Cancer-associated fibroblasts: Mediators of head and neck tumor microenvironment remodeling
Language English Country Netherlands Media print-electronic
Document type Journal Article, Review, Research Support, Non-U.S. Gov't
PubMed
37331641
DOI
10.1016/j.bbcan.2023.188940
PII: S0304-419X(23)00089-6
Knihovny.cz E-resources
- Keywords
- Cancer therapy, Cancer-associated fibroblasts, Head and neck cancer, Resistance to therapy, Tumor microenvironment,
- MeSH
- Squamous Cell Carcinoma of Head and Neck metabolism MeSH
- Cancer-Associated Fibroblasts * metabolism MeSH
- Humans MeSH
- Tumor Microenvironment MeSH
- Head and Neck Neoplasms * metabolism MeSH
- Signal Transduction MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
Cancer-associated fibroblasts (CAFs) are involved in critical aspects of head and neck squamous cell carcinoma (HNSCC) pathogenesis, such as the formation of a tumor-permissive extracellular matrix structure, angiogenesis, or immune and metabolic reprogramming of the tumor microenvironment (TME), with implications for metastasis and resistance to radiotherapy and chemotherapy. The pleiotropic effect of CAFs in TME is likely to reflect the heterogeneity and plasticity of their population, with context-dependent effects on carcinogenesis. The specific properties of CAFs provide many targetable molecules that could play an important role in the future therapy of HNSCC. In this review article, we will focus on the role of CAFs in the TME of HNSCC tumors. We will also discuss clinically relevant agents targeting CAFs, their signals, and signaling pathways, which are activated by CAFs in cancer cells, with the potential for repurposing for HNSCC therapy.
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