Wireless Monitoring of Gastrointestinal Transit Time, Intra-luminal pH, Pressure and Temperature in Experimental Pigs: A Pilot Study
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články
Grantová podpora
00179906
Ministerstvo Zdravotnictví Ceské Republiky
PubMed
37384804
DOI
10.14712/18059694.2023.9
PII: am_2023066010011
Knihovny.cz E-zdroje
- Klíčová slova
- acetylcholinesterase inhibitors, experimental pigs, gastrointestinal transit time, intra-luminal pH, oncology, pressure and temperature, toxicology, wireless capsule monitoring,
- MeSH
- dospělí MeSH
- gastrointestinální průchod * MeSH
- koncentrace vodíkových iontů MeSH
- lidé MeSH
- pilotní projekty MeSH
- prasata MeSH
- teplota MeSH
- tobolky MeSH
- zvířata MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- tobolky MeSH
BACKGROUND: There is no single gold standard for investigation of gastrointestinal motility function. Wireless motility monitoring involves a novel concept which provides a complex information on gastrointestinal function (gastrointestinal transit time, intra-luminal pH, pressure and temperature). Gastrointestinal motility functions of experimental pigs are very similar to those of humans. That is why porcine studies have already provided suitable experimental models for several preclinical projects. AIMS: The aim of our study was to adopt methods of non-invasive wireless monitoring of gastrointestinal functions in experimental pigs. METHODS: Five experimental adult female pigs were enrolled into the study. Wireless motility capsules were delivered into the porcine stomach endoscopically. Gastrointestinal transit and intra-luminal conditions were recorded for five days. RESULTS: Records of animals provided good (3 pigs) or very good quality files (2 pigs). 31150 variables were evaluated. Mean time of the presence of capsules in the stomach was 926 ± 295 min, transfer of a capsule from the stomach into the duodenum lasted 5-34 min. Mean small intestinal transit time was 251 ± 43 min. Food intake was associated with an increase of gastric luminal temperature and a decrease of intra-gastric pressure. The highest intra-luminal pH was present in the ileum. The highest temperature and the lowest intra-luminal pressure were found in the colon. All data displayed a substantial inter-individual variability. CONCLUSIONS: This pilot study has proven that a long-term function monitoring of the gastrointestinal tract by means of wireless motility capsules in experimental pigs is feasible. However, both ketamine-based induction of general anaesthesia as well as long-lasting general anaesthesia (> 6 hours) should be avoided to prevent retention of a capsule in the porcine stomach.
Biomedical Research Centre University Hospital Hradec Králové Czech Republic
Institute of Gastrointestinal Oncology Military University Hospital Praha Czech Republic
The Royal Marsden Hospital NHS Foundation Trust London United Kingdom
Citace poskytuje Crossref.org
