Low-dimensional compounds containing bioactive ligands. XXII. First crystal structure, cytotoxic activity and DNA and HSA binding of a zirconium(IV) complex with 8-hydroxyquinoline-2-carboxylic acid
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
Grant support
1/0126/23
Vedecká Grantová Agentúra MŠVVaŠ SR a SAV
APVV-18-0016
Agentúra na Podporu Výskumu a Vývoja
VVGS-PF-2022-2134
Univerzita P.J. Šafárika v Košiciach
VVGS-2022-2182
Univerzita P.J. Šafárika v Košiciach
VVGS-2022-2191
Univerzita P.J. Šafárika v Košiciach
LM2023051
Ministerstvo Školství, Mládeže a Tělovýchovy
ITMS2014+: 313011V455
European Regional Development Fund
PubMed
37466222
DOI
10.1107/s2053229623005971
PII: S2053229623005971
Knihovny.cz E-resources
- Keywords
- 8-hydroxyquinoline-2-carboxylic acid, DNA binding, HSA binding, ZrIV complex, bioactive ligand, crystal structure, cytotoxicity, low-dimensional,
- MeSH
- Dimethylformamide MeSH
- DNA chemistry MeSH
- Coordination Complexes * chemistry MeSH
- Crystallography, X-Ray MeSH
- Humans MeSH
- Serum Albumin, Human MeSH
- Ligands MeSH
- Oxyquinoline pharmacology MeSH
- Hydrogen Bonding MeSH
- Zirconium * pharmacology MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Dimethylformamide MeSH
- DNA MeSH
- Coordination Complexes * MeSH
- Serum Albumin, Human MeSH
- Ligands MeSH
- Oxyquinoline MeSH
- Zirconium * MeSH
A new zirconium(IV) complex, diaquabis(8-hydroxyquinoline-2-carboxylato-κ3N,O2,O8)zirconium(IV) dimethylformamide disolvate, [Zr(C10H5NO3)2(H2O)2]·2C3H7NO or [Zr(QCa)2(H2O)2]·2DMF (1) (HQCaH is 8-hydroxyquinoline-2-carboxylic acid and DMF is dimethylformamide), was prepared and characterized by elemental analysis, IR spectroscopy and single-crystal X-ray structure analysis. Complex 1 is a mononuclear complex in which the ZrIV atoms sit on the twofold axis and they are octacoordinated by two N and six O atoms of two tridentate anionic QCa2- ligands, and two aqua ligands. Outside the coordination sphere are two DMF molecules bound to the complex unit by hydrogen bonds. The structure and stability of complex 1 in dimethyl sulfoxide were verified by NMR spectroscopy. The cytotoxic properties of 1 and HQCaH were studied in vitro against eight cancer cell lines, and their selectivity was tested on the BJ-5ta noncancerous cell line. Both the complex and HQCaH exhibited low activity, with IC50 > 200 µM. DNA and human serum albumin (HSA) binding studies showed that 1 binds to calf thymus (CT) DNA via intercalation and is able to bind to the tryptophan binding site of HSA (Trp-214).
Department of Pharmacology P J Šafárik University in Košice Trieda SNP 1 Košice SK 040 11 Slovakia
Institute of Chemistry P J Šafárik University in Košice Moyzesova 11 Košice SK 041 54 Slovakia
Institute of Physics of the Czech Academy of Science Na Slovance 2 Prague CZ 182 21 Czech Republic
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