Bifidobacteria as a strictly anaerobic gram-positive bacteria, is widely distributed in the intestine, vagina and oral cavity, and is one of the first gut flora to colonize the early stages of life. Intestinal flora is closely related to health, and dysbiosis of intestinal flora, especially Bifidobacteria, has been found in a variety of diseases. Numerous studies have shown that in addition to maintaining intestinal homeostasis, Bifidobacteria may be involved in diseases covering all parts of the body, including the nervous system, respiratory system, genitourinary system and so on. This review collects evidence for the variation of Bifidobacteria in typical diseases among various systems, provides mild and effective therapeutic options for those diseases that are difficult to cure, and moves Bifidobacteria from basic research to further clinical applications.

Rongcheng Municipal Hospital of Traditional Chinese Medicine Rongcheng Shandong China

Shandong 1st Medical University and Shandong Academy of Medical Sciences Shandong Academy of Occupational Health and Occupational Medicine Jinan Shandong China

Shandong Academy of Occupational Health and Occupational Medicine Shandong 1st Medical University and Shandong Academy of Medical Sciences Jinan Shandong China

Shandong University of Traditional Chinese Medicine Doctoral candidate Class of 2022 Jinan Shandong China

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