Standardized pharmacological response tests are important and established diagnostic tools in the field of neurology. However, regarding therapeutic responses to intravenous immunoglobulins (IVIg) in CIDP, neither a definition of therapeutic response has been established, nor a response test has been suggested so far. Here we suggest a practical clinical approach which is supported by current literature in the field. An established standardized IVIg response test could avoid prolonged therapy without benefit for the patient and ensure a timely therapy switch or treatment escalation if required. This approach would also be advantageous due to the global scarcity of plasma derivatives as a human resource and could be the foundation to be adjusted and improved by subsequent studies.

Brain and Mind Center University of Sydney Sydney New South Wales Australia

Center for Translational Neuro and Behavioral Sciences University of Duisburg Essen Essen Germany

Department of Neurology Essen University Hospital University Duisburg Essen Essen Germany

Department of Neurology Friedrich Baur Institute Ludwig Maximilians University Munich Munich Germany

Department of Neurology Medical Faculty Heinrich Heine University Düsseldorf Düsseldorf Germany

Department of Neurology Palacky University Olomouc Olomouc Czechia

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