Recommendations for wider adoption of clinical pharmacy in Central and Eastern Europe in order to optimise pharmacotherapy and improve patient outcomes
Status PubMed-not-MEDLINE Language English Country Switzerland Media electronic-ecollection
Document type Journal Article
PubMed
37601045
PubMed Central
PMC10433912
DOI
10.3389/fphar.2023.1244151
PII: 1244151
Knihovny.cz E-resources
- Keywords
- clinical pharmacy, cost-effective treatment, drug safety, drug utilization, health policy, medication adherence, medication errors, polypharmacy,
- Publication type
- Journal Article MeSH
Clinical pharmacy as an area of practice, education and research started developing around the 1960s when pharmacists across the globe gradually identified the need to focus more on ensuring the appropriate use of medicines to improve patient outcomes rather than being engaged in manufacturing and supply. Since that time numerous studies have shown the positive impact of clinical pharmacy services (CPS). The need for wider adoption of CPS worldwide becomes urgent, as the global population ages, and the prevalence of polypharmacy as well as shortage of healthcare professionals is rising. At the same time, there is great pressure to provide both high-quality and cost-effective health services. All these challenges urgently require the adoption of a new paradigm of healthcare system architecture. One of the most appropriate answers to these challenges is to increase the utilization of the potential of highly educated and skilled professionals widely available in these countries, i.e., pharmacists, who are well positioned to prevent and manage drug-related problems together with ensuring safe and effective use of medications with further care relating to medication adherence. Unfortunately, CPS are still underdeveloped and underutilized in some parts of Europe, namely, in most of the Central and Eastern European (CEE) countries. This paper reviews current situation of CPS development in CEE countries and the prospects for the future of CPS in that region.
Children's Clinical University Hospital Riga Latvia
College of Pharmacy QU Health Qatar University Doha Qatar
Department of Clinical Pharmacology Wroclaw Medical University Wroclaw Poland
Department of Clinical Pharmacy Ormoz Psychiatric Hospital Ormoz Slovenia
Department of Family Medicine Medical University of Lodz Lodz Poland
Department of Hospital Pharmacy Bajcsy Zsilinszky Hospital Budapest Hungary
Department of Pharmacology Faculty of Medicine Maribor University of Maribor Maribor Slovenia
European Directorate for the Quality of Medicines and Healthcare Council of Europe Strasbourg France
European Society of Clinical Pharmacy Leiden Netherlands
Faculty of Medicine University of Latvia Riga Latvia
Independent Expert Thessaloniki Greece
Institute of Pharmacy Faculty of Medicine University of Tartu Tartu Estonia
Medicines Optimisation Innovation Centre Antrim Hospital Antrim United Kingdom
Pharmacy Department National Institute of Oncology Budapest Hungary
Regional Specialist Hospital in Wroclaw Wroclaw Poland
School of Pharmacy and Pharmaceutical Sciences Ulster University Coleraine Northern Ireland
See more in PubMed
AAHP (2023). Arbeitsgemeinschaft österreichischer krankenhausapotheker. Available at: https://www.aahp.at/ (Accessed January 5, 2023).
Anderson S. V., Schumock G. T. (2009). Evaluation and justification of clinical pharmacy services. Expert Rev. Pharmacoecon Outcomes Res. 9, 539–545. 10.1586/erp.09.57 PubMed DOI
Aristotle University of Thessaloniki (2018). Bulletin of studies - school of pharmacy. Available at: https://www.pharm.auth.gr/wp-content/uploads/sites/83/2019/01/Odigos-Spoudon-English-2018_2019_2_-_1_.pdf (Accessed January 5, 2023).
