Tract-wise microstructural analysis informs on current and future disability in early multiple sclerosis
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu časopisecké články
Grantová podpora
NTC03706118
Roche
NU 22-04-00193
Czech Ministry of Health
Project Cooperation LF1 - reasearch area Neuroscience
Czech Ministry of Education
RVO VFN 64165
Charles University and General University Hospital in Prague
PubMed
37819462
PubMed Central
PMC10827809
DOI
10.1007/s00415-023-12023-3
PII: 10.1007/s00415-023-12023-3
Knihovny.cz E-zdroje
- Klíčová slova
- Demyelinating diseases, Magnetic resonance imaging, Multiple sclerosis, Relaxometry, White matter,
- MeSH
- bílá hmota * diagnostické zobrazování patologie MeSH
- lidé MeSH
- magnetická rezonanční tomografie metody MeSH
- mozek diagnostické zobrazování patologie MeSH
- průřezové studie MeSH
- roztroušená skleróza * diagnostické zobrazování patologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
OBJECTIVES: Microstructural characterization of patients with multiple sclerosis (MS) has been shown to correlate better with disability compared to conventional radiological biomarkers. Quantitative MRI provides effective means to characterize microstructural brain tissue changes both in lesions and normal-appearing brain tissue. However, the impact of the location of microstructural alterations in terms of neuronal pathways has not been thoroughly explored so far. Here, we study the extent and the location of tissue changes probed using quantitative MRI along white matter (WM) tracts extracted from a connectivity atlas. METHODS: We quantified voxel-wise T1 tissue alterations compared to normative values in a cohort of 99 MS patients. For each WM tract, we extracted metrics reflecting tissue alterations both in lesions and normal-appearing WM and correlated these with cross-sectional disability and disability evolution after 2 years. RESULTS: In early MS patients, T1 alterations in normal-appearing WM correlated better with disability evolution compared to cross-sectional disability. Further, the presence of lesions in supratentorial tracts was more strongly associated with cross-sectional disability, while microstructural alterations in infratentorial pathways yielded higher correlations with disability evolution. In progressive patients, all major WM pathways contributed similarly to explaining disability, and correlations with disability evolution were generally poor. CONCLUSIONS: We showed that microstructural changes evaluated in specific WM pathways contribute to explaining future disability in early MS, hence highlighting the potential of tract-wise analyses in monitoring disease progression. Further, the proposed technique allows to estimate WM tract-specific microstructural characteristics in clinically compatible acquisition times, without the need for advanced diffusion imaging.
Advanced Clinical Imaging Technology Siemens Healthineers International AG Lausanne Switzerland
Department of Radiology Lausanne University Hospital and University of Lausanne Lausanne Switzerland
LTS5 École Polytechnique Fédérale de Lausanne Lausanne Switzerland
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