Biomedicine and Clinical Research University Hospital Basel and University of Basel Basel Switzerland

Nemocnice Jihlava Jihlava Czech Republic

Neurology Institute Harley Street Medical Center Abu Dhabi United Arab Emirates

Neurology Unit Department of Medicine College of Medicine and Health Sciences and Sultan Qaboos University Hospital SQU Al Khodh Oman

Research Center for Clinical Neuroimmunology and Neuroscience University Hospital and University of Basel Switzerland

School for Mental Health and Neuroscience Maastricht University Maastricht The Netherlands

School of Medicine and Public Health University of Newcastle Newcastle Australia

University Hospital Ghent Ghent Belgium

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