Bond C. A., Raehl C. L., Patry R. (2004). Evidence-based core clinical pharmacy services in United States hospitals in 2020: Services and staffing. Pharmacotherapy 24, 427–440. 10.1592/phco.24.5.427.33358 PubMed DOI
Brajković A., Bićanić L. A., Strgačić M., Orehovački H., Ramalho-de-Oliveira D., Mucalo I. (2022a). The impact of pharmacist-led medication management services on the quality of life and adverse drug reaction occurrence. Pharmacy 10, 102. 10.3390/pharmacy10050102 PubMed DOI PMC
Brajković A., Bosnar L., Nascimento M. M. G., Prkačin I., Balenović A., Ramalho de Oliveira D., et al. (2022b). Healthcare utilisation and clinical outcomes in older cardiovascular patients receiving comprehensive medication management services: A nonrandomised clinical study. Int. J. Environ. Res. Public Health 19, 2781. 10.3390/ijerph19052781 PubMed DOI PMC
Brink A. J., Messina A. P., Feldman C., Richards G. A., Becker P. J., Goff D. A., et al. (2016). Antimicrobial stewardship across 47 South African hospitals: An implementation study. Lancet Infect. Dis. 16, 1017–1025. 10.1016/S1473-3099(16)30012-3 PubMed DOI
Bryla A., Urbańczyk K., Stachowiak A., Burkacka M., Steczko M., Wiela-Hojeńska A. (2020). Clinical pharmacy – At what stage are we in Poland? Farm Pol. 76, 175–182. 10.32383/farmpol/121064 DOI
Bundes-Zielsteuerungskommission (2017). Österreichischer strukturplan gesundheit. Available at: https://www.sozialministerium.at/Themen/Gesundheit/Gesundheitssystem/Gesundheitssystem-und-Qualitaetssicherung/Planung-und-spezielle-Versorgungsbereiche/Der-%C3%96sterreichische-Strukturplan-Gesundheit-%E2%80%93-%C3%96SG-2017.html (Accessed March 28, 2023).
Byrne S., Dalton K. (2017). Role of the pharmacist in reducing healthcare costs: Current insights. Integr. Pharm. Res. Pract. 6, 37–46. 10.2147/IPRP.S108047 PubMed DOI PMC
Carter B. L. (2016). Evolution of clinical pharmacy in the USA and future directions for patient care. Drugs Aging 33, 169–177. 10.1007/s40266-016-0349-2 PubMed DOI PMC
Chevalier B., Neville H. L., Thompson K., Nodwell L., Macneil M. (2016). Health care professionals' opinions and expectations of clinical pharmacy services on a surgical ward. Serv. a Surg. Ward 69, 439–448. 10.4212/cjhp.v69i6.1606 PubMed DOI PMC
Clinical (2023). Clinical pharmacy course in Estonia. Available at: https://sisu.ut.ee/clinicalpharmacy/avaleht?lang=et (Accessed March 28, 2023).
Clinical Pharmacy Section (2023). Clinical pharmacy section of Slovak pharmaceutical society. Available at: https://sekciaklinfarm.sk/ (Accessed February 3, 2023).
Comenius University in Bratislava (2022a). Description of clinical pharmacy program in Slovakia. Available at: https://ais2.uniba.sk/repovsk/repository/default/ais/vsk/Farmaceuticka_fakulta/farmacia/studijny_program/klinicka_farmacia_(III._st._denna_forma)_(dKFC)/UK_2022/Opis_studijneho_programu_(EN).pdf (Accessed January 5, 2023).
Comenius University in Bratislava (2022b). Description of pharmacy study program in Slovakia. Available at: https://ais2.uniba.sk/repovsk/repository/default/ais/vsk/Farmaceuticka_fakulta/farmacia/studijny_program/farmacia_(I.II._st._denna_forma)_(FA)/UK_2022/Opis_studijneho_programu_(EN).pdf (Accessed January 5, 2023).
Committee of Ministers Resolution CM/Res(2020)3 on the implementation of pharmaceutical care for the benefit of patients and health services. Available at: https://go.edqm.eu/ResPhCare20203 (Accessed March 22, 2023).
Curtin D., Gallagher P. F., O’Mahony D. (2019). Explicit criteria as clinical tools to minimize inappropriate medication use and its consequences. Ther. Adv. Drug Saf. 10, 2042098619829431. 10.1177/2042098619829431 PubMed DOI PMC
Czech Republic Parliament (2011). Law on health care services and conditions for their provision. Available at: https://www.zakonyprolidi.cz/cs/2011-372 (Accessed March 25, 2023).
Dreischulte T., van den Bemt B., Steurbaut S. (2022). European society of clinical pharmacy definition of the term clinical pharmacy and its relationship to pharmaceutical care: A position paper. Int. J. Clin. Pharm. 44, 837–842. 10.1007/s11096-022-01422-7 PubMed DOI PMC
European Society of Clinical Pharmacy (2023a). European society of clinical pharmacy. Available at: https://escpweb.org/ (Accessed March 28, 2023).
European Society of Clinical Pharmacy (2023b). Oath to society. Available at: https://escpweb.org/about-us/oath-to-society-2/ (Accessed March 28, 2023).
European Society of Hospital Pharmacy (2023). European standards for hospital pharmacy (Bulgarian version). Available at: https://www.eahp.eu/hp-practice/hospital-pharmacy/european-statements-hospital-pharmacy (Accessed March 28, 2023).
Faculty of Pharmacy in Hradec Kralove (2023). University Centre of clinical pharmacy. Available at: https://www.faf.cuni.cz/UCCP/ (Accessed February 3, 2023).
Falamić S., Lucijanić M., Hadžiabdić M. O., Marušić S., Bačić Vrca V. (2018). Pharmacist’s interventions improve time in therapeutic range of elderly rural patients on warfarin therapy: A randomized trial. Int. J. Clin. Pharm. 40, 1078–1085. 10.1007/s11096-018-0691-z PubMed DOI
Falamić S., Lucijanić M., Ortner-Hadžiabdić M., Marušić S., Bačić-Vrca V. (2019). Pharmacists’ influence on adverse reactions to warfarin: A randomised controlled trial in elderly rural patients. Int. J. Clin. Pharm. 41, 1166–1173. 10.1007/s11096-019-00894-4 PubMed DOI
Falamić S., Lucijanić M., Ortner-Hadžiabdić M., Marušić S., Bačić-Vrca V. (2021). Pharmacists’ interventions improve health-related quality of life of rural older person on warfarin: A randomized controlled trial. Sci. Rep. 11, 21897–7. 10.1038/s41598-021-01394-0 PubMed DOI PMC
Fernandes O., Toombs K., Pereira T., Lyder C., Bjelajac Mejia A., Shalansky S., et al. (2015). Canadian consensus on clinical pharmacy key performance indicators: Quick reference guide. Available at: https://www.cshp.ca/sites/default/files/files/publications/Official Publications/CPKPI/CSPH-Can-Concensus-cpKPI-QuickReferenceGuide_June_2017.pdf.
Fialová D., Brkić J., Laffon B., Reissigová J., Grešáková S., Dogan S., et al. (2019). Applicability of EU(7)-PIM criteria in cross-national studies in European countries. Ther. Adv. Drug Saf. 10, 2042098619854014–2042098619854022. 10.1177/2042098619854014 PubMed DOI PMC
Galvin M., Jago-Byrne M. C., Fitzsimons M., Grimes T. (2013). Clinical pharmacist’s contribution to medication reconciliation on admission to hospital in Ireland. Int. J. Clin. Pharm. 35, 14–21. 10.1007/s11096-012-9696-1 PubMed DOI
Gillespie U., Alassaad A., Henrohn D., Garmo H., Hammarlund-Udenaes M., Toss H., et al. (2009). A comprehensive pharmacist intervention to reduce morbidity in patients 80 years or older: A randomized controlled trial. Arch. Intern Med. 169, 894–900. 10.1001/archinternmed.2009.71 PubMed DOI
Good pharmacy practice (2021). Official gazette of RS. Available at: https://www.farmkom.rs/pdf/stranice/Vodič DAP.pdf (Accessed January 5, 2023).
Greece Pharmacy Profession (2023). Greece pharmacy profession act. Available at: http://www.pefni.gr/sites/default/files/Files/ΠΔ 108-1993.pdf (Accessed January 5, 2023).
Greek hospital legislation Greek hospital legislation (2023). Available at: https://www.ispatras.gr/νομοθεσία/ιατρική-νομοθεσία/ν-4999-φεκ-225-7-12-2022-τα΄-δευτεροβάθμια-περίθαλψη/ [Accessed January 5, 2023].
Gregorová J., Bačová J., Langmaierová K., Murínová I., Netíková I., Kozáková Š., et al. (2014). Concept of clinical- pharmaceutical care in the Czech republic. Available at: https://www.coskf.cz/media/files/koncepce.pdf (Accessed March 27, 2023).
Gregorová J., Langmaierová K. (2022). Clinical pharmaceutical care and health care system in the Czech republic. Available at: https://www.ipvz.cz/seznam-souboru/7176-klinicka-farmacie.pdf (Accessed March 27, 2023).
Grimes T. C., Deasy E., Allen A., O’Byrne J., Delaney T., Barragry J., et al. (2014). Collaborative pharmaceutical care in an Irish hospital: Uncontrolled before-after study. BMJ Qual. Saf. 23, 574–583. 10.1136/bmjqs-2013-002188 PubMed DOI PMC
Hahn M., Ritter C., Roll S. C. (2018). Validation of pharmacist–physician collaboration in psychiatry: ‘the eichberger-model. Int. J. Clin. Pharm. 40, 1001–1004. 10.1007/s11096-018-0664-2 PubMed DOI
Hanlon J. T., Schmader K. E. (2013). The medication appropriateness Index at 20: Where it started, where it has been, and where it may Be going. Drugs Aging 30, 893–900. 10.1007/s40266-013-0118-4 PubMed DOI PMC
Hellström L. M., Bondesson Å., Höglund P., Midlöv P., Holmdahl L., Rickhag E., et al. (2011). Impact of the Lund Integrated Medicines Management (LIMM) model on medication appropriateness and drug-related hospital revisits. Eur. J. Clin. Pharmacol. 67, 741–752. 10.1007/s00228-010-0982-3 PubMed DOI
Institute for Postgraduate Education in Healthcare (Czech Republic) (2022). Educational program Clinical Pharmacy specialized training 2020. Available at: https://www.ipvz.cz/seznam-souboru/5329-klinicka-farmacie-specializovany-vycvik-2020.pdf (Accessed March 25, 2023).
Institute of Statistics Republic of Srpska (2023a). Institute of statistics republic of Srpska. Available at: https://www.rzs.rs.ba/ (Accessed March 29, 2023).
Institute of Statistics Republic of Srpska (2023b). Institute of statistics republic of Srpska. Available at: https://www.rzs.rs.ba/static/uploads/saopstenja/nacionalni_racuni/bdp_godisnji/proizvodni_pristup/2021/BDP_Proizvodni_Pristup_2021.pdf (Accessed March 29, 2023).
Jankyova S., Rubintova D., Foltanova T. (2020). The analysis of the use of potentially inappropriate medications in elderly in the Slovak Republic. Int. J. Clin. Pharm. 42, 100–109. 10.1007/s11096-019-00944-x PubMed DOI
Javor E., Allouch A., Osvaldić Galic J., Skelin M. (2021). The economic impact of a clinical pharmacist’s involvement in the hospital medicines policy in a rural area. Int. J. Clin. Pract. 75, 1–8. 10.1111/ijcp.14859 PubMed DOI
Kardas P., Lewek P., Matyjaszczyk M. (2013). Determinants of patient adherence: A review of systematic reviews. Front. Pharmacol. 4, 91. 10.3389/fphar.2013.00091 PubMed DOI PMC
Kardas P., Urbański F., Lichwierowicz A., Chudzyńska E., Kardas G., Czech M. (2021). Prevalence and age structure of polypharmacy in Poland: Results of the analysis of the national real-world database of 38 million citizens. Front. Pharmacol. 12, 1–9. 10.3389/fphar.2021.655364 PubMed DOI PMC
Karl-Franzens-Universität Graz (2018). Curriculum für das Masterstudium Pharmazie an der Karl-Franzens-Universität Graz. Available at: https://pharmazie.uni-graz.at/de/studieren-und-lehren/studienangebot/masterstudium-pharmazeutische-wissenschaften/ (Accessed March 28, 2023).
Klinische Pharmazie (2012). Klinische Pharmazie – medikationsanalyse. Available at: https://www.postgraduatecenter.at/weiterbildungsprogramme/gesundheit-naturwissenschaften/klinische-pharmazie-medikationsanalyse/ (Accessed January 5, 2023).
Lea M., Mowé M., Molden E., Kvernrød K., Skovlund E., Mathiesen L. (2020). Effect of medicines management versus standard care on readmissions in multimorbid patients: A randomised controlled trial. BMJ Open 10, e041558. 10.1136/bmjopen-2020-041558 PubMed DOI PMC
Lee H., Ryu K., Sohn Y., Kim J., Suh G. Y., Kim E. Y. (2019). Impact on patient outcomes of pharmacist participation in multidisciplinary critical care teams: A systematic review and meta-analysis. Crit. Care Med. 47, 1243–1250. 10.1097/CCM.0000000000003830 PubMed DOI
Leopold-Franzens-Universität Innsbruck (2021). Curriculum für das Masterstudium Pharmazie an der Fakultät für Chemie und Pharmazie der Universität Innsbruck. Available at: https://www.uibk.ac.at/studium/angebot/ma-pharmazie/index.html.de (Accessed March 28, 2023).
Mair A., Fernandez-Llimos F., Alonso A., Harrison C., Hurding S., Kempen T., et al. (2017). Polypharmacy management by 2030: A patient safety challenge. 2nd edition. Coimbra: SIMPATHY Consortium.
Mair A., Fernandez-Llimos F., SIMPATHY Consortium. (2017). Polypharmacy management programmes: The SIMPATHY Project. Eur. J. Hosp. Pharm. 24, 5–6. 10.1136/ejhpharm-2016-001044 PubMed DOI PMC
Mair A., Wilson M., Dreischulte T. (2019). The polypharmacy programme in Scotland: Realistic prescribing. Prescriber 30, 10–16. 10.1002/psb.1779 DOI
Marinović I., Bačić Vrca V., Samardžić I., Marušić S., Grgurević I., Papić I., et al. (2021). Impact of an integrated medication reconciliation model led by a hospital clinical pharmacist on the reduction of post-discharge unintentional discrepancies. J. Clin. Pharm. Ther. 46, 1326–1333. 10.1111/jcpt.13431 PubMed DOI
Marinović I., Marušić S., Mucalo I., Mesarić J., Vrca V. B. (2016). Clinical pharmacist-led program on medication reconciliation implementation at hospital admission: Experience of a single University hospital in Croatia. Croat. Med. J. 57, 572–581. 10.3325/cmj.2016.57.572 PubMed DOI PMC
Master in Clinical Pharmacy (2023). Master in clinical pharmacy. Available at: https://www.pharm.uoa.gr/spoydes/metaptychiakes_spoydes/pms_stin_kliniki_farmakeytiki/ (Accessed January 5, 2023).
McCarthy C., Thomas Bateman M. (2022). Impact of pharmacist-led chronic disease management in a federally qualified health center. JACCP J. Am. Coll. Clin. Pharm. 5, 1263–1277. 10.1002/jac5.1720 DOI
Mccusker E., Scott M., Boyce T., MacIntyre J., Friel A. (2013). Northern Ireland clinical pharmacy standards. Available at: https://www.health-ni.gov.uk/sites/default/files/publications/dhssps/northern-ireland-clinical-pharmacy-standards-2013.pdf.
McMullin S. T., Hennenfent J. A., Ritchie D. J., Huey W. Y., Lonergan T. P., Schaiff R. A., et al. (1999). A prospective, randomized trial to assess the cost impact of pharmacist-initiated interventions. Arch. Intern Med. 159, 2306–2309. 10.1001/archinte.159.19.2306 PubMed DOI
Medikationsanalyse Basiskurs (2023). Medikationsanalyse Basiskurs. Available at: https://www.apothekerkammer.at/fortbildungen-apotheker?esraSoftIdva=71253 (Accessed January 5, 2023).
Midão L., Giardini A., Menditto E., Kardas P., Costa E. (2018). Polypharmacy prevalence among older adults based on the survey of health, ageing and retirement in Europe. Arch. Gerontol. Geriatr. 78, 213–220. 10.1016/j.archger.2018.06.018 PubMed DOI
Minimal standard for specialty study program in clinical pharmacy (2010). Journal of the Ministry of health of the Slovak republic. Available at: https://www.health.gov.sk/?Minimalne-standardy-pre-specializacne-studijne-programy-minimalne-standardy-pre-certifikacne-studijne-programy-a-minimalne-standardy-pre-studijne-programy-sustavneo-vzdelavania (Accessed January 5, 2023).
Ministry of Health of Czech Republic (2012). Decree on minimal personal security of health care services. Available at: https://www.zakonyprolidi.cz/cs/2012-99 (Accessed March 27, 2023).
Morrison V. L., Holmes E. A. F., Parveen S., Plumpton C. O., Clyne W., De Geest S., et al. (2015). Predictors of self-reported adherence to antihypertensive medicines: A multinational, cross-sectional survey. Value Health 18, 206–216. 10.1016/j.jval.2014.12.013 PubMed DOI
Moura L., Steurbaut S., Salvesen Blix H., Addison B., Rabus S., Mota-Filipe H., et al. (2022). A cross-sectional survey to map clinical pharmacy education and practice in Europe. Int. J. Clin. Pharm. 44, 118–126. 10.1007/s11096-021-01321-3 PubMed DOI
Mucalo I., Brajković A., Strgačić M., Ramalho-De-oliveira D., Ribarić E., Bobinac A. (2022). Budget impact analysis of pharmacist-led medication management in cardiovascular and type 2 diabetic patients. Healthc. Switz. 10, 1–18. 10.3390/healthcare10040722 PubMed DOI PMC
Müller D. (2012). ZZ630 - ein Meilenstein für die Klinische Pharmazie in Österreich. Vienna: ÖAZ.
OECD (2021). Health at a Glance 2021, 274. Available at: https://www.oecd-ilibrary.org/social-issues-migration-health/health-at-a-glance-2021_ae3016b9-en.
OECED (2023a). Gross domestic product (GDP) (indicator). 10.1787/dc2f7aec-en DOI
OECED (2023b). Health spending (indicator). 10.1787/8643de7e-en DOI
OECED (2023c). Population (indicator). 10.1787/d434f82b-en DOI
OHPB (2022). Professional organization of the hospital pharmacists in Bulgaria. Available at: https://ohpb.eu/.
Österreichische Apothekerkammer (2020). Österreichische apothekerkammer: Apotheke in zahlen. Available at: https://www.apothekerkammer.at/infothek/zahlen-daten-fakten/apotheke-in-zahlen-2020 (Accessed January 5, 2023).
Paracelsus Medizinische Privatuniversität (2020). Übersicht curriculum bachelor und masterstudium pharmazie.
PEFNI (1988). Panhellenic association of hospital pharmacists. Available at: http://www.pefni.gr/.
Perez A., Touchette D. R., Doloresco F., Suda K. J., Turner S., Jalundhwala Y., et al. (2008). Economic evaluations of clinical pharmacy services: 2001-2005. Pharmacotherapy 28, 285e–323e. 10.1592/phco.29.1.128 PubMed DOI
PFS (2016). Panhellenic pharmaceutical association. Available at: https://pfs.gr/.
Polish Ministry of Health (2020). Raport opieka farmaceutyczna. Kompleksowa analiza procesu wdrożenia. Available at: https://www.gov.pl/web/zdrowie/opieka-farmaceutyczna---raport (Accessed March 28, 2023).
Polish Ministry of Health (2022). Rozwiązania w zakresie farmacji klinicznej oraz działalności farmaceutów w podmiotach leczniczych. 1–94. Available at: https://www.gov.pl/web/zdrowie/raport-2022-rozwiazania-w-zakresie-farmacji-klinicznej-oraz-dzialalnosci-farmaceutow-w-podmiotach-leczniczych.
Polish Society of Clinical Pharmacy (2021). Medicines reconciliation (Koncyliacja lekowa). Available at: https://ptfk.pl/wp-content/uploads/2021/11/PTFK_standard_koncyliacji_lekowej_wydanie-I.pdf.
Reardon D. P., Atay J. K., Ashley S. W., Churchill W. W., Berliner N., Connors J. M. (2015). Implementation of a hemostatic and antithrombotic stewardship program. J. Thromb. Thrombolysis 40, 379–382. 10.1007/s11239-015-1189-3 PubMed DOI
RIS - Apothekengesetz - Bundesrecht konsolidiert (2022). Fassung vom 08.12.2022. Available at: https://www.ris.bka.gv.at/GeltendeFassung.wxe?Abfrage=Bundesnormen&Gesetzesnummer=10010169 (Accessed January 5, 2023).
RIS (2022). Ris - apothekenbetriebsordnung 2005 - Bundesrecht konsolidiert, fassung vom 08.12.2022. Available at: https://www.ris.bka.gv.at/GeltendeFassung.wxe?Abfrage=Bundesnormen&Gesetzesnummer=20003947 (Accessed January 5, 2023).
Rule book on the nomenclature of health (2023a). Rule book on the nomenclature of health services at the primary level of health care. Official Gazette of RS. Available at: https://www.paragraf.rs/propisi/pravilnik-o-nomenklaturi-zdravstvenih-usluga-na-primarnom-nivou-zdravstvene-zastite.html (Accessed January 5, 2023).
Rule book on the nomenclature of health (2023b). Rule book on the nomenclature of health services at the second and tertiary levels of health care. Official Gazette of RS. Available at: https://www.paragraf.rs/propisi/pravilnik-o-nomenklaturi-zdravstvenih-usluga-sekundarnom-tercijarnom-nivou-zdravstvene-zastite-jun-2019.html (Accessed January 5, 2023).
Rules on the provision of pharmacy services by hospital pharmacies (2022). Official journal republic of Slovenia. Available at: http://pisrs.si/Pis.web/pregledPredpisa?id=PRAV13164 (Accessed December 19, 2022).
Rychlickova J., Saloun J., Gregorova J. (2016). Evaluation of clinical pharmacists’ interventions in the Czech republic. Pharmacother. J. Hum. Pharmacol. Drug Ther. 35, 766–773. 10.1002/phar.1777 PubMed DOI
Santschi V., Chiolero A., Colosimo A. L., Platt R. W., Taffé P., Burnier M., et al. (2014). Improving blood pressure control through pharmacist interventions: A meta-analysis of randomized controlled trials. J. Am. Heart Assoc. 3, e000718. 10.1161/JAHA.113.000718 PubMed DOI PMC
Schulz M., Griese-Mammen N., Anker S. D., Koehler F., Ihle P., Ruckes C., et al. (2019). Pharmacy-based interdisciplinary intervention for patients with chronic heart failure: Results of the PHARM-CHF randomized controlled trial. Eur. J. Heart Fail 21, 1012–1021. 10.1002/ejhf.1503 PubMed DOI
Schumock G. T., Butler M. G., Meek P. D., Vermeulen L. C., Arondekar B. V., Bauman J. L., et al. (2003). Evidence of the economic benefit of clinical pharmacy services: 1996–2000. Pharmacotherapy 23, 113–132. 10.1592/phco.23.1.113.31910 PubMed DOI
Schumock G. T., Meek P. D., Ploetz P. A., Vermeulen L. C. (1996). Economic evaluations of clinical pharmacy services-1988-1995. The publications committee of the American College of clinical pharmacy. Pharmacotherapy 16, 1188–1208. 10.1002/j.1875-9114.1996.tb03049.x PubMed DOI
Scott M. G., Scullin C., Hogg A., Fleming G. F., McElnay J. C. (2015). Integrated medicines management to medicines optimisation in northern Ireland (2000-2014): A review. Eur. J. Hosp. Pharm. 22, 222–228. 10.1136/ejhpharm-2014-000512 DOI
Scottish Government Polypharmacy Model of Care Group (2018). Polypharmacy guidance, realistic prescribing. 3rd Edition. Scottish: Scottish Government. Available at: https://www.therapeutics.scot.nhs.uk/wp-content/uploads/2018/04/Polypharmacy-Guidance-2018.pdf (Accessed November 20, 2022).
Scullin C., Scott M. G., Hogg A., McElnay J. C. (2007). An innovative approach to integrated medicines management. J. Eval. Clin. Pract. 13, 781–788. 10.1111/j.1365-2753.2006.00753.x PubMed DOI
Simoens S., Spinewine A., Foulon V., Paulus D. (2011). Review of the cost-effectiveness of interventions to improve seamless care focusing on medication. Int. J. Clin. Pharm. 33, 909–917. 10.1007/s11096-011-9563-5 PubMed DOI
Slovenian Ministry of Health (2022). Evaluation procedure at the Ministry of health. Available at: https://www.gov.si/assets/ministrstva/MZ/DOKUMENTI/ZBIRKE/Zdravstveni-svet/Zapisnik-5.-seje-Zdravstvenega-sveta-14.-12.-2022.pdf (Accessed March 27, 2023).
Slovenian Pharmacy Act (Pharmacy Practice Act) (2016). Official journal republic of Slovenia. Available at: http://www.pisrs.si/Pis.web/pregledPredpisa?id=ZAKO7375 (Accessed December 19, 2022).
Spehar A. M., Campbell R. R., Cherrie C., Palacios P., Scott D., Baker J. L., et al. (2005). Advances in patient safety: From research to implementation in, eds. Henriksen K., Battles J. B., Marks E. S., Lewin D. I. Seamless care: Safe patient transitions from hospital to home ResearchGate; (Rockville (MD)). PubMed
Stewart D., Gibson-Smith K., MacLure K., Mair A., Alonso A., Codina C., et al. (2017). A modified Delphi study to determine the level of consensus across the European Union on the structures, processes and desired outcomes of the management of polypharmacy in older people. PLoS One 12, e0188348. 10.1371/journal.pone.0188348 PubMed DOI PMC
Study programme on clinical (1960). Study programme on clinical pharmacy specialization in Serbia. Available at: http://pharmacy.bg.ac.rs/files/Programi/Specijalističke studije/Zdravstvene specijalizacije/Klinicka farmacija.pdf (Accessed January 5, 2023).
Stuhec M., Bratović N., Mrhar A. (2019). Impact of clinical pharmacist’s interventions on pharmacotherapy management in elderly patients on polypharmacy with mental health problems including quality of life: A prospective non-randomized study. Sci. Rep. 9, 16856–16858. 10.1038/s41598-019-53057-w PubMed DOI PMC
Stuhec M. (2021). Clinical pharmacist consultant in primary care settings in Slovenia focused on elderly patients on polypharmacy: Successful national program from development to reimbursement. Int. J. Clin. Pharm. 43, 1722–1727. 10.1007/s11096-021-01306-2 PubMed DOI
Stuhec M., Tement V. (2021). Positive evidence for clinical pharmacist interventions during interdisciplinary rounding at a psychiatric hospital. Sci. Rep. 11, 13641–13648. 10.1038/s41598-021-92909-2 PubMed DOI PMC
Švec P., Kuželová M. (2012). 35 years of education in clinical pharmacology at the faculty of pharmacy in Comenius university. Acta Fac. Pharm. Univ. Comen 59, 67–75. 10.2478/V10219-012-0008-6 DOI
Touchette D. R., Doloresco F., Suda K. J., Perez A., Turner S., Jalundhwala Y., et al. (2014). Economic evaluations of clinical pharmacy services: 2006-2010. Pharmacotherapy 34, 771–793. 10.1002/phar.1414 PubMed DOI
University of Belgrade (2023). Pharmacy study programme at faculty of pharmacy university of belgrade. Available at: http://www.pharmacy.bg.ac.rs/files/English/Integrated Academic Study/Course timetable per years and semesters.pdf (Accessed January 5, 2023).
Urbańczyk K., Wnęk P., Roleder T., Witkiewicz W., McCague P., Scott M., et al. (2022). Optimized and cost-effective pharmacotherapy of vascular surgery patients: Evaluation of clinical pharmacy service. Italian J. Vasc. Endovascular Surg. 29, 74–79. 10.23736/s1824-4777.22.01534-0 DOI
VAAOE (2023). Vaaoe – Verband angestellter apotheker Österreich. Available at: https://vaaoe.at/ (Accessed January 5, 2023).
Vlček J., Fialová D., Malý J., Pávek P., Halačová M., Doseděl M., et al. (2016). Concept of Clinical Pharmacy field-history of the field, definitions, pregraduate and postgraduate education, activities of clinical pharmacists. Czech and Slovac Pharmacy Suppl, 1–16. Available at: https://www.prolekare.cz/casopisy/ceska-slovenska-farmacie/2016/dokumenty/supplementum-koncepce-oboru-klinicka-farmacie-37 (Accessed March 27, 2023).
WHO (2018). Expenditure database. Available at: https://data.worldbank.org/indicator/SH.XPD.CHEX.PP.CD [Accessed March 29, 2023].
WHO (2015). Global action plan on antimicrobial resistance. Available at: http://www.who.int/drugresistance/global_action_plan/en/ (Accessed January 21, 2018).
WHO (2022). Health systems in action: Bosnia and Herzegovina. Available at: https://apps.who.int/iris/rest/bitstreams/1463801/retrieve (Accessed March 28, 2023).
WHO (2017). The third WHO global patient safety challenge: Medication without harm. Available at: https://www.who.int/patientsafety/medication-safety/en/ (Accessed August 23, 2020). PubMed
Wien U. (2019). Curriculum für das Masterstudium Pharmazie. Available at: https://ssc-lebenswissenschaften.univie.ac.at/pharmazie/masterstudium/curriculum/ (Accessed March 28, 2023).
Yuliandani Y., Alfian S. D., Puspitasari I. M. (2022). Patient satisfaction with clinical pharmacy services and the affecting factors: A literature review. Pharmacia 69, 227–236. 10.3897/pharmacia.69.e80261 DOI
Scope, content and quality of clinical pharmacy practice guidelines: a systematic